【Molecules 2022, 27(17)】感染者或者打疫苗的人，納豆激酶可對抗SPIKE

都知道SPIKE有毒。不贅述了。如何消滅SPIKE遺留？好像IMV可以。還有一些別的物質可以去除SPIKE。

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic and has inflicted enormous damage on the lives of the people and economy of many countries worldwide. However, therapeutic agents against SARS-CoV-2 remain unclear. SARS-CoV-2 has a spike protein (S protein), and cleavage of the S protein is essential for viral entry. Nattokinase is produced by Bacillus subtilis var. natto and is beneficial to human health. In this study, we examined the effect of nattokinase on the S protein of SARS-CoV-2. When cell lysates transfected with S protein were incubated with nattokinase, the S protein was degraded in a dose- and time-dependent manner. Immunofluorescence analysis showed that S protein on the cell surface was degraded when nattokinase was added to the culture medium. Thus, our findings suggest that nattokinase exhibits potential for the inhibition of SARS-CoV-2 infection via S protein degradation.

由嚴重急性呼吸係統綜合症冠狀病毒 2 (SARS-CoV-2) 引起的 2019 年冠狀病毒病 (COVID-19) 已成為一種流行病，對全球許多國家的人民生活和經濟造成了巨大損害。 然而，針對 SARS-CoV-2 的治療劑仍不清楚。 SARS-CoV-2 具有刺突蛋白（S 蛋白），S 蛋白的切割對於病毒進入至關重要。 納豆激酶由枯草芽孢杆菌變種產生。 納豆對人體健康有益。 在這項研究中，我們檢查了納豆激酶對 SARS-CoV-2 的 S 蛋白的影響。 當用 S 蛋白轉染的細胞裂解物與納豆激酶一起孵育時，S 蛋白以劑量和時間依賴性方式降解。 免疫熒光分析表明，在培養基中加入納豆激酶後，細胞表麵的 S 蛋白被降解。 因此，我們的研究結果表明，納豆激酶具有通過 S 蛋白降解抑製 SARS-CoV-2 感染的潛力。

 

嚐嚐納豆。