沒法做人的實驗。動物實驗顯示腸道問題先於神經症狀出現之前。

“G93A mice have dysbiosis (imbalanced gut bacterial profile), disrupted tight junction structure, and increased intestinal permeability (leaky gut). These changes occur in young G93A mice before ALS symptom onset, suggesting that impaired gut-neuromuscular crosstalk may actively contribute to ALS progression and pathogenesis.”  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344195/?