人體內有多少化合物？ 可能是人類曆史上最大的奇跡！
金豬寶
問題：人體內有多少化合物？（Question: how many chemicals are in the human body?）
A. 我的假定答案是：100,000，最低限度(My putative Answer is: 100,000,the minimum)
看我的分析(See my analysis).
B. 有些顆粒無法排出體外 (Some Particles Cannot Get Out of the Body).
DDT、666， 等等雖然早已被禁用，但仍可在人體中找到。(DDT, 666, etc. can be found in human bodies even though they were banned a long time ago). (動物的肉裏一定有惰性的小顆粒)。
C. 石棉、玻璃纖維,薄膜等惰性材料可致癌(Inert materials such as asbestos, fiberglass, and films can cause cancer).
人體細胞和細胞間空間可能充滿了小顆粒（包括人造化合物和人造的元素）。忽略潛在的生化幹擾，僅它們占據的細胞空間和細胞之間的空間就足以毀掉人的健康。 我記得許多惰性材料，包括石棉、玻璃纖維和惰性薄膜，都可能導致人類或動物模型患癌症。人們對它們致癌的作用機製知之甚少。在現代世界，慢性疾病的一個更好的術語是“化合物綜合症”，而疾病症狀可出現在心髒、肝髒、腎髒、肺、大腦或任何其他器官上。(Ignoring potential chemical interference, just the space occupation by them may be enough to ruin human health. It is possible that the human cells and inter-cellular spaces are filled with fanny particles including those including man-made elements. I recall that many inert materials including asbestos, fiberglass, and films can cause cancer in humans or animals models. Their action mechanisms in causing cancer are poorly understood. So, a better term of chronic diseases in this modern world is Toxic Chemical Syndrome, while disease signs would be on the heart, liver, kidneys, lungs, brain, or any other organs.）
（醫學文化是不見棺材不掉淚： the pathophysiological consequences of the amount of micro-plastics retained in the human body are yet unclear，BUT… Studies on toxicity due to the polymeric composition of micro-plastics in marine, freshwater, and terrestrial organisms reported various toxic effects but the most frequently mentioned were oxidative stress-related endpoints [B]. There is a lack of toxicity data for humans in vivo at the moment. However, several studies have looked at the effect of pristine micro-plastics in human cells in culture [49]. In these studies, as in animal models, the main detected endpoint was oxidative stress with reactive oxygen species (ROS) generation [50–54]. Other toxic effects regarded lipid metabolism, microbiota, neurotoxicity, inflammatory and immunological responses, cytotoxic effects, disruption of mitochondrial membrane potential, inhibition of plasma membrane ATP-binding cassette (ABC) transporter activity [47,52,55]. (I must take it without any hesitation that micro-plastics must cause diseases.）
這Gambino 2022文章又晚了10年：我們已吃了大量大量的塑料小顆粒，細細查看所有含塑料的並和食物接觸的東西。
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附件：
我的分析如下（My Analysis is as follows）:
1. One crystal clean bottle of waster contain 24,500 chemicals. This is very suppressing indeed because humans always thought that bottled water is the purest [A].
2. Virtually every chemical that has been made by humans has been found in wild animals and human bodies including newborns’.
3. There is a massive number of micro-particles, which could come from plastics or recycled plastics. Those particles could be created by mechanical force and weather effects.
4. Biological materials such as proteins, DNA, fats, carbohydrates, fibers, etc. can be broken down by thermal processes. They can become all kinds of products with different sizes and different molecular weights or elements.
5. Free radicals generated by various heavy metals in human bodies can break down any of the biological materials become smaller pieces.
6. All biological materials and degraded biological materials (chemically-degraded products, thermalized products, etc) must be able to absorb other small molecules by very weak non-covalent bonds to form more complex chemical entities.
7. Some chemicals may become crystallized when their concentrations are too higher due to accumulation.
8. Due to technical limitations, it is impossible to detect those chemical entities at very low concentration. So, prediction must be made by considering the possible combination of elements. Various stones can cause great pain.
9. To make a prediction, I would have to consider the number of elements available.
There are about 90 naturally occurring elements known on Earth. Using technology, scientists have been able to create nearly 30 additional elements that do not occur in nature. Today, chemistry recognizes 118 elements—some of which were created an atom at a time.
Now, we see the real exciting part: we will have a single element (which can still have different valence values), 2-elements combinations, 3-elements combination, 4-elements combinations etc, which will be something like infinity for practical purpose. However, most of combinations cannot happen (even considering the absorption factor). Assuming only a tiny fraction of the theoretic limit can exist, that can be safely be more than 100,000. This is an extremely conservative prediction.
It is possible that the human cells and inter-cellular spaces are filled with fanny particles including those including man-made elements.
Some chemicals may disrupt biological processes by interacting with the biological processes.
“Now, micro-plastics are ubiquitous particles and have been found both in aquatic [18,19] and terrestrial [20,21] ecosystems becoming a global environmental issue. They have been studied and well documented in marine waters [22], surface water bodies [23,24], waste water [25,26] and groundwater [27].”
Ingestion through contaminated foods represents one of the main pathways through
which micro-plastics enter the human body [38]. They were traced in many foods, such as fish products [39,40], edible mollusks [30], fruit and vegetables [41], table salt [42,43] and industrial and packaged food [44,45] as a result of environmental or process contamination. The ingested micro-plastics are mostly excreted (up to 90%) [39] and were detected in humans’ feces [46] but the pathophysiological consequences of the amount of micro-plastics retained in the human body are yet unclear.
Studies on toxicity due to the polymeric composition of micro-plastics in marine, freshwater, and terrestrial organisms reported various toxic effects but the most frequently mentioned were oxidative stress-related endpoints [B]. There is a lack of toxicity data for humans in vivo at the moment. However, several studies have looked at the effect of pristine micro-plastics in human cells in culture [49]. In these studies, as in animal models, the main detected endpoint was oxidative stress with reactive oxygen species (ROS) generation [50–54]. Other toxic effects regarded lipid metabolism, microbiota, neurotoxicity, inflammatory and immunological responses, cytotoxic effects, disruption of mitochondrial membrane potential, inhibition of plasma membrane ATP-binding cassette (ABC) transporter activity [47,52,55]. (I must take it without any hesitation that micro-plastics must cause various diseases.)
References:
A. Wagner Ma, Schlüsener MP, Ternes TA,Oehlmann J. Identification of Putative Steroid Receptor Antagonists in Bottled Water: Combining Bioassays and High-Resolution Mass Spectrometry August 28, 2013
https://doi.org/10.1371/journal.pone.0072472
B. Gambino I, Bagordo F, Grassi T. et. al. Occurrence of Microplastics in Tap and Bottled Water: Current Knowledge. Int. J. Environ. Res. Public Health 2022, 19, 5283. https://doi.org/10.3390/ijerph19095283
(Thousands of researches articles would be found.)
