01 引言 搞了十餘年藥物研發,感覺最深刻的是關鍵要有一個靈活的頭腦和豐富的有機合成知識,靈活的頭腦是天生的,豐富的有機合成知識是靠大量的閱讀和高手交流得到的。二者缺一不可,隻有有機合成知識而沒有靈活的頭腦把知識靈活的應用,充其量隻是有機合成匠人,成不了高手,也就沒有創造性。隻有靈活的頭腦而沒有知識,隻能做無米之炊。一個有機合成高手在頭腦中掌握的有機化學反應最少應為300個以上,並能靈活的加以運用,熟悉其中的原理(機理),爛熟於胸,就像國學大師爛熟四書五經一樣,看到了一個分子結構,稍加思索,其合成路線應該馬上在腦中浮現出來。 02 基本功的訓練 每個行業都有自己的基本功,有機合成的基本功就是對有機化學反應的理解掌握與靈活運用。那麽對有機化學反應的理解掌握應從那方麵入手?你在大學裏學到的有機合成知識,隻是入門的東西,遠遠達不到高手的水平,學了四年化學,基本上不理解化學。遇到問題還是束手無策,不知從何處下手。這不是你的問題,而是大學教育體製的問題,在大學階段應該打下堅實的基本功,然後才能專,而我們的大學在這方麵還做的遠遠不夠。下麵我推薦幾本有機合成方麵的書籍希望能夠達到上述的目的: 有機化學反應的理解掌握方麵的書籍: 1. March’s advanced organic chemistry. 2. Carey, F.A.; Sundberg, R.J.: Advanced organic chemistry.化學 3. Michael B. Smith: Organic synthesis. 4. Richard C. Larock: Comprehensive organic transformation. 5. 黃憲:新編有機合成化學 6. 李長軒:有機合成設計 前三本書是從機理方麵來討論有機合成的,4、5兩本書是從官能團轉變的角度討論有機合成的,第6本書是討論有機合成路線設計的。以上幾本書應該隨時放在自己的身邊,作為案頭書。認真精讀,達到記憶理解,把反應分類記憶理解,這時你可能感覺很枯燥乏味,不要緊,經過一段時間的合成研究再回過頭來閱讀,就會感覺耳目一新,有新的理解。掌握了這幾本書,可以說您已經打下了一定的有機合成基本功,這時你應該最少掌握300個反應了,但並不意味者你已經成為了有機合成高手,接下來你需要做的是將學到的有機合成知識能夠靈活運用,熟練的理解化學反應在什麽情況下應用。 下麵推薦的幾本雜誌,主要是關於如何運用有機化學反應的。 1. Organic synthesis (80vol.) 2. Organic Process Research & Development. 這是美國化學會出版的一本有機合成雜誌,主要講述一些化工產品的工藝研究,書中的反應均用在大規模的製備上,對產業化的研究很有幫助,這些反應具有很強的實用性,對理解化學反應的應用很有幫助。 經過以上知識的訓練,你已經具備成為有機合成高手的潛力了,接下來需要做的就是大量的實踐研究了,相信經過自己的努力和多年的實踐,多次的失敗,吃的苦中苦,你就成為有機合成高手了。 03 合成路線的選擇 合成路線的設計與選擇是有機合成中很重要的一個方麵,它反映了一個有機合成人員的基本功和知識的豐富性與靈活的頭腦。一般情況下,合成路線的選擇與設計代表了一個人的合成水平和素質。合理的合成路線能夠很快的得到目標化合物,而笨拙的合成路線雖然也能夠最終得到目標化合物,但是付出的代價卻是時間的浪費和合成成本的提高,因此合成路線的選擇與設計是一個很關鍵的問題。 合成路線的選擇與設計應該以得到目標化合物的目的為原則,即如果得到的目標化合物是以工業生產為目的,則選擇的合成路線應該以最低的合成成本為依據,一般情況下,簡短的合成路線應該反應總收率較高,因而合成成本最低,而長的合成路線總收率較低,合成成本較高,但是,在有些情況下,較長的合成路線由於每步反應都有較高的收率,且所用的試劑較便宜,因而合成成本反而較低,而較短的合成路線由於每步反應收率較低,所用試劑價格較高,合成成本反而較高。所以,如果以工業生產為目的,則合成路線的選擇與設計應該以計算出的和實際結果得到的合成成本最低為原則。 如果得到的目標化合物是以發表論文為目的,則合成路線的選擇與設計則有不同的原則。設計的路線應盡量具有創造性,具有新的思想,所用的試劑應該是新穎的,反應條件是創新的,這時考慮的主要問題不是合成成本的問題而合成中的創造性問題。 如果合成的是係列化合物,則設計合成路線時,應該共同的步驟越長越好,每個化合物隻是在最後的合成步驟中不同,則這樣的合成路線是較合理的和高效率的,可以在很短的時間內得到大量目標化合物。 每個目標化合物的合成路線一般有多步反應,為了避免雜質放大的問題,最好的解決辦法是將合成路線一分為二,轉化為兩個中間體,最後將兩個中間體通過一步反應組裝起來得到目標化合物。盡量避免連續反應隻在最後一步得到產物。 04 有機反應的實質 有機合成的任務是運用已知的或可能的化學反應來形成C-C鍵或C-雜鍵,從而將兩個或多個分子或離子連接起來。 有機化學反應類型可分為三種:極性反應,協同反應,自由基反應,其中協同反應與自由基反應又稱為非極性反應。非極性反應可以采用‘一鍋法’進行,而極性反應則需分步進行。因為極性反應的條件比較苛刻(無水、惰性氣體保護、強酸或強堿),而非極性反應的條件比較溫和。極性反應占80%,非極性反應占20%。極性反應的實質就是分子中負電性的原子與正電性的原子的結合。所謂負電性與正電性都是指廣義而言的,原子的負電性可以是負電荷,也可以是孤電子對;原子的正電性可以是正電荷也可以是空軌道。 負電性與正電性的密度越大,反應活性越高,但是高密度的負電性原子通常與高密度的正電性原子結合,低密度的負電性原子與低密度的正電性原子結合。如果分子中同時存在兩種相反電荷的原子則產生環合反應,如果分子中存在兩種相同電荷的原子,此時與另一分子中相反電荷的原子結合時就容易產生副反應,通常密度較高電荷的原子先進行反應。 因此,在記憶化學反應時,隻需分清分子中那個原子是正電性的,那個原子是負電性的就可以了。不必去記憶什麽人名反應來浪費記憶力,也不必對親核、親電反應的類型太在意。 所以,學習化學反應時,主要的任務就是了解各種正電性的基團和負電性的基團。這些正電性的基團和負電性的基團稱之為合成子。下麵舉例簡單說明: 舉例說明: ![](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAiMAAAFaCAYAAADM710lAAAgAElEQVR4nOy9d3hV553v+1ll9y1tdSQkJNFBIJpBFFMNLrEn7vE4iRPH8ZTcm2fmzDnz3HPmZu4kmUkmeU4yeWZOJuWZ3PHNnDiJMyl27AC2A7apxiCZLjACJAGiCfW9tesq94+td7G0EQEXEOX9PI8eNrustfbab/m+v/Yqtm3bSCQSiUQikYwS6mhfgEQikUgkktsbKUYkEolEIpGMKlKMSCQSiUQiGVWkGJFIJBKJRDKqSDEikUgkEolkVJFiRCKRSCQSyagixYhEIpFIJJJRRYoRieQGJp1OO4+TyeSIjwFs28YwDOf/hmFgmua1v0CJRCL5CFBk0TOJ5MYmnU6jqiq6rmNZFqp6cQ0Rj8dRFIVAIOA8l0ql0DQNXddH43IlEonkfSMtIxLJDYxpmmQyGUdYuC0gpmkSDAbx+XzO+9PpNLquo+u6tIxIJJKbBrl0kkhuYDKZDKFQCIBoNEpHRwcDAwOYpkkqlaK2tpbCwkIKCgowTRPDMPB6vQAMDAxQWFg4mpcvkUgkV4V000gkNzi2bbNnzx727t2LZVkYhkFvby+maZKfn09VVRXTpk2jqqqKUCiEpmlAVsh4PJ5RvnqJRCK5MlKMSCQ3OPv27eP111+np6eHGTNmUF1djWmaWJZFT08P7e3tRKNRFixYwJo1awgGg6RSqWHuG4lEIrmRkW4aieQGpqenh+3bt5NIJFi+fDnTpk1j3LhxjsUjGo2yfft2fve737Fr1y5mzpzJhAkTZLyIRCK5qZBi5CbHBhQssC/GItvKxdeVHLuXrQx/v62ARTaSOfsxK+cMKiOZzpQRnpN89PT19dHa2kpdXR33338/lmWRTCbxeDzE43F8Ph+rVq0iFotx5MgR+vr6AGQmjUQiuamQ2TQ3MTYQT8cBC0wLDAvbSJO20iRsg7RpgAkYYMfjYGawsMiYaYxoFMys9DCAeHpIhJgGVioBtomZytaysMgeRvxdlCu5wkXyfnFbMAzDQHhNbdump6eHtrY2TNOkurqaTCZDOp0mGAySyWTw+/3ouo7P52PJkiX4/X4aGxvp6upCVVVpHZHc8GQyGVKpFJY1fCwR/SCdTjuPM5kMmUzGeY+7Bs8HxX3eDxKxcLlrtyzrkudHA5GN50bEnf0hLMu65HPXGrl8uqmx0DxDejKTxooNopYUoilgo6JpQMoERUPx+UEDGwtbVfAEs3UpbLICQ9WzFhBFVVE1BbDAtpz3iG4l1etHiwg2BVCUi/Ymy7IcQTJx4kQKCgrYt28f7e3tKIpCf3+/I0q6urqYPHkyoVCI1tZWTpw4QUlJyRUHHIlktPF4PNi2TSaTQdM0FEVxRLmu605mGGT7ilswuF/7oLhr9oj+l0qlnGtzvz4SIi5LFBkU9X3cfXk0EfcslUoN+z5i3DFN07lW27axbRtVVZ2/64kUI7cENug6aiQCQCqTIppKURTOB02DVAZ82cZn2AY+RQfbxorFSITCaLl9eqhxisaokBUhwwXJ6Kv+Ww33ACYGhWAwiGVZDA4O0tPTw6uvvsrAwACQHSzz8vJIp9OEw2E0TSMYDDq/m2EY0l0jueFxCwxVVYeJjFgs5kyitm0PE+/XCkVR0HX9qibjVCqFoigoiuKIKcuynOduBIQ4Et8nV4C5/y8WQbZtX/frlyPVTY6u6PT0dlPkywfdw0BvL2vf3MCmt9/meMtRim0v/9df/BdmzJtD65kTePIDTJ4wkfaDB/nNi79jzaeeZtykGgIq2PZQLIhlgaqi5KSFXowrGcK2hp6Q9pKPAnfnVxTFERsHDhygtLSUu+66i/z8fDKZDGPGjCGTydDZ2UlBQQHt7e20tbUxb948J4DV7/eP4reRSK6McCV6PJ4RJ79wODzi54TLJhgMfqjzu10pQkC8H4uLYRgEg8Fh134jptTniji36AAuESrCzXQ9xJ9AipGbHAWbcDAEqoe2ffv5zr//Gy1nT1M5fjzjx08kGDd5c9Mm/vcvfk6wKI/Hnvpjmpqa+Pdv/TMvvrSWKUtXMaa6hrzQkK6wh7TIpdLDdU4cF47kw5Fb3l0Mapqm4fP5mDRpEuXl5Zw8eZJkMsnq1auBrL88nU7T0NBAKpXinXfeoaenhylTphCJRIhGo+Tl5Y3Kd5JIrpbclblhGI5lQVVVRyyI/4v3ejyej2TCd1tbkskkmqY5xx0cHHQKDl4O8bplWZimOSxOS9O06+7qyCWdTg8TeuL63PfSMAwMw3C2nBCvX2/kkvYmJ22k8fo8GL09PPfcc6xbt45Jkybxta99je//6/f47r/9kEWLlnD06FFOnjwJqoJpZEglBgkEfCTiSXSfKy5EGWoSlwnmkg3mo0UEu41kFvV4POi6zsKFCzlz5gwvvPAC586dAyCRSBAOh2lpaeGXv/wlR48eZerUqYwZMwYAv9//gQLyJJLrSa4QsW0br9eLx+NxhIGIexCr9Y+yXbuP5fP5hgmcq3VxingRj8eD3+/H7/fj8XhuiABWtxARQk+4kwQiNud6WkFGQlpGbmIUwD/UYX7xi1+wbds2PvWpT/EXX/oSeXkFJDMGZn+KFfffR83kiWzcupFYLMbqpcvx/MVfcP5CH4qm4h1qBZYNmgKqrg+JEfsyxhEr+5rkQ+PE5VzGP1taWsr8+fPp7u7m4MGD/OAHP3CEhq7rZDIZLMti1qxZrF69mry8PMdMfDUrO4lkNBGWQWENcQuAeDyO3+/HsqxhQaEi00O4Mj8MmqY5sVXi+D09PRiGQSAQuKrCge5rTiQSmKaJ1+v9SAJsPyzuccUtQizLIhaLEY/HCQaD5OXlDQtkzf3s9UCKkZucVCaF17bZv3cPPT09LF26lKJIAXHA69EJFupgwtixY6mvryelWxhmGp9Xp6enJzsQMJQmnEgRCXpArFZMyzGF3BihWLceI3V4saJSVRVFUcjLy+Ppp5/mzJkzfO973+PIkSNUVFSwb98+7rzzTh555BEmTJhAKBQinU5jGAYej0cKEckNj6Iol8QtmKZJR0cHp06dYvPmzRQWFjJx4kSmT59ORUUFHo/nI5voFUXBNE3HbdHX18e+fftIJpNUVVVRX1//Bz8vhMzAwAC7d++mqamJTCbD7NmzmTdvHuXl5R/JdX5QhMiD4WPNuXPnOHXqFPv372f8+PHU1dUxduzYS953PbltxIjbV3a5my1SId07pCaTSY4fP053dzeFhYVUVFQ4O6XmmvGi0Sg+n8/pKKIkt9u0+IfOPxLust6GYTidx7ZtfD4Nv8dD17kzHDp0iFAoxJRpdQymkqRVDa/Hg5UBVQNN97Jg4WJs3SaViNLdfQGfL+sGEDYOXfdgpE101QJNzWbi5HAxXkSYIEfXtHcrkLsSETVCkskkfr8fr9dLIpFgzJgxfOMb33D806ItiQHdsqxhKzLbtp10w9y0YcGVfMMjZeRcLtJenEvg9lfnBhyKNny7Z/u4gx1Fiqs7kyM30FDETtwomRpXwv39MpnMJYHVImtMfJ90Os2xY8dYu3YtGzduJB6P09/fT2lpKffeey/33nuvI7w1TSMWizlBrolEAk3TnPb/h+KmRJyE6F/i/N3d3bz++utYlsUXvvAFTp48SXFxMYZhEBnKVnRbHHVd57333mPDhg1s3LiRgwcPoqoq06dPZ8aMGXzyk5+kpKSEsrIyp62L+AxVVZ0x3f3nvjdX+p3d7xFWGXfQr7sdCWvS2bNnefXVV1m/fj2KonDPPfcwadKkK/6W15rbZiRwD5LuDi4GcMh2BPHYNE2am5vZsWMH69atY9u2bYwZM4bHHnuMBx98kOnTpxMOh53CMF6v12n4vb29+Hw+Z+D9MMFAQogkk0l8Pp+TQpYdnEziyTjd3d34fD5nA7WqyZPQgAt9UUpUP6GABy3gIWOmsTWbYCBIXiiMkUrT1dXFQBT8eaB7VXRUsA3ABtPMpgwjE3mvFe4JXExGwvysaRqJRMLxQYv3dHd3OxN9cXHxsMF8cHBwSKj6nJgT8Tn3hHa1k1lu23XHt6iqSiKRIBDI1qxx14FwZyWICUX4poV4ut2FCFyaZpm74h/tAMgPi8fjIZFIABAIBJx27A4W7e3txePxkEql+O1vf8tPf/pTwuEwjz/+OMuXL8c0TTZt2sQvfvEL1q1bx2c+8xkefPBBIpGIM/Gapum0Q1GhWLgsc90PIlBTuDnd7dDj8RAMBjl27Bjr16/HsizS6TT5+fk8+OCDlJeX4/P5GBwcpK+vj6amJn7/+99z8OBB5s+fzz/+4z9SXV3NunXreP7553nzzTd58skneeSRRygpKXHS9eHyqffpdPqqXVCKojgiTHx/UQpAVVV8Ph/xeNxxw/z2t7/lxz/+MYqisGrVKubNm8fkyZMZN26cc0zRv3OD66812le/+tWvXrezjQLC2pGbNikGU13XSSQSpNNpQqEQqqrS0dHBSy+9xMsvv8yLL77Ivffey9///d+zePFidu3axa9+9StOnTpFXl4elZWV6LruKE/RKES57pGKx7gjxK8WXdcdRS1Wxpqm4NEVOs+cZuuGN+nq6uFjjz5KxbhxmEDY7yPk0SAN6UQSb8gHio1qpjlx6DBvbdnGH33yc0yeUoEGWEZWnSpWBlQlGzeiDk1miNTeIauIbWbrkSga0onzwcmdjDRNQ9M0TNN0Vm7uiond3d288847/OhHP+Kb3/wmiqKQTCYZM2aMM9mLCS332COtvq5E7kottwaBe9Ur2r87Sr+vr49f/vKX/OAHP+DgwYOUl5czduzYYXECtzPiPuQO/LkppwJh7TIM45KJ9EZFiO3cAlxuS8HmzZv53ve+R2NjIwsWLOAzn/kMS5cupba2lrKyMmbMmMGcOXOIx+Ns3LiR/fv3Y1kWFRUVwxZo7hohqVQKr9c7rIiXENPua1IUhXg8jq7rFBQUEAgEiMfj9Pb20tfXR2dnJ729vXi9XsrKylBVlQMHDvCTn/yEl156iQkTJvC5z32Oxx57jNraWnRdp6SkhIaGBjKZDE1NTWzYsAHDMJgwYcKwRappmqRSqUuuSbx+tffXbf0UC1e/34+qqmiaxrZt2/jOd77DG2+8wcyZM/n0pz/NihUrmDNnjmPxARyLq+B69s8bvyV/SNydVVhC4OLg7FbU8XicV199lbVr1zI4OEhtbS3f/OY3qauro7a2FtM0GT9+PI2NjezevZuvf/3r3H///SxcuJDZs2fj8/mGrXRFdUH3D5ybynYlBgYGyM/PB3CsMGLVDAamaVBWVkZ1dTWH3ztGMpnEBjoudFFeWoKIGvDmDa85YRgG6WSKjjOn6RmcR1kIdF2UDfGAbWVdRHrWMjPiFQt3jXJzr95GE7e7xY2Y9IWZOx6Ps3XrVtatW0d7eztVVVV8/vOfZ926dTQ1NbFnzx4WL15MfX09fr8fTdOGWTFGEiEfZOUzkptAxKm4az689957tLS0sHHjRtLpNBUVFdTX11NSUuJ8v5t91X+tEGXOR4qLyA3yvNERq3+v10sqlULXdcdN09fXx9atW9mzZw/Nzc0UFRXx7LPPsnLlSoqKikgmk47gCoVCLFy4kKqqKhobG9mxYwc/+9nPePvtt7n77rtZvnw5gUBgmFAWFjj3/4V4zhUlfr8f0zTRdZ2GhgYikQhnzpyhrKyMHTt20NHRweDgIP39/c4CIZ1O88wzz1BfX8/06dOdDBpd16msrKSyspLy8nL27t3L9u3b2bx5My0tLTQ0NDB//nyqqqqcxasoiy8KvIn+ezV9RLwnkUjg8Xic+cw0TV5//XX27dvH/v378Xg8PP7449x9991UV1cPGx9s23YWu6PFLW8ZEQgh4h5MxYCYSCTYv38/L7zwAhs3bsTn87FixQruuecelixZQkFBgePjLisro6amhkgkgtfrZceOHRw9epS+vj6Ki4uJRCJkMhkMw3BUuTvOI3f1cyXl6V5pChGSTqfp6ekhnojh86vk5eXRf7aLdeteJW7bLFyxiuKiQnTAl91Jj0QsyStrf8uho4eYVFtDuqeXDW9sZvWjTzJlapUT+aGTrV0CNrrHM0xoDBk7h/6M7DOKJsXIh8BdBhsupt8JM7KiKGzatIkf/ehHbNq0ieLiYh5++GE+8YlPsHz5ciKRCPF4nL1793Lo0CEGBgYIh8MUFRU57W6kNvZ+LSSXEzXRaNTxu0N2gtm+fTsbN25kx44d9Pf3s2rVKp566imWLVvmCOvcFdjtTm6MiNtdPFJK681iUYrFYs4YJiwW0Wh0mPu7p6eHOXPm8NnPfpZly5Y5Y7KICxFjdV9fH0VFRdTV1VFdXY1t25w8eZJDhw7R0tLiWCR0XXfcgMKqKCyL7kWhoihOnJ9wSySTSVRVpaSkhOrqavLz89mwYQPd3d3ccccdTJ48GVVVCQQCzJkzhxkzZjB+/HhH1KTTaUcsWpZFJBJhypQp1NXVoWkahw8fZt++fXR2dpJKpSgsLHQWD6qqEo/HnceGYVwx3TadTjtzjBAypmmyZ88e1q1bx3/+53/S2dnJ7NmzeeaZZ7jnnnsIBAKOcBHjgxBA7j55vfuoYt8GxQjc2Qlu0uk0Bw4c4J133qGxsRFN05g/fz6LFi2ipqaGQCDgqMxcotEo3d3d7Ny5k+bmZk6dOsWYMWNYvHgx8+bNo6Ki4oormNyAvyth2zbNzc1s3rwZwzCYO2cmy1cshEyagZNdfOWrX+c/N2zgniee4Kvf+jZm0qA2L8j5Exc4cGgvh44cYN7iuaxYsoh3XnqZ//63X+NzX/6frHnojygMcFG8WBlUVcmqDztrLhnSNGRdNJmhuBIVFA8oN89K7UZEWM/c8R0nT57k9OnTrF+/3vEJ19bW0tDQQF1dHV6vl1gsRkFBAcePH2fnzp0cOnSI/v5+SkpKmDdvHrNmzaKmpmbYuYSL7/3sn3G5VL/c4LmmpibeeustWltbiUQi1NTUsHz5cmpra51Mn1Ao5HzP99v+b0Xeb8n+3HobN0L66NWSTCY5ePAg27Zto6WlhWQyyR133MGiRYuor69HVVWSyeSwLQ3ERnnuFNuBgQFM0yQSidDY2MimTZvYuXMneXl5LF++nKVLlzJu3DjHTQEMs1BfboJ1W54FL7zwAr/97W+ZOHEin/3sZ5kyZYojFIToURTFqTXivk4RXJtIJJyNLdva2pxA10wmw6RJk1i8eDELFiy4pJrsB9nO4ciRI2zdupXm5mai0SiVlZUsX76cO+64w2kr7vPkBsm696e53tzylhGxsnC7RwYGBjhy5AgHDhzg5Zdf5vz580yYMIGPf/zjLF++nLKyMgKBwLCob8MwSKVSzgDq8/koKCigqqqKadOmkZ+fT1tbG/v27eP8+fPObqrC9JUbQAtX7xOMx+OcOnWKd999l82bN7N//350XWfixPFUlBejmRa+gmKWNSymMxrll6+8wt7m93jrjbfY/vutvLZuPf3RXuYvmMfipYs4fqSZ7/zD19my611azvWRX1pJxZhKIgENXQFVVbCNDH39fQQCISckJJtJYwL2UCl4OytEpGXkQyGyTQzDYHBw0BlQtmzZQmdnJ+PHj2flypUsW7aMyZMnOxY3v99PMpmkoKCASZMmMXbsWFKpFG1tbbS2ttLW1kYoFHJqJrj3zrjaAedyq3FhVgY4evQoGzduZNOmTXR0dFBWVsaqVav42Mc+RkVFBYWFhU5BKPc5pWVkuCBzr0STySSnTp1yzOciLsK9ir1ZhNzAwADHjh1jx44dbNmyhfb2dsrLy2loaODee++lrKzMsYK4kwkMw3CyFkV70zQNv99PIBAgnU5TXFzMzJkzqa6upquri927d9Pe3u5YRoLB4LD7BlxipU4kEiSTSaePiL6YyWR47bXX6O/vZ9asWZSVlXHhwgVHIInYHdEfdV0nHo8Tj8fx+Xz4fD76+/sJh8OOSMnPz6euro5IJEJnZyft7e2cPXuWzs5ObNsmFAo5773a/pFMJjl79iyNjY1s3LiRQ4cOUVBQwPz583nwwQepqqoiFAoNCyB2xzi6GU0xcltYRgCn4fT29nLo0CG2b99Oc3Mz48ePZ/78+cyfP5/S0tJhA+blfHbugDMRKNXf38+pU6fYuXMn+/btQ9d1ampqePDBBykuLqa0tNT5vDDlXc0P3tPTw+nTp9m0aRNNTU2Ew2Hmzp3LvHnzmDihmkh+IKsSehMQjmAAf/+d79B29hyYEO04zx319Tzy6IPUz52JrRg0vbOVV37yM0IFZRzuTvKpP/lz5s6cStgLfhUsI5V10QAiWsSxjNgWYGYtIwqAb3TFiNN6hzKAFA2bbO2UiwG3gK1iK7ieB3ClKNs6KNnvZqNgDYVTaUOnSA99xmuT/e7q0IltBRQdY+hIHoyh+6RfvGmKBbYKytAOyWR1HDbE44MEw9nInvb2dnbs2MHBgweJRqN4PB7uvfdeamtrqa2txev1jihk3e00FovR2NjIrl276OjoQNM06urqWLhwIVOmTHEsfe9nI6xcy4hhGCSTSdLpNNu2bWP37t20tLRQUlLCsmXLaGhooKKiAq/X65xHbCgmnkun01dVUOpWx/3bJRIJfD4fqqpy5swZmpubOXbsGPn5+YwZM4aKigpKSkrIy8sbFph5I9PZ2UlLSwtbtmyhubmZgoICli5dyqJFi6ioqBi24MuN44BLrWfu+yVeM02TRCLBmTNn2LFjB42NjWQyGcaOHcvdd99NeXk5VVVVjtARGTbCsjE4OOhk5Zw5c4a2tjby8/OpqanhlVdeYd26ddTW1lJVVUVHRwd5eXk0NDSwYsUKJy7QHSwLFy1YIvZDuFzE9UajUaLRKLt37+btt9/m5MmTTJs2jVWrVjFlyhQKCwuvqn9cuHCBjo4Odu7cye7du7FtmzvuuINly5Yxfvx4AoHAsEJnV7PZ4PtdLH9U3DJiZKTBVQT/pVIpYrEYbW1tvPXWW7z77rsUFBQwe/Zs1qxZQ0FBAUVFRZesUN6vX1bsrNra2sq2bdtobGxkypQpLFiwgIaGBsrKypzBxn19uWZ6yKYH9/T08Oabb9Lc3Ex/fz8zZ85kyZIljB8/noKCAvx+L85kag01HFVlyHYBgO7+dbO74GX/bAAVU1GdOXOk3Wjc6c7ZG012cjUN0FRsU0XRLg4OcDEa/JqnhtkwEDXID+tgxcBMgi+PND4GMxlCHg9eMmArpDM6SQu8/qEdiOMZ/AGID3YTDOdBUgevBkSJGSaqtwQjA4Gs1qB36P4UmxaYCbCT2Voslo6l5xFToSdhMjaQxAskoiECAXFTM2BpWIpKQs0KHH+GrLDTVU6dPsXBgwc5dOgQx44dw7ZtGhoaWL58ORMnTrzibchtp+l0mhMnTtDe3s7WrVtpb2/H5/OxcuVKVq1aRVlZmSMw3IOpGKDdg5U7dRdw+lJzczN79uxh69atTJgwgfnz5zNr1iwqKyudjcOu1y6rV8Jdq8dde2Lv3r1ODMtoIaxiqqo6+61YlkVzczNbtmxh3bp1TlZVTU0Nc+bMYebMmYwdO5ZAIEAoFKKsrGzEehqiuua1RIxhIp1UZCT29/fT3NzMu+++S2trK5lMhjlz5rBw4UIqKysJh8MfiYtJ1OKBrEiOxWKcOHGC7du309TUhNfrZc6cOSxatIjq6uoRz2uaJvF4nOPHj7Np0yaOHTvGtGnTuPvuu/H5fBw9epTdu3cTDocpKytj165dqKrKn//5nw8TOYL3414ZGBigo6ODxsZGmpqaiEajTJs2jRUrVlBfXz+sZoj7uLFYzFm8HDlyhAsXLjBx4kTncwUFBe87Lmy0uenFiPsHisfjTlS/eC4ajXL+/Hl27drFtm3b6O3tdX5s4XsPBoPDGpQ7qOdK5O7QKDpla2srra2tbNy4kUQiwdixY1m+fDmzZs0iHA7j9/tHbLCWZXHu3DknY+f8+fNUV1cze/ZsZsyYQUVFhTOwXo9tni93DvcgdLn7dM2vz76ojazuNra/vYlTsSTBskoSpk60t48yn4qRSFNRW8eCO+eTUiDaD2PzgUwMvEO2krgGPg9nzjWzfde76KFaFDVMw5xZFJT4s2LEMKlAg9QgeBOg2SQvJNj53gk6lQjne8+y+o4xTK+aAEZ+VvcpFthxsL3g8xIFPIA/loZkkrf37abx4D6OHj1KKBRixowZzJgxg+rqagoLC684mbtNqu77LQbmY8eOcfLkSfbu3evENQnrRWlp6bCiUYJUKuW4NoUrSATWnT9/3mmbFy5c4P7776esrIza2loqKiouG2M1moy0i2pTUxPPPfccFy5cGKWryiKsG7quk0qlnMJwmUyGjo4Ojh07RjweJ5FIOAGaNTU11NTUUFRUxPz5852xwe/3jxj3cK1xWy9SqRR79+6lqanJcTONHTuWuro6Z++kj9Ii5j63GIvS6TQdHR2cOHGCN954g+PHj6PrOnfffTd33303ZWVljqsmnU477p23336bnp4e6urquOuuu6ivr8fr9dLZ2UlXVxc+n4/W1lZeeukl/H4/zzzzDFOmTMHr9Tp1fz7I4iuZTDIwMEBbWxvbtm1j3759BAIBJk2axMMPP0xxcTH5+flOCffz58/T0tJCa2srJ06coKSkhGnTpjFr1izHggofLOZkNLl5rvQyuC0KXq/XMUsZhsHZs2eHBZiWlpaycuVK6uvrqa2tvezA+X4UZe5koarZ7JbZs2c7ZXa3bNnC22+/za9+9StOnjzJokWLnFoLouF4PB6SySQHDhxg27ZtnDp1yqnkt2TJEubPnz8qKtddMEg8Fh1ZfN9cs95129tAyYawWOkMradOs/713/Nvz/+C3hSUT5pKwBfA6u2kLFKArfj546e/wJ/9tz8lL0K20qydFSK9Xb2EAmV4VZXWY218/1++w65dR0gT4t9eeIWP3b+CUm8cr66QJoBphgjYSejv5cfPPc8X//YfscxNzNAAACAASURBVAPlPPWXf8b9iz8BmGSS4PGCmUqhhTxg6cTjSYygHw0423GKxq3b2LynCSXoo6amhrq6OmbPnk1VVZXzFa+0VhipBoXIxBF+Y1GrYe/evRw8eJBf//rXHD16lEWLFjF79mynzoGiKI6vGy7+zmJA3rp1K9u2bSMajTJ9+nRWrlzJ0qVLL4mvEtdyo6Tvuv3k4npEpeT169eP5qU5wckiSw5wYidEsTBBJpOht7eX/Px8ysvLnTROd9VnEVx5vQpWuYXe2bNn2bZtGzt27CAWi1FYWMjcuXOZO3cuU6dOBYa354/iGt3jrzi21+tlwoQJVFVVUVVVRVNTE++88w5vvfUWp06doqGhgalTpxKJRNixY4fjZiwqKmLNmjXMnj2bCRMmOC5FYRE5e/Ys7733Hul0mlmzZlFQUOD0FV3Xh8X8vB8hIDbXKysrY8yYMZSUlDjZcSdPnuTOO+9k5cqVRCIRTpw4wa5duzh+/DjxeJy5c+cybdo06uvrL7Hy3UxCBG4BywhcOvl1dXXR1NTE3r17OXPmDLZtM3XqVO6//34mTJgAXNwhUpipP0h1SnHu3Dxtd0VN4c9877332Lx5M83NzUQiERYvXszs2bOZNm0aqVSKw4cPs3XrVpqamrAsiwULFrB48WImTpxIUVERkDW/p1IpwuHwJTn01xJ3xxK1L3JNk8LUfN3N8jZgmKClGew5ww9++L9478QZPv70X7B62QqsaB+9p0/z7W9+i627D/GnX/o2T/zxSsLRPkJ5eramCh5sVDLpJHamn86zp/j3f3uOb3//x6x44gt87St/x/xaD9gQVbMdPi/dT0vjVp76zJ+zp+0cf/vd/80ff+YxJhak0M0MVrwUTQXFD6gpsD2YqkoMyFgWh17byObXXifl99CwdAnLli2jsLAQuJiudzX3Mte9597GXKT7CUtfMplk9+7dbNiwgZMnTxIIBFiyZAlz5sxh+vTpaJrG4OAglmU5gYPnz5932uaRI0coLCzkzjvv5M4777wkU0ecX0wyN4KLxk0ymcSyLMd10dzczL/8y7+M6jUFg0Hn9xYTmaqqdHV1cfToUWzbpqCggNLSUoqKiigqKqKystIJWB4zZgx5eXmXWEIu108/aoSb5NSpU7z44ovs3LmT4uJiFi1axOTJk5k5c+awiqPpdHrYlgAfto24BY2w5okxMZ1OO33h5MmTbN++nQMHDpBOp4lEIgSDQXp7e0kkEtTU1HDfffcxe/Zs4OKcEo/HndLvO3bs4Ic//CHl5eV8/vOfZ9KkSY4LTXxGxIm8HzFimqbzW4nvcvjwYZqamti8eTN5eXlEIhEsy6K3txdFUZgyZQozZ85k/vz5jmUznU6TyWRG3KrkZuDmu+IREI0wkUg4walHjx4llUoxd+5cFixYwOzZs/F6vU5kughecpeGz40TuRrlLoryiGh3N0IwBINBFixYwOTJk9mwYQOvv/46a9eu5fDhw9TU1GAYBq2trRw/fpyKigruv/9+FixYgN/vdzpuJpNxVLrbFH89zLHuapBi4MxFTHpugXQ93DRgMTjYR6ggn1BJKWPLCtl7YD+9vd30G1CeV4CvIsNjD97Dm9ve5rnnn2f5mpXMLg2BNUg67SVpmgQDKqg2vmAB48b5mDiugkfuv4s3d23mvYP3M798AegaKRs8GkTjafYeaGHypCnEzCAzptdRVBAgnRnA6/Gh+gEDbCPDQLQb3RPEFynAAvoG+vGHgixdtYKqKZOpqBk3rKy1CG6+2nWCO8YpN8vCHfMTDAZZunQp06ZNY+vWrWzevJm1a9fS2trKokWLmDVrlrOx17lz5zhx4oQj6hOJBMuXL2fNmjWMHTt2mLVBtHNxve8nbfhaI+opiGJb7kJPM2bM4F//9V9H9frctS3c9/TMmTMcPnyYTCZDQUEBZWVlTnVQv9/vZJ8IhAgU9/56FUcTE/GZM2fo7+9n0qRJrFmzhoaGhkv2oNE0bVgMy0fRRoR7JLdGBjCs2NqECROorKxk6tSpvPHGG7S3t6PrOuPGjeOBBx5g8eLFwyzlIuvMvdlkf38/PT09BAIBjh8/ztGjRwGorKxk3rx5TqC2yOC5mvFPWJaEgBHfYfr06YwZM4a6ujonKNcwDCZPnswdd9zBvHnzqKysHHYsd30iuPlS5296MeI2EwoxcvjwYcrLy1m2bBlz584lEokMC04VHeNKVpCrmQzEJJB7LDE4i0la1IT4xCc+weLFi9m4cSM7d+6kvb0dw8hWUX388cdZsmQJlZWVTmAb4AxWbl/r9fQHuu+DO5e+p6eHeDxOWVkZXq/XiRwX9+Gar8yUbFn6QCiAiYaCQjzag0dJU1Y+Br8OKRtC+flMnziOsaURrOIi/GGANAxG0fIKMJJgYZFMxPD68jnXfgYjk+HZZz7F2//1b9m+cR0LaiuZOnMG4aGMnObjJ9hzuJ2VK9dw8PhPGOzvwwOEPD6wrGz6jQcU3UOkpBjwEDMNkppOcUEhk5YthUQagl5QLmaoiD1lxH2/0mCWuxVB7uDj9XqdlZcYqEpKSrj77ruZM2cOmzZt4uDBgzz33HNOCnFZWRmHDh1i586dpNNppk+fztKlS5k1axZ+v99JbYThRaSul6Xu/ZArQIQbQ2zzPtoZPYqijBhkOnXqVGcc8Hq9I1o+3Cmq7uKKQpReLxeZYRiMHz+eJ598Er/fT2Vl5TDrsBir3G5euNTF/UHIFTxu16DbJQfZBdP8+fOprq6mp6eHdDrNmDFjKCsrc46TTCaHpcJD1jri8XioqKhgxowZnDlzhvXr19PX10dBQYFjuZg4ceIwC/tIsUq5CMt8bnaP1+t1LGElJSXMnTuXvLw8JkyYMGzhkkqlnNCEXFfpjeAifT/c9GLEPfgFg0GmTp1KXl4eEydOZNasWUA28jiTyQxLlxKpVn9o8LyaznK5IFQxAIpKgqL4TSAQoKqqivvuu8/ZA8G2bSZPnszixYvRdZ3BwUEAR5XnNjKxydRoDPzuYLH33nuPd99914nDgetdtc+CTALV6yOFio5O2O/Fo1gkEgkSQEgBO5ng1794nsGBbhrmziNtg5mIMdDVxV/+t3+mcuIUvOZpGre8wVOPPsvjjzxM9cSplBSG+ezHGnhj66u8VreMqvoZhIjRN3CelvYO7EAJs+fcQUXJa1ipDMkEKAEAk+9////ll//5W6KpUyh6hmQGwmUVrHjsUZ7+9KcoLCgalrokSl67rUq5LpjL4RbE7n1shIVFuF3Esfv7+wmFQowfP57y8nL27NnDjh07aGlp4bnnnsM0TfLz8ykuLuahhx6ivr6eMWPGOKJnpAA5MQiLCUH8jba5WEzMwnIgrCQfJFvuWuAuQmdZlrMxoq7rhMPhEQWeuLfi93YvhkS83PW690JAl5WVUVZW5jzvFiC5Af7CmvFR4rZyu+tK9fb2Om5uyAqTcePGMW7cOCfbSJRmiEQiTll4t1XB6/Wi6zrTp0/nySefpKWlhb6+PhKJBCdPnmTPnj0cO3aMiRMnDrvnVzsOCnEm7lduQLkIWBa455eRhKw7dflm4ua62hHQdZ10Oo1lWQQCARYuXOi8JlIWxY/r9hmLjedEoxUrO+GaeT8DVW7+ttv/6+50gUDAccls2bKFpqYmTp8+zQMPPEBVVZWzW6MQIe60Nfd53FteXw/c5xLfMZFI0NbWxquvvkp5eTnTp093grhEp7ouosSjYdsGMRPydPD5Pezd/S7b/p+voIS+R76VIi/Zja/3JF/6m79j7mc/iQ20HjzC3/zVf+HFt05yx+p7+eRDc3j0kYe4a9UaotEEx1rbWXbnx/mvf/IUL724nq27DnLPo48zOdJPz9k2BpMpZs5bRDAQJNrfi22ZRAIQHezj5V/8iu1bD2ZdhHc+wf/3/L9z4OARZi5awrIVyyksLMKyQfV6MTIZFE0dJi7F7yxWTX8IMTC525m7vodpmsN2StV13dkYS+x71NDQwKRJkzhx4gQHDhygq6uLKVOmOPVCBKJd5xZN+zAxV9casQAYaWFxI2zUJ+6nEE3uiSiZTF62r7tX/6KGksjmEO3melhPxfgkrGXCOqeq6rAdc8V4IEqpw0cTwCraP1y6DxlAUVGRkx0mziuChoPBoJPq7Q7adgcUW5blfEePx+NkLomCf+vXr2f//v0MDAxccg1Xs5h1W09EjIu4ThHQ7PF4HOEpri83TkxUeBXvFwLnZuKmFyMw8oZSwCWmq1wLQ25HHSnu42q42g61e/dufvrTn3LhwgUmTZrE9OnTmTJlCufPn+cb3/gGkUiE++67jyVLlhAMBm8Ys5vX63U6rXvjKrHJk9ip0jTNYTn/10WZKzaDsRiWNzvB2rZNOD+PyXPnUlQ1jYidROk6wYld/bz+6nqO+Ot4/IlVJBMxFi5cwMZDGUrKxvL4Y09QU14CmTBnj7ZTVlxCtH+AkjGlPPv5z/Gz7W289tpGpn9mLi0tLTQ2tvOtf/wW7dvfIuC7mKZ94cIFGhsbgQB//dd/zbiphUyrn8Ijj/4xK1esYk79LDxkNzzOxBN48gKXFHdx/85XmiwvJ/rE59ztObc95efnOxNIaWkppaWlzJ8/f8TjXO76xHty3zfak7zAHQfgvhc3kgn7cv0k9/cS5N7bkdxz13tlnDsGX81i5KP4DS5X+M19j3Jdce42kVufxX0f3UXSxAQvAnA1TePVV1/lZz/7GcuWLaO2ttb5vLBOXo2LOncR4Sb3/5f7riP9/jdTrIjglhAjNzKiIScSCbZt28axY8eYN28eDz30EHPmzAGgtbWVrVu3snPnTl5//XXy8vJYuHChU0RoNBErS9FpX3nlFd58803Ky8tpb2/nxIkTfPe732X8+PE0NDRw3333OcLkg4q794VpEQ5HUAmgkiCWTFE7YQqPf/opGhYuIt0XozKi8d4bi3nmL/47P3jp0xQVv8Kzq+8gpKv8+NXjzJo5k4ryWgYGOglZGsXFEdLxQSwLKK5i7oKlfPsn36G74zjH20rZ2tjMgjuWkR+EgN9DPBGjq6sTgAm1E6mqquLE0VMkk0kwsgNTKJTHmTNniKXSeHxesMETvPFqckgkkuG4LS/C4tLW1sbBgwfRdZ0FCxawYMECIFv4MhAIOLFaN6MoGC2kGLnGiJ0YN2/ezIULF3jmmWd45JFHgGxg1P79+6msrOTJJ5+kqqqKN954g3PnzgGMuhCBix1QBFZ1d3dz8uRJp2xye3u7E5OQTqeH7Vp5XTqi4sHGRsMgZQwymDRJmgqDgwk0oCgSBjvFtEXL+ML/+Zec+N+vc6rtKOmBCNFoFF0x6O3uImlCXn5Ztlhqop/OjnaKCv+IRCLEnR97nFXzfsOW3/2EY23vUlBazJ/etZJEVxepwQHGjh1LTU0NF3rj+AsMHn/8cU63vcSXv/xl5i+ZwpHWZh544AGeeuopCn1exxBy9sRpKiZU/qFvJ5FIRpFcN6lYaEWjUZLJJNFo1HHT9Pb2UlxczOrVqykuLpZC5H0ixcg1Rvj39u7di8/nY+bMmU665dmzZ/nud7/Lww8/zBNPPMHq1audlL6SkhLmzJkz6oJExH/Ytk1eXh7PPvssf/Znf0YikWDt2rW88sorPPHEE6xZs8axnogAsGtfeEkFVQcsdDL4dC/lVbUUl3dm/fCAVwEslfMnzvLGpq2cPdqC10rjzQ9TXl7OYLSPsqJCVGAgZpJPBkXNMG3aFLp64xSWFmMAD967lL/9ylfZfuwk/8df/lfCAY1wJEBRcR5Hjx+lq/cCxYVBNBJ4PDrBcJDUqfPs27cPr1/h6aefpqZqLBeAwViS0qCfippK93bIEonkBiPXuiv+X1lZSUNDA8ePH+fdd99lw4YNqKrKggULqK6uxufzOW5sydUhxch14Pz586xdu5aHHnqIyZMns3//fnw+H8ePHyeZTLJr1y6CwSB1dXWUlJRw5MgRWltbufPOO0f70h3fq7DwCCtIMBh0tokvKipyAoJFsatgMHjNg6hsVAZTCVTVJjXYxb49jbzy6kbeaz2Nr/Jd8sJFhJNxkr3neH3ty6x79U0a7rybu1fcSaqnn5///OckB/s52XqUwwfPMm9WBdHznWxY+zIth5tpPHyaZY/nMWfuJB7/5GO8tWMTZRcCPPrxR/FqCmeO7Gfzlrc419nJzsZGJs6YSKmvizfWvko0avHXf/3X4B3AIkW0f4C1637PigfuIRT209edpCB/5JgAiURy4yAsve7dk8vKyli8eDFTp04lFosRi8VQVZXCwkLGjBlzSUaM5MpIMXKN6erqIhAIUFJSQn5+Po2NjXz5y19G0zTi8TgtLS0cOnSI9vZ2Vq1aha7rdHd309PTM9qXDmT39hEFowKBgOM/1TSNlStXsnr16hFrNYgKkNfaVOn1hdDI0HG2g/Wv/Jbfv7WV7kGL410/5Wf/8TMKlQyp3i4CoTCf/Mzn+Ntv/TPFES/7N/+Ko61t+P0eNr/5JpFAhIl/9z843HyAf/rX/0VfV5SC8hqi3lKqK58lUByiYeVqJiUizJ5US2bwBP/27z9i06sbCIT8vPb6erqiF/j2lz/H+PHj+dmPf8KWzTvxhBKkMjE8egg1vwDPmAqWza8nP+TPFiyRllyJ5IbFHfeRGzhcWFhIfn7+iGOcqLwtRcnVc0uUg7/R6erq4plnnmHu3Ln86Z/+KYcOHSKVStHe3s7Pf/5zZs6cyT333MP48eNpbW2lo6PD2VH4RkSUdfb7/aiqOmzHV5Hydj3MkyaQAXQM9Mx5Tp5oI67mUzFhBhYaAxdieOO9lOSH8YQidPb2UzCmENtKo0VP0NnZhV44CX+glADZvWRQE3ScasXjr0DBR2lBCPzQZZuoikJBEjQd0OPEejpR40mCJdW0xhRSJJlWYvHSr39NsreET33yEwwk+1A0g1CwkO37DtCRTDFlwkTuKCnJumh8ZHf2HSXez943EsnthjsrUAgTkWLr8XicitQirs6dAXPJjueSP4i0jFxjMpkM4XCYhQsXOnEUq1atIpPJcObMGXbt2kVDQwMrV64kFovR1NREaWkpkydPdgrxjCai0JXb+iE2+BM1DtylrP1+/7By9dc6vVAFDNNE94SonlSHSR4ZNKJJi9KiMMHiIKTSoKsEwyE0smm1aqSYseEiUlYeug6aCbG+FOFilaraScQSPkI+UDImmZSJ7vOiAppmgJnGMA3CRWMgzwTNR3mJB5sQ63//c174xa949IEvgAb5hfmgWpw8cYauznNUT5rCtKqSrJJKX9NbI5FIPiQi5i13c1Axxokde8VjyNaHgcunZktGRlpGrgOxWIz29naef/55CgsL+eIXv0ggECAajfLaa68xffp0SkpK2LZtG7t37+auu+7ivvvuuyHLa99IuBuuQmboOQ1ryNSgAsrwNw3Fi1pk1QBkN8nLVpZHEQ+y8SjOZ5WLusFrA7YFquVcRDqdwdYDaBqcO93GD7//A155+XWSyTThsJ9kKs6EiZN5/BN/zH1/9HFKSwrRbS4Gr8qfWCKR3OZIMXKdSKfTPP/88xw6dIjp06eTn59PTU0NXV1dDA4Okslk6OzsJJVKsWLFChYtWkQikRix3K/kxsItGi3LYv/+/Rw7dsx5LZFIEIlEqK+vd3aNFlUzR3tvFIlEIrkRkGLkOiAKn7W0tLB37166uro4f/485eXl2LbNqVOnCIVCTJs2jQkTJlBXVydNfDcJ7nLOI22MJdKcVVW9pFy12G5cIpFIbnekGLkOxGIxJ6p6cHDQqSUi8tD7+/spLy9nxowZ5OfnO5/L3ZtGcuPhDlKLx+NOfQGB22oiBYhEIpGMjBQj14HcssCZTIZMJkMwGLxkHwPLskilUs527zJm5MbGXdjNLTzEb+7+7cVmYrmbckkkEsntjhQj1xj3ZOXeLnykjJNUKjUsM0Vy8yBcMblixE1uRdqR3DoSiURyO3LjbF15iyK2uM5kMo7QEFu79/X1DXuvpmnD4g8GBwdH45Il7wN3lVmR4idEp0C4Z3JL40shIpFIJFmkZWQUSKVSI5rq3Y+v/b4uko8C92+Za+kQbhshTNy/s/v/EolEcrsjxYhEIpFIJJJRRS69JRKJRCKRjCpSjEgkEolEIhlVpBiRSCQSiUQyqkgxIpFIJBKJZFSRYkQikUgkEsmoIsWIRCKRSCSSUUWKEYlEIpFIJKOKFCMSiUQikUhGFSlGJBKJRCKRjCpSjEgkEolEIhlVpBiRSCQSiUQyqkgxIpFIJBKJZFSRYkQikUgkEsmoIsWIRCKRSCSSUUWKEYlEIpFIJKOKFCNXIJVKARCNRp3nuru7sSwL0zQBSCaTWJYFwODgoPNYvC6RSCS3Kr29vc7jTCaDaZrDxr6+vj4AYrEYmUzGed6yLGzbHvZZMXaCHD9vNxTb3RokI2KaJpqmYVkWqVSKQCDgvBaNRsnLy7vk/ZlMBr/ff70vVSKRSK4blmWhqtk1bTKZHHHM6+vro6CgwHl/PB4nHA47QkRRlBGPbdv2ZV+T3HpIy8gVMAzD6TSGYaDrOpC1jvT39ztCJJPJ0Nvbi2EYaJqG3+8ftmKQSCSSW414PO489nq9QFZEJJNJx0KiqiqGYZBIJFBVlXA4TCqVQlEULMsaZg2B7DhrmqYUIrcZ0jLyPnBbQd5++20qKiro6OhA0zSmT59OYWEhiUQCRVGkVUQikdzyCMuIe6EWi8UIh8NAVlgcOXKEeDxOX18fkUiEadOmkZ+fP2yRpyiK8/lMJoOqqmiaNjpfSjIqSDFyFUSjURRFIRwO09fXx+9+9zt++tOfsmPHDioqKlAUhcWLF/NXf/VXzJ49G4CBgQHC4bBjwpRIJJJbERHr4fP5SKfTjoXkxIkT/OY3v+H5558nGo2iaRqpVIpnnnmGZ599lqqqKucYwoIirCWKokjLyG2GFCNXIJFIkE6niUQinDt3jk9/+tMMDg7ypS99ifr6ekKhEO3t7XzrW9+io6ODf/iHf+Cee+4hlUrh8/lG+/IlEonkmpJIJAgEAo6LWlEUNmzYwAsvvMDZs2f5kz/5E+655x5M0+S1117jxRdfJJPJ8PWvf526urrLig4Rqye5PZDL9isgOtnp06f59re/zfHjx/nEJz7Bxz72McaPH4+iKDQ0NPDFL36RYDDIf/zHf7B//34pRCQSyS1PKpVyBIOwaJw9e5Yf/ehHbN26laeffprHHnsM27YxTZMnn3ySp556igMHDvBP//RPtLW1kUwmneMZhjFaX0Uyytz2YsQe+hv2BBbYFtgGtmVQXFxI14XzrF27lklTJvOZZz5P2rIxTJvS0mLAYmHDfFavXs2WLVv49W9ewgYSGcM5/nDzk+X6k0gkkpsPGwuvT8PjVQGLRDQGFrQcaOHA7oMsbljGPfc+gAmE8vMpKi4EMjywZjkP372CN373Mi1Hj9PZG8UADCCVNpyxUtMULjdWXjqmSm52bmsxYnOxmdviCSywLLAzYGdQFJNoTyd7mho5c6aDu+65Fz0YxPZ6sTSFRHQA7AzBYIDKseXYqBw60sL53kFUj04GyLjP4QidDNgmUpBIJJKbEQuLFAkypDCMOJGCAsjAht+8yoUTPSxbvAaPPw8DSGJjYWInetG8GRaPL8bo7mXDG1vQC0tJAkkLPEE/8dSQdcQYGiNtMztmDo2Vl4zbkluC21qMjIgN2LbT+O1EDF2FRDLuZMt09/SiKDAQTxLIC4FtYaaSjB07FsMwaGs/gcfnH9Zh7NyT2NIyIpFIbm5MLMBE1zWIxSGaxmvrKKZKJm2iebIWD1BIkUYJ6JCOM7YgjxkTyhiIDhJNgglYqnuctOAysSQjj6mSmx0pRi6LCraK4g+SSmU4deoU/f39RCIRKsrLUcgGWA0ODICiovl8VFdXM3nyZEzTJDbQj2GAQvbvEhR56yUSyc2Njk52GlGxLItMIo6JiUmKvPwAug6xZLbqasY0su/1+ikqr+ZCb5S0aZFJpYeNkU4Gosymua2QM+JIKAxTEeFwmCVLlpBMJuns7MSjQv9gksK8EKG8CACJaJRDhw7R29tLXV0dFeVFyDwliURyq6ICCjppIys21HAAT9hPKN+HotnEkv3YgOLJunQ0TScxmISkzUDCojeWpKKiAq+uZodaO2uU9niGpiVLWo5vJ6QYyWWYGFdJ9A2gB4PMmTOHyspKmnY1MhCNUxjKumGwbTBNAnl5tLS00N7ezvjx4wHQ1ctYRVzHl0gkkpsTFRUVLAXsobEs5GXOHfVUVBXz2oa19ET7CWgeopkYacvCHypkMG7w+ltvEyooY+7cueSF9aywGdIeytCxcyuz5iLtJrcWcjZ0I1q3ogBZJREoLABULNPms5/9LKdPn+YbX/saCqADqXQKNA/bt2xl/fr1PPzwwzz+2KP098XQh1LkVXI7ztDxJRKJ5CbGxibkzVZbNRODoJgsXbGYlauXsXvPO/z6Nz8HDLweHZ8awETjpXWv8et1G/nYg48xe9YcQr4hQ7Qy3DNjqxqgXKI6Lh1PJbcC2le/+tWvjvZFjCbCk3LRKzMUGqUMfzaSn0/97DkcO9rKa7//PcFwPpqqE4/20bxvH//zW9+it7+fb337O9TPmkHGsPB79Yv6xvmzh59VuWxUiUQikdywKChg26hD8W8qgKbgCQcpKY0wkIjSuG83ltdG0z2cP3+edWtf5ze/fJnJE6fzP/7vr1BeW4GmDUWdKNkFngbZ42oq2bHy4uLQPUqL/8nR89bgtq7AKr64hUtti/ReEbNtmqDpGIYJikJf/yD/+etf8fxPf07XhfNYqTiYBg89+hhf/spXKCwsprunj4KigmEdRthBFJusPdIWNkkVaSWRSCQ3K7ZpodgWqDaYGVAt0BTaO07ws9/8hv/1wx+CqhP05ZHnzeOR+x/mK//9b0ikbLwFCmkLPOrFvhlNtAAAIABJREFUcVIDjEwGj0cb0iJihAZQh2XRSCFy6yDFCBfFCIjGPSRGbLJBVKqKZWXfrWoeYoMJTp8+Syw2QEF+kEQsSnllFeG8PPz+IBnDQtVVBuMpQsFsJVYpRiQSya1GtgxIBlXXQDHBTIGeHUXTVppzvT30xwaxFS/dXf1MqpmCmbCoGVuMYYDtvXgssSC86IYZKWZEipFbFSlGuJwYGfrXsEHTME0DywSPL9t7DCNb+jg+2I/f78fj9TpH6euPEonkDTvuxWO7jw9SiEgkkpuSoQHUNgwUTQXFxDbTKNnNdzEwAQ8WKhlsEnGTQCAEJvj04YcSY6Oa8/9LBYnqPrUUI7cQciYcYniBMmGtUDHtrFZXGIpGtSGdTJFOJtBUhby8AjxeP6lUhp6eHgAULCzTdBT+pX5N1fUnkUgkNy+Kqgy5UpSh8VIHdCxTRUFHQ8OLj4JgCJ/y/7P35sFxZdeZ5y9f7gAS+0qCAAiCIHaSQAEkuLMI1qIqSVVFqawoSwpHjC3bsh0zXjThsac1ane4O7odtmNCbtmOaXc5yt0KuVVWrSxWcRMXgAtAbARIgAABEsS+A4lE7sv8kbyXLxPgUgIIklXvi2AQub18+d695557zne+E858A3g892yjsIYPtpX37KXGFfniQVsNHwjV4NfpMJpMOBcXudjQwJnTp5kaHwcdOJ1OPvnkE86ePQtAfHw8odDdonkNGjRo+MLiLlcEQAchnY4QekLoWbA7OX7sOM2NLYS8AfTA+Ng0//bzn3HrzhghApIjojkXGjRnJKoJU7SEu2IwEAiGZM27a3GRxkuXuVB/nsnJSXw+HxOT05w7d47m5mYg7LjoFQgGfEuOL6DJGWvQoOGZhm6pbdMpJsCAxxtgbmaRjz74hMaGJkwGA7ogjAze5u9/8mMGbvdgMevRRTTC0+zklxmGh7/lyw1R9+73+9EbDBAMMTc3h9O5SEKCDb3eiF6vZ3FxEZ1OR+BuDFKvV9Armq+nQYOGLzLuRoDvEvF1KAQBv0+Hy+Eh5NExNzkTbj7jDxFrNjE5PoxO8aG727Um7G3cLacRlbwavnTQVkuJ4JJHIkKi1+vQ6cKcEYPBQGysFavJjEHRoyig1+vRKQbMZnPYIfF7H3h8zdPXoEHDFwdB0EEgFPY5ABSdCUImkuKTsJrjCLn8hAIB9DqFlORE4mItuLwOwppOqj68y0RbYLkIidZo9IuGL7UzEtGcaZn/FSAQCE8BvTEcRNLpFSwxVvyhIFMzs4RCITweD263O/w5RUGvDzsuQcHU0qBBg4YvInSEoyKhcFRY0OSMRjCa9ExMT2GzxaKzGtBZDYyMDeNxuVFCYDWFZQ8IRdfSaPgy4kt/93V3+yuE/4+sc9cBBv3dTglKWPrYaDZjdzgJKnrMVis6nQ6TUY/FbLyXojGEy3x1yr2OlssxwbVo5MoRUDl8wWAQn8+37Pv8fj/BYBCn0wnA7Oys/AxAKHSPF+T3+/F6l4tuadCg4R4UQkEd6AwEgmAyGDGp1FT9QTemOAMzi9NhlqoCtoQkdIqBgFeHLmgE9GFnRvfgqpn7V9k8GB6PB4D5+XkWFhaA8FzX8PThS++MgKolTdT/yyGki/yn4clCr9dLJ0RRFIxGIxB2MrxeL6FQCJfLhcFgQFEUYmJiAEhISIgwSuq/9Xo9Oq19uQYND0XoPs4DugAhfIR0fgJKUO7wwjYz2vF4fDIHiqJw69YtmpubmZiYAMKbDc0hefqgOSMannmEQqElxkU4JoJUHAgEWFhYYH5+nmAwLFin/oz6sU6nQ9HIxxo0PPOw2+2cO3eOkydPMjAwwOLiIn6/X9tsPIXQLK6GZxqBQAC9Xo/JZCIYDOL3++VrwsHw+XwsLi7icDgwmUz4/X6cTieKosg0j06ni2hZriiKtnvSoOEZR19fHzdv3sTpdJKcnExsbCxWqxVAS8U+ZdBKezU80/D5fJIwLFI1EDY0g4OD9PX1MT8/T29vLzdv3iQ9PZ28vDxSUlLYuXMnVquV1NRUgCWREg0aNDzbSExMxGazMTo6yoULFxgYGMBsNlNRUUFmZuaTPj0NKmjOiIZnGiZTuFeQiHAIzkh/fz8NDQ00Njaybds2SktLKSwsZHR0lMTERK5du0ZDQwO//uu/jslkIj4+HkVRCAaDWopGg4YvCAoKCqioqGBycpKOjg7OnDmDoih861vf4mtf+9qTPj0NKmjOiIZnGiLV4vf7MZvDpYLT09P09/czNjZGbW0tlZWVbNmyhaGhIRoaGqiuriY1NZX33nuPa9eukZSURHx8PAaDISJVo0GDhmcbfr+fqqoqsrKyWFxc5NKlSzQ0NNDf38/c3BzJyclP+hQ13IW2BdTwzCMUCsmIiNfr5fbt28zOzpKUlMQrr7xCcXExZrOZoaEhfvazn6EoCnV1ddTU1DAwMCDLfAEtKqJBwxcIRqORtLQ0KioqqKysJC8vDwiX/GqOyNOFx255hb7Dw97jdruXJQyqCYnBYDDiWKKGfCVY7tyivwfCzfB0Ol1YFl6vx+PxEBsbSygUwmw2y+oNIX4WCATk+6N/l0aMXF2EQiEURcHv92MymRgfH+f48ePk5uaSlpYmiWqxsbG4XC7Wr1+P0+nkjTfewGQycf78eaamplhcXJTHVP+tQcNaIBgMEggE7msvvV5vhK4OPNi+ivcGAgG8Xm/E+6LJ3is5Z0DytsQxA4EAZrMZv98fYQP9fj8GgyGC3xWt6xMMBlfNRopjzc/P89FHH/Fv//ZvpKamsnv3bvker9cr1xKfz4fdbpe/QSD6uqshSPLiXiy3fqwEoVAo4hwFHA6H1FWKXmc8Hs8zF+V97Gkag8EgtR4gnOMXAzcQCOBwOEhISMBgMHDnzh1cLhfp6ekkJCSgKIocuF6vF4vFgqIoeL1e9Hq9DMuvBGJCqCeAoiiSwOhyubBarRgM4Uslvtfn83Hnzh2ysrKYnZ3F6XSSmZmJxWIBwoPBbDbL3y+cGJ1OF1HlITgPGn41BINBGRXxeDx4vV50Oh2JiYmYTCYaGxvp6OggOTmZc+fOkZeXx09/+lOSk5N55ZVXmJubw263Mz4+zqZNm+RxLRYLXq9Xuz8a1gzCFqkF+ETVl9VqlWPR7XZLxzsQCMjqEBHhS0pKApA2B+5VlglOlPi3Ugi7KHR9xPeJzUFCQgImk0naOr/fTyAQkOuB+hgCYSXXkCzNXwlCoRBut5vPPvuMzz77jMrKSr7zne+Qnp7O4uIisbGxmEwm6QwZjUZ5Pj6fj6mpKTIyMtDr9fK8Y2JiUBQFn8+Hz+fDYDAssRMidRz92z4v1NWCfr8fh8OBwWDAYrEQFxfH3NwciYmJGAwGnE4nPp8Pi8WyKmvjWuOxOyMejwej0SgnjIAYcLGxsfh8Pj799FPef/99bDYbhw8fprq6mvT0dCA8sC0WixzooozT7XbLxX8lEDsSnU637MQA5M31eDx4PB5GRkY4ffo0J06cwGq1Mjs7i8fjYWpqitTUVCmuJSa/+rjiOW2hWznUpFO9Xo/X68Xv92O9q457/vx5/vmf/xmTycTo6Cijo6PcuXOH/Px84uPjMZlM0khbLBZ8Ph9GY7j54f3UXDVoWC0Iu6N2DMSGBSAuLk4+7/f7ZYn61NQUU1NTbN++HafTSWJionRCxEIvbK5er5e2c7UhNHuEjRbw+XwEAgHGxsbQ6/X09vbidrvp7e0lKSlJRpU9Hg8GgyHCaRKbCzEXVwKDwYDBYCApKYnExET0ej2dnZ1kZGSwceNGudl0u93SBiwsLDA0NMTo6CjFxcUMDQ2RkpKC1WolLi6O+fl5ueBHn5+IUBgMhlWpyFMfw2AwyPHg8/mYn58nNTWVhYUFrl+/zuLiIlu2bCEhIQHgmdtMPXZnRCziYscqbp7wLFtbW3nnnXc4duwYmZmZ5OXl8dd//ddkZ2fz3e9+l/LycjIyMoDwjV5YWJBRk9VwRERYUa/XRxiEUChEIBCQN9/hcOD3+xkfH8ftdjMwMMDg4CDbtm2jt7eX7u5uSktLZR5SeN3Ruw+RUtCwenC73ej1eiwWC0ajUToTk5OTfPvb3+Yb3/gGZrOZDz74gL/6q7/inXfeoaSkhKtXr5KQkEB2drYs81MbwGdxd6Hh2YLsY3V3UV9uAXM4HEB4Mbp69Spvv/02Z86cYXFxkYMHD/LNb36Tl156iZiYGDwej3RChPLwcgv6akVmBYH8XrfysOMjogVOp5Of//znfPDBB9jtdkwmEy6Xi+npaXQ6XYQNjz7f1bCT8/PzJCQkkJubS1ZWFqdOneLHP/4xKSkpHDp0iN/4jd9gy5YtxMfHY7fbuX79Ou+++y6nTp1iYmKCrVu38pWvfIW6ujoyMjKwWCxysRdRCQGRYltNBWf1NRBpIEEJSE1NZXx8nJ/97GccPXqUnJwc3nrrLRISEoiLi3umHBEA/Y9+9KMfPe4vETtMcXEcDgeXLl3is88+45/+6Z8wGo0cOXKEH/zgB3z961/HYDDQ3t7OqVOnmJubw2g0kp2djV6vlwsNhCfUSm+6TqdbMnhEiFSENnU6HS6Xi7Nnz/LOO+9w9epVamtr+ZM/+RN27drFyy+/jKIofPTRRzQ0NJCcnMzmzZsjjimkydXn7nQ6n7kB8zRCOHjCoXS73UxNTTE2NsbevXsxm83Ex8djsVg4ceIEb7zxBunp6Vy5coXp6Wn27t1LQUGBDCGbTCa5Y9OgYS0gVISjF+Dh4WFSU1MZGRnhz/7sz/jJT35CdnY2v/d7v8dv/uZv0tvby6VLl7h48SImk4n8/HxpY4xGo0w9i7SBcHiEbVuNBd/n82E2myPm35UrVzhx4gTHjx+nsLCQP/7jP+a73/0uJpOJixcvEgwGSUxMJD4+XkaRhROiPseV2nfh7KSmppKUlERhYSEHDhwgMTGRc+fOoSgKW7du5c6dO/zjP/4jH330ES6Xi8OHD/P9738fh8PB+fPn+eyzz/D7/WzYsEGer9VqZXFxMSLtpd7Uut3uVbEhIhovsgM+n48bN27Q1NTEn/7pn3Lnzh1KSkr4tV/7NQ4cOIDJZGJhYYFAILDiyNJaQhd6zGxK9U4zGAzS3d1NU1MTra2tDA0NsWPHDvbt20dJSQl+v1/2D+ns7OSTTz7h+vXrxMTEUFZWxuHDhykpKZHHXo00jVoCfDnY7XaZb5ydnaWgoIB9+/axc+dOUlJSgHBed2Zmhv7+fj777DMaGhooLCzkzTffpLy8nOTk5IhBIXKrjyt0+mWCOhQpom+BQEAaQ7/fz5tvvsnWrVtxOp189NFH7Nq1i+HhYf72b/+Wmpoavv3tb5ORkSF5Q3q9noWFBWw22xP+dRq+6LifEwJh2zk6Osrbb7/NqVOnyMnJoa6ujrKyMrKzs8nIyKC7u5vOzk7OnTvH6OgolZWVvPbaaxQWFuLz+SLS4z6fj2AwKCN+q6GpIyLAAm1tbbS2tnL9+nX6+vp4/fXXycvLo6amRla0nTlzhtbWVtrb26murqa6upq9e/eSlpYWcV1g5eKDwWBQ8vfUnJyf/vSn/If/8B94/fXX+Xf/7t+xsLDAz3/+c0KhEDt27KCkpASDwcDi4iIXL17kww8/pK+vj7KyMl5//XUqKyuxWCwRm0mR7he2fjU2y9HHmZ+f5+LFixw7doyWlhb27NnDnj17qKysJDk5+ZmO5j52ZwTCF/PmzZs0NDTQ0tKCx+OhoKCALVu28NJLL2G326UKJoSdDKPRiMvlorGxkfPnz9PT00N2djY7duygqKiInJyciHzqrwrBfFYTurxeL6Ojo0xOTvLf//t/Z2xsjMTERHbu3MnOnTspLi7GaDRKfojX68VgMOB2u+no6OD8+fN0d3fj9/vZtWsXW7ZsoaKigqSkJMkcF961hpUh2tkVxL7Z2VnOnTvH0NAQdrsdr9dLcnIyi4uLTE5OkpGRQVZWFvn5+VRVVWE2m6UkvCDfaZERDY8bHo9HpjUgPIanpqYYGhpiamqKn/zkJ1itVkpLSzl8+DBbt25dsgGbmZmht7eX5uZm6uvrmZ2d5cCBAxw5coSUlBTJJQEiiPSCHLlSeL1eBgYGqK+vp6GhgWAwSGlpKRs3bowopxV2UlEUBgYGOHr0KJcuXSI1NZUtW7awdetWNm3aJAmZq5XqUNuI27dv8+6779LQ0IDL5eLP//zP2bt3L4ODg9y4cYOcnBwKCwuBcNpIp9PhcDiYm5vjxo0bnDp1it7eXsrLy3nllVcoLCwkOTkZvV6P3++PKFxYDagj883NzRw/fpyenh5SU1MpLCzk+eefp7i4OKKaSRRMhEKhZ2qdeezOyPDwMD09PVy5coW+vj6MRiPl5eXs3buX4uJi4N4Fv379Oh999BGZmZm8+uqrpKSkEAwGZdfFtrY2JicnyczMZNeuXVRVVUmS60og0jKiUqenp4fz58/T3t6Oz+cjNzeXl19+maqqKhnqjI50qD1kj8dDfX09p0+fZnBwkLS0NIqLi6murqa8vFw6Pdru+2EI8ijV506nM6K6Shif6elpenp6uHHjBh0dHaSnpzM/P098fDw1NTUUFhaSnZ0NhFOHcXFx8n9Ac0g0rCn8fj/Dw8O0t7fT2NjIzZs32bBhA3v27GH37t1ywyaIoUNDQ5SWlsrqjvHxcdrb22ltbeXWrVvY7XbeeOMNioqK2Lx5M2azedV26wJzc3O0t7fT1NTEzZs3CQaDVFVVUVdXF1GdJiBs5fz8vOTAnDt3jpaWFhISEti7dy87d+4kNzd3VVLYwjkQ59rU1MT/+B//A0VR+N73vseOHTtQFCVi3ns8HkKh0BKnb35+np6eHlpbW+np6WF2dpaqqiq2bdvGtm3bliz8q0HAhXC06dy5c/T09ACwadMmdu3aRUVFhYx8LS4uotPp5Dms9n1eCzzUGVF70gJutxuv14vNZsPhcMgFVc0Mn52d5ebNm3z88cfMzc0RCoXIz89n165dlJeXY7Val1yw9vZ23nvvPTo7OykqKqKuro49e/ag0+nweDzcunWLCxcu0NbWRjAYJD09nYMHD7J169YI71/k2OLj45f8HlEPbrFYInYHgUCAgYEBzp8/z5UrV/B6vaSkpHDkyBHS0tLIzMyUpXSiH8pyA03szgX/4OLFi1y5coXu7m5SUlLYu3cvNTU1ZGVlLdmViJCtuC7PBtFVXct+Nwx6n3eqWDnLvl+35HjLOSNKxPFDqlCzz+cjFApJI+bxeKSGjd1ux+VyYTabSUxMlONPlB8CMk0ojudyuR6aBnzYhF+uWiIagkQdXXEFRETrhBOsjgBpeLJ42F4uuqT2fuNFLJSnTp3i9u3brFu3jtLSUg4dOkRWVhZmszliYe3s7OTkyZMAbN++nZqaGqxWK8FgkJ6eHpqamujq6uLGjRtUVFSwd+9eysrKSE1NlWNK2L5gMChLVNWcNjEuhZ1zu92YTCYURcFut3Pjxg1Onz7N5OQkbrebgoIC9u7dS0VFhYxsR1dRRiMYDDIyMkJLSwuXL19maGiItLQ0qZy8cePGiGstrl8gEGBxcRGbzSav8cLCAiaTSc5Z4QyINcxut3PixAn+4R/+ga9+9at85zvfQVEUEhMT5bkuLCwQGxtLMBiUsgzR92xmZkamo86fP8/69evZuXMne/bsITc3V0ZY1fZdXGNBPhW4n8PidDqZnZ3ll7/8JVevXmVoaIj8/Hyef/55tm/fHrHefVHwUAKrmECiDEuIfImwtpgkwjjqdDq6urr49NNPOXPmDC6Xi5ycHHbv3s2ePXsoKCiIMPBiAdDpdCQnJ5OamorZbGZiYoK2tjamp6dxu92kpqayYcMGcnNzSUxMxG63c+vWLe7cuYPdbpeTCiAmJgaz2czi4qI02OJ7hBMhCF1Go5HBwUEaGho4efIkbW1tGI1G9u/fz5tvvkl6ejqJiYnSCIgyXTULHu4tSur/FUUhPz+f9PR0Wf4rDITT6ZTMbOG4CKdP3TH26fdu1cb4wed679WQ6n9d1OvitaDqPer3RX6HcjeEKerr1QbAYDAQCASIj4/HarUyPDwslVmTkpIiDJcQFFI7m4+y2D/s/qjnj1iUBDdFPC9Ib4uLi9IIer1eent7uXXrFnFxccTGxkaUP66WjoGGxwt1CljcN7fbLZ9bWFigpaWFo0ePcvnyZXw+H+Xl5dTV1bFv3z4SExPlGFU7tbOzs8zPz9PS0kJ/fz83b97E5/ORmZlJZmYmBQUFZGdnY7PZuHnzJpcuXWJ2dlY6E1arFb1ej8PhkGkFERkW5G1h50SViLDvvb29nDx5koaGBkZHR8nPz6euro69e/eybt06gEeeP4LImpOTQ3p6OgaDAbvdzuDgINevX2d+fl522/X7/djtdqxWK4qiyDVIzFfxO5xOJ263G6vVSiAQoL+/n9nZWYxGI06nk97eXkKhEKOjo3R2dhIKhcjOzo44pqg2gkgtKp1Oh9VqJS0tjezsbPLy8pienubChQt0d3cDyPMF5LUUshHqdUOsP4FAQOrJKIrC/Pw858+f58MPP+TGjRskJCSwZ88e6urqKC0txWazRWhXfVHwSNU0aq0MYUTVg0A8PzY2xqlTpzh69CiDg4MkJCSwc+dOqqqqqKmpISUlRS4Q6goIMdiNRiOZmZmsX78eCKcxPvroI2ZmZqSzIyZabm4u69evx+PxcPr0aXp7e8nIyCAuLg6dTofJZMJkMkmHRHjzasbzxMQE/f39fPjhh3zwwQfMzc2xe/duvvGNb1BTU0NSUlKE4JkaYmFROw1iYVIzqw0GA2lpaeTl5ZGYmIjT6WRkZISBgQFu3rxJKBQiMTGRuLg4OSjFpA8EAs9AdEQ4DyqdhGXepVvyKDIestRR0UX9u/fZyEfI3YZaqE4s6kajkbGxMS5evMilS5e4du0aw8PDckcSFxcnCcVC8Ejsph6l2uDzOovq8afe5QknX6/XMzg4yIULF7h8+TIjIyNkZWXJlKUwQHq9PqI6S8PTCTVJdHFxUWpT+P1+Ojs7OX78OK2trYyMjJCens7evXs5ePAgRUVF0gEV40Q9Hk0mEzabjZSUFHw+HwMDAwwNDUnnIjExkXXr1pGeni7TJa2trXR0dMjxLgQmBUT0TUSNxfuEPZuYmOCTTz7hF7/4BQMDA5JHt23bNioqKiSBUozNR7VdIuKXlZVFQUEBiYmJOBwOhoaGGBgYYHR0FAiLuYnNm4jaiPkE4SiDsP06nY7Z2VlOnDhBc3MzLpeLrKwsWYprtVqZnp7m4sWLDAwMkJ+fT1JSkjxn9XqnjiQJO28ymUhOTpbcxVAoxPT0NL29vQwMDOD3+7HZbBFpePV5i3sq7JSogGlqauLYsWO0tbUxNzdHQUEBNTU17N+/nw0bNkhdJDH3n/7N6qPjkZwRdQmq2MEJz9nlcjE/P8/Vq1f5+OOPOX/+PAC1tbW88MIL7N69OyIlIWrS1eFwdbMzg8GAzWZj48aNbNmyhdTUVNng6OrVqwSDQbKzs0lPTyczM5OMjAxsNpvMXXZ1daEoitT7UHujglHtdrvp6uriypUr/Ou//it2u52SkhJeeeUVDh06RE5OjgyHq8Pkgi8SHW5dLgwvBq0gQcXExJCTk0NJSQkpKSkyjXXnzh0WFhbkIqjWJlktgtnjRaRTcT8sffVhzsgjHumusRDGE+6J4o2Pj3Pz5k1+/vOfc/78eYxGIyaTia6uLq5du8bU1BSKosjIgxDSE+Xjj2JMH2YMBEHxfqWKIqQbCoVwOBy0tLRw/Phxrl69yuLiIps2bWLz5s3Ex8dHRCCBZ2BsaFDfc3HfZmZmOHfunCQjxsXFsWPHDl566SWqq6tlB2m73S7tUHSax2w2k5KSQm5urtzkzc7O0t3dTW9vr0xTZ2VlkZ6eLiO0k5OTtLS0MDw8DEB8fHzEhlJty4QWlMvl4tq1a7z//vucOHECr9fLjh07eOGFFzhw4AAZGRkymivO8VE3UyIF7/V6MRqNWCwWcnJyyMjIYN26dbjdbnp6emhvb8flckmhQogsBYZwGknMp+7ubk6dOsW5c+dwOBzk5+dTXFxMWloaGzZsYMOGDVitVvr6+picnGTHjh2kpaXJzbGwA9EVR+rHYmOQk5PDc889R1paGuPj43R3dzMyMsLMzAxGo1FWiKrvn9rJc7lckgB84sQJ+vv7ycvL44UXXqCuro7i4mJiYmKkfRKO0hfJEYFHJLCKyEX0BQgEArS0tNDW1kZzczMej4eKigr27dtHYWFhxMIanY8Xn/d6vTKvuFwuPBAI0NHRwcWLF+nt7cXn85GTk0NNTQ3l5eUkJCRIVb13332X3t5eEhIS2LZtG1VVVWzfvj1CCEhEb9rb23E6ndhsNrZt2xYRYhT9ZSwWyxJ9/1+l9l3I2YvwYiAQoKenh97eXlpbWxkeHiYuLo7nn3+enTt3YrPZluQWNTwYwlEU6brOzk45Nu12O5s2beKll14iLS2NK1eucOnSJWZmZoiLi2PPnj3U1taSnJwsQ7XimA9b8B82FtQ5YRH6VUc2AoEABoOB27dv88knn9DU1ITFYqGsrIy8vLwIJWJ1FG41yjI1rByPwhlRV2g1Njby6aefMj4+TkpKCmVlZWzcuJHCwkIpFfAo3ykWfhGut9vt9PX10dTURE9PD4qikJGRwaFDh1i3bp2MNnd1dXH27Fm6u7txuVzk5+ezfft2qqqqZPRN7VR0dXXR2trK5cuXWVhYYMuWLezZs4eSkhLi4+OXbMSE4/R504diLgjxNLFWDA4OcvXqVerr6xkdHSUnJ4d9+/ZRWVlJamrqkvl369YtGhoa6OzsZH5+nk2bNrFx40Z27twprwHA5OQk7e3t/M3f/A0xMTH85V/+JQUFBRFRFkVRJPfjfqXX0XN7bGyMjo4O2traGBgYIC0tjZKSEqqrq8nPz5frAzbxAAAgAElEQVTXRdAeFhYWOH/+PPX19TgcDnJycti6dSvl5eWSfyIgdEvUcvVfpDXikQis4sera8o7Ozvp6OigubkZu91OSkoKe/bsidDfgHvqmPfz5NSkLLhHUhLNgcQFF0Ivp06d4vr167ITY3l5OWVlZRgMBqanp+nu7ubYsWP09fWRl5fH1q1bKSkpITU1le7ubs6dO8fY2Bjp6els2LCBr3/96zLfKLxXcR5er3eJF/ooZDT1JVW/Rx1ZEYSmGzdu0N3dTXt7O7Ozs6xbt46amhqqqqoiyp2fTQQhpDwsaHJfRDJKHg19fX00NDRw7do17Ha7zLdWV1dH6L10dXVRX19Pa2srgUCAzMxMamtr2bFjhySHid3ag/AwZ0TtNAgDp84b9/f309XVRVNTE8PDwyQlJVFZWUltbe19yXvi3DQC65PHozgjTqeTvr4+6uvraWlpIRQKUVFRwbZt2ygtLZW9uSBsD0Ua4H4QKcTlFsnR0VFaWlpobm5mYGAAm81GdXU1VVVVrFu3TpL6L1y4wPHjx6Wo5Pr166mpqWH79u2YzWZ6enro6uri8uXLzM7OkpCQwK5du6itrZWK2LD8gigiIo+yaYse18LREtcOwun6W7du0dTURFtbGy6Xi8LCQkpLS6mtrSU2NpaFhQUaGxs5e/YsExMTbNy4UToB6enpsspEaK18/PHHXLlyhZGREXbv3s33vvc9SYIV10j925Yjootzd7vd+Hy+iEKOtrY2rl27Rnt7u2yqum3bNvbt28f69esZGRmhq6uLY8eOSWVaQTQWVabiWPcT+fzSOSNqB0T8+Pb2dj7++GMmJiYwGo2UlJSwZ88eWZ+tDperIRbg5SbbcuI/6ovv9/vx+XzMzMxw7do1Ll68SFdXF7m5uezZs4ft27eTnJwsc4EnT57k1KlTmM1m8vPzMZvN9PX1sbCwQGlpKfv27aOgoCCi4kZEZoQDIr5XnZtTd9UUpCT1+UZDPbjFewQRShiUQCDA9evXOXbsGJ2dnWRlZXHo0CG5W3masTx9NXjv/whnZGm1jS4E6CLfp6awqk2tPIz4DBAKhcO8s7Oz9PX10djYSG9vL7GxseTl5bF//35KS0tlOFTkcgGp0lpfX8+lS5dQFIXt27ezc+dOioqKJFHsQXjUKJmaFxUKhRgZGeH27du0tbXR09OD3++npqaGnTt3kpGRIUP1wiEW43A1+3ZoWDkeNj76+/vp7++nsbGRvr4+0tPT5c5epJLv53ioU3zCLkaPN7G4RkdS+/r66O/v5/Tp01K2fM+ePZILJ4558uRJWltbGRgYICMjg5KSEoxGozzvQCAg7WV5ebk8r2gbLs5DpCXg0UrjRTREcKaiXxO21mg04vV6uXz5MsePH2dkZIS4uDgZSZ6YmODKlSssLCxQXV3N4cOHKSgokNdEOHA6nY6JiQn+5m/+ht7eXv7oj/6I6upq6awI+XiIFNVUO0kCwoZHO4QiWuX3+2lubqa9vZ2rV6+i1+spKysjNzeX2dlZ+vv7pfDbwYMHKSkpkbbpfhGm5daoLwoe6oyovT/BVP7nf/5nLl++zI4dOzh8+DB5eXlYrVZZFSIGldPplLkudegvGkK5Tuwa1Td+OUlbr9dLd3c3XV1dnDlzhrGxMSoqKnjttdfYvHkzVqtVCpedPHmSjz76iOHhYerq6njttdfIy8uT5CJR0qaueBC/W90RdrkSL+FUiNflRV0mlSM6PJpMJjmIhNe7uLhITEwMoVCI48eP84tf/ILExEReeeUV9u/f/5Bb+OQQIrpIV+1cRLWv1inyneJzini/eKRyRqKbX0ccH+Q7Fh1Obg3cpr6+nsbGRgCee+459u7dy8aNG4mLi5MOsLjugrlusVjw+/04nU7a2tr47LPPZL52165dFBYWSgf7fvi8zgiEU4Xnzp2jvr6esbExOY9KS0ul8ROOuyDjATLFI46nOSNPHg9zRj744AM++eQT5ubmeP3113nhhRek3ofNZlsSOVOP0+h+NdHl3tGLfXREQkRkuru7uXDhAmNjY5SUlPDyyy9TVFQk58Dg4KBMhZ8/f57R0VGKiorYtWsXdXV1FBYWygVavVN3OByygu1+5/gwRKcbRcM60ehSQF2273A4aGho4OzZs9y+fZu5uTnMZjOVlZUcPHhQRptEGkun00VoOg0NDfGjH/2IxcVFvv3tb5OVlUUgEKC4uBiLxYLBYJDn9TC9DjEnRToOlnK5pqenuXr1KhcvXuTatWu4XC7i4uKw2Wz82q/9Gps2bZIpJFHBE13+q5YseHYqLT8fHpkzInbwY2Nj/MM//AO9vb38+Mc/Ji0tTdZoezyeCA99NYRXHnZ6ra2tnDlzhsbGRiwWC0VFRXzta1+jpKSEhYUFZmdn+f3f/302b97M97//fclIVqsBrgXUKR+RXxSDa3FxEQgbj9HRUW7cuMH8/DwlJSWUlZVFRFZmZmZITk5eVXJrdAhS3UlTnQ6I3o0/3BkJQTAIip5QCPyBAEajmWAIgjrQAyF/AEWvAxSCIbDPO0hIisPpDmEw6QgEwGxc6ox4nI7wol5/gSstzUxMTFBeXs6BAwfYvHmzbF3+eaAmFo6NjREfH8+bb75JVVVVRLNGdc5WHSqPvo7iHgmCsslk4syZM7z99ttMTU1RVlbGN77xDVlBpt7FRfOrHjcEr0mtHrkanJmVRpbE+Ismk4t7KzYy0fdBbCTE3+r0mHiP6EO0GlCPC/F9/f39/OAHP2Dbtm189atfZdOmTZhMJsxm85pGthYWFrh9+zYXLlzg9OnT2O126urqOHLkCLGxsaSlpeF2u7l165bsnl5dXc2f/umfPvFU8XLpEVF16Ha7uXDhAn6/n8TERLmoi+ijqPiMvs5Op5PTp0/z2Wef0dTUBEBpaSlHjhxh//79kswOK2/WJ2gIQk+lr69PCi+mpqZSVla2ouN/kfBIcR5hUNQ6HaJ0VvQ/UPc8UC+8jxuVlZVs2LCBrVu3yvLN+fl5/uAP/oB169bJypqEhARsNltEJcJaGnu10VPvdkRJWFtbm+ylUlRUxNzcHOfOnaO8vJzq6mqee+454uLipGMiiJor/Q1qcR4xgc1ms4wYqMOU6lLmQCCAXpCxUKVU1I4IgKIwOTpCWta6sJEAQnfXn6lZO2mJ8ThmZ4iLT0DR6zGazQQBs+Uu61wJHykQgsUFJ/GxMegUuNLYxL+99wvO1V+gZucOvvOd77Br1y5ZuqdepB4GIYSXkJDAyy+/zJYtW7h06RIdHR28/fbbNDU1cfDgQSorK4mNjV2i+Op0OgFkqFdNgIZw5UN7ezvvv/8+bW1trF+/nt/5nd+htrZW6p2osZY7HhGKFt2OARnhVEf+Hhcednz1LjwuLk7uVtV9VgQHS5Af1Z9T94BSj+HV7g11P6drcHBQ9pMxGAz4fD7m5uaWFWR8XLDZbJSXl0sexdmzZ2lsbOTEiRP87u/+LrW1taSnp1NcXMz8/Dx9fX1kZmY+FVLi6ki5uhJFRGS++tWv4nK5pHaKgFpmAe7de71eT0xMDLW1taSmpvL8888zPT2NXq8nLi5ObhxWq8eLWp8qOzubxMREgsFghG6QhjA+l7cgqhWEMyJq5ufm5viXf/kXCgsLefHFF9e0CZzP5yMtLY1Dhw5RUlJCfn6+9GrFbkX8i2Z9L1eS+7gQHVoTeis3b97k8uXLTExMSNZ7eXk5c3NzpKenMzQ0JOvk6+rqIjg0q+Hsqcvv1AuDmrUtXlOnDOTveuDRg3gdDtKysgBob2vjn97+F27dGSQmNo7SkmL+rz/835mZmeH2nUGKSsowm400NFzhSnM7X3v9NXI2pOCwB4ix6omPj6H7Wg9//1//X7qudbJ+/Xr+8A//kG2V29myZQuKouB0OuXCql6cHvT71QuxXq+nuLiYzMxMNm/ezMWLF6U65IEDB3jrrbekhLwQAVQb7eg26FevXuXkyZOcPn0avV7PSy+9xIsvvkhOTk5E6BXujcm1NFLLlS8Cy97rJwlRiQaR56Yui4+eD9GNNEXFBrBm+Xaj0Uh8fLz8vs7OTs6ePctrr71Gdnb2Yz8P4SibzWbi4uJk+rKhoYH29vYl3x8TE4PFYsFsNq+4CelqQV3+LsaAes6qIxlwT4ZBRCNhKecjJSVF8vHsdjsOhwODwUBsbKyMXovvXgnUuiI6nW5V+ql9UfG5Z4JaL0HcqLm5Of7xH/9R1p2vZlfIh0F9/KysLI4cOSIXzlAoxOLiIh6PR+5+1dU6a2lsBfEIiGjKduHCBTo6OqiurubVV1+NIDDt37+f1tZWTpw4waeffsqGDRsoLS2NkG9eKaIli6empujt7cVisVBVVSVfi44yqCf2UtH2ewkcU0wMEOR//fRn/OzdX6A3WjGZLfiD4HZ5+L3f+13izFYqq2tITs2kpb2d/+cv/iNTM/O89e3v4HBAXLyesZFZPv7g3zh+7Bj6kJ9vvP4G+w/tp6isHHTh8xI7pM8T/laXlgsjFhMTQ1JSkuwJcuHCBT744AN++ctf0t7ezsGDB3nppZfIzs6W99TlcuFyuSQp8c6dOxw7doyLFy8yPz/P5s2bOXLkCHv27JHfpVZkfVAJ4eOEaEkupPKjndDo0vZoPOz1lf4el8tFbGysvKfqVLDdbl+WgC7OXxCAhSBedGXcWtin5ORkqaMhxMl+9rOfsX37dtlA7nFCcNE8Ho9UJc3Ozuab3/wmdXV1+P1+0tPTJelydnYWu92O2+1+aIptLaHm9Knttrjn6jVJREnU0WeR9lS/X4yp+Pj4ZSNV0ZWevwqi+T8CoiDjYXL5XyZ87tVMXQ8udhnJyckYDAZSUlJkiH+tRFnU5D4RsRHnJYg/YoCqyV1rLRojokVi8QKkEmtWVhbV1dXYbLaIiRUIBKiqqmJwcJCenh6Gh4cpKyuLmEgrhajUENdnaGiI999/n8TERKkCCeHJoyb0ikXogUtRKAg6OHfyJP/+3/978guL+L9/+BcUlpRhMusZH5nkJ3/7n3n/3Z+TlpnFunUZnDg1e1eyPYWQTkF/92dOTc3Q3tZBSkoK3//e/0bVjrCj5HQ6MVti0Ov1Syb2oyw0go8ALNlJCV7P7t27qaqq4ujRo7z33nv867/+K11dXdTU1PDKK69gMpmwWq1YrVbGxsa4dOkSDQ0N9Pb2kpaWxne/+11efPFFYmJiJMtevetc7jyXqy57nFATq4Flz3M5PO7zi44SibHv8/m4ePEiU1NT5ObmUlBQQGpqakSkSdxbtfOh3kSthcKxcFKFPLpQEF2rRUjYYovFIh0OMdejUwUiiiP0oZ4mufHo1Lb6ueg0p5pQq7ZbYh0Q0UC455CqpRyEjVutVA0snSfRTr+GR3RGoj1RsaMTqqlWq5WYmJiIXf1aqYdG75wEaQnu7aKEIxAt2LaW5FW1gi3cE92x2WwUFxdLyWZRk65+78GDB6UzcufOHXJycjAYDKuSqokuHzOZTNIhEucB4Ykp1P8ete8EwNTwMO+88w4JCQn84Ac/oKysDE8gbEyy1qXxn/7zf8Gk6O7m04N85Stf4UbfbRouNjI1NUXh5kwAcnJy+OEPf4jZqJAYZwWfD7/PR0xcHKDI+xkMBuV9f5Qws+DeqK+DGL9i0QuFwh08jxw5wt69ezl27Bhnzpzhv/23/0ZPTw/79++npKSE3t5e3nvvPbq6usjOzubFF1/k5ZdfZsOGDej1ejwej6wUgKVpBIgUb1sLZ1ldlaPOqwtj+bDd8UoJqg/7vBhngsMibMrU1BSXL1/m7/7u7ygqKmL37t1s376drKwsEhISSE1NlU3hxDwStkv83rVYDER1oThvp9NJUlISsbGxa0JiFdEQwb1Qf5+IHovzFE6L2Kg9DWm65aJXau4aELHJFJEP8brFYlkydtSpULVmlFqQTESuV7pGiPksjqtOxWqihZH4XARWWNoIzmAw4HA4sNvtzM/Pr3k3UbFgipyfxWKRvRVsNhvz8/ORKYW7g+Fh4eXVgvC41UZVUcKS9GNjY8TExBAfH4/D4WBqaorx8XHZ60BoYzz33HNkZmYyMzPD1NQUmZmZcsFYKcSEm52dZXBwkK6uLnkte3t78fv9bN68WV5btcaKut3d0h8eBIK0tlzhl6dOcqDuxXAHZr2e+UUHJkscs3NO0uJMfOfXv8349Bxzc3OkpoebTA0OD7EhJxOXB6xmSEw0ok9IIRQA/F4wKBhUmhuCzCgIap8H6gVLhE/FGBJ9RETFWHp6Oq+++iobN25kcHCQd999l7GxMcxmM9PT05hMJl555RWp+JiWlgbcW5TgXnRROJTRRn+tI3YConxfVACNjo6uuGvxSp0ZEU0MBAJYLBa8Xi8Wi4W5uTkZ+Whvb+f69eskJCQQHx8vu6hWV1eTm5tLZmYmiYmJkkD6qOe+GhDkfghvNCYnJwHWLA0iOAqiAaSa+xXNoYOws+RwOGS14dMGdTHFcg7TcnxF4YiJqLR4Xcy96GorYbOX0z75vFjuGq4FMfxZxK/EGRHGW4S39Ho9iYmJESJR0TXzjwtioReLJdwjDanLwsRgU5Pg1gLiGkTnOuPi4mQnWUVRuHHjBu+88w6tra2kpqbidruZn5/nhRdeIDMzE4/HQ0xMDKmpqRgMhgiJ+5WeH8C1a9d47733uHbtGtevX0en0zE6Osrzzz+PxWKRaqBi8gaDQYKKHpT7TapwGUzH1WssLCyyYcMGnE4nsbYEkhLjcPkhKTEGgj4KSospwAQK2B0uAkEPBr2JhYUAaal6PD4IuEPYrDoMesIlNn4/oMPn92M03VswhYDSo447NW9DONdCZ0AoKwoCohhPQm14aGiIDRs20NbWxtDQEFVVVVRWVpKfny9TluK+qw1g9A51OYio42qGiu/3PaJsX1SmhEIhyZPp7Ox84Ocftrt7mNP/KM6KcA7j4uIYHx/HYDCQmZnJwMAAPp8Pu90OhEuzFUWhp6dHllG+/PLLBINBKSKnLvtcC85IMBhkZmYGCEcXbTYbRqMRj8ezJjZIXaYfvQiLaJ3ZbJbnIsb+WqYIH4QlhPlQaIkjJZx7Ef1QOxXiGGrHJTpV7/f7I6QegsHgqt2baNVl8f1rnYZ9FvArcUaE8RbGWRDgRD4SkJN+pXiYBykGjXoHJwy9UO1Tn7OA2Jk+bogQPxDBuVAUherqaiYnJ2Xp6G/91m/R3d0tz0un05GTk4PD4eDs2bMcOXJEEtJWa5ESBMa0tDTq6uqkI2SxWDh8+DCVlZVSHh3uaU8YDAYCgJ9wZCQEhEKgI3SXv6oD9Pj9YHd4MJnMd++HH73JQCDoJ4gBFD+g4PMEUfQKAZ2TqelhEhNTCHhD6AjrjOgN4W69gZCHUNCFwWAB9Bh1ypLf83kgjHL05wQJTu3wqd+jKAo5OTlkZWXJ/kei0aFapyN6jD3qmFurijR1F2Bx33U6HdPT01y+fJnr168/9nN4EIR9ERFF0cSwvb1d8lrMZjNJSUmsX79eNhbMzc0lOTmZ0tJSEhMTI9KywglZzYXgfnbK7/eTlJQUUd2xsLAg5/Hj3iEvZyfUY1DtFIuW9qK8/2lQ+Y2+Psvds/ttepeLmiz3ejR/YzXHxXLX72lJgT1tePricF8wqAed2jmzWCwkJCRIaeVQKERhYSGbNm0iJiYGn8+H0+nEYDBw9uxZ9Ho969atk22uBcF1pQuW2KVv2bKF7OxsjEajJNW++eabOJ3OCKa5OroUCgZAUX2/LgTBu8IgBCEEjoVFNqzLIhQMd9WNi48hALjdLmJMsUAQj8eNyZAEeoiPs5CQGIvfG3Z0g/gJ4YeABYMeFAV0igKhIKFQEJ3uye4shPEW10V9P54W8t+DoM6dq8dqWVkZv/mbvym7uz4pqCvfRLjd5XLJckxFUYiPjyczM5Pc3Fxyc3NZt24dKSkpxMTESHVj9aLwOBaCp6nyRIOGZxGaM/KYod79iHCiEMxKTk6moqKCK1eucPr0aSYmJigqKiImJoZAIMDc3Bz19fW0t7dTVVVFeXm5lI9fLdEctWGOjY2ltrYWg8EgowLqyEA06TcQCDsjy5r2u0+mpqcxOz/H8PCw5HK4PB6S4234/W5Mhrv5XwXsCy4CiuPugrOIy+lAj40QYQXXu2Ku4sQJBoLon4IopwiDR+90n4Xdj0jRwL0oYzAYpLCwkPz8/AiOxZOACHOrtVvcbjcLCwtyHogml+qolMBykQFtZ6pBw9MHzRl5zFCzuEU+XsBsNrN3717m5ua4du0a58+fp6Ojg8TERKmR0NHRQWpqKl//+telk/I4dBJcLpdUBjxw4ICUW1anmMR3i+9XFOXBpb3At771Lf7Xuz/n8uXLXLhwgT37DmC9q7IaCIQI6ENcv34dRZdIrC2OlMwYrFYrttgYsrISgCA6dOiNEPBBQAlh0CmAgt7w9EQe1OWi4vGzkg9WVyMAUib9aRG9gkinPjY29nM3kIzmD2jQoOHpguaMPGZEl6BFh3NtNhuHDh2irKyM8fFxOjo6uHr1Kunp6eTm5vLWW2+RmppKbm6u7L4pIgyismAlEARgq9UaocsiNDHU/VeitVlkiP9+B9dB+oZsvve97/HDH/0Ff/mXf8l/SUpjc0kRTreXhFgr1zuvcO5cPRkZGzn4/PPEWW3MzswzOzvN3MwiOkVHjMWCLgQGAwRDIUI6lo/GPAHcr136s7TgRZ+rUK8VXWOfJKLLrYWTJ5wKQbaMblmhxv36jKy18KEGDRruD80ZecxYbpFSdwYOBAJkZmaSmZmJz+cjKyuLvr4+1q9fT05OjmzQBveqhABZYbBSCJE4dXt6wcAXFSTCiKv7PKh/m0KUcyAehGBxbo6vv/E6M/YFPjz6MT/84Q9Jz8rEbIkhNs6MLUZPQf4mdu3aiV6v59Pjn/HLU2e4eaOL//if/oI/+T9/h/T0dOKs4RJug86I+NZAMID+CUcfoln6T3rxXgnUjqcgNj8t5Z33I/Qu95xwXNS9a5aDOmqpQYOGJ4unw9J8gRHdhA6WarVAuHOv1WqVDa2EPsDCwgIWi0U2/BPvXc2yQK/XCyD5Ieo8+/2MtdAZ0fGA/jQ6iE0OV+L8H3/8x5SUl/Ff//7/4+bNmySnpDE9M86R116h7oUXSU5MY2p6hvHxSUpKSsjKzMfvc2PUm9Dr1MNUIcS93fKT5ow8K6mY+0HNZ4qO8AjBqCcJtXDhchEodVNOtdP8oPsinGnNEdGg4emB5oysEdRKf2qoNQ/Ea8IRWVxclKq2IkIhFg0hxrXSnWsgEIggqaoF2oQGgbqGf9mUBKAIz0Q8ofJQFubmsCUl88KLL/L8oRfRGxT8obBEidfvxGIw4nQ5SUlJ4bvf+Q3e/OZbWC13O0D7gpiMdwXJAkF0IR/Gu1yRcNfgp8MZWC7kv1YqxCuBWu9AnKtaI+hJn3+0gF10ykUdHVTrYywnAa8u739aIj4aNGgI43PNSHVuVoSkxc5J9KQBpFqlx+N57CQ4dS28+u/oluJPGg+KMADS6VBDLceuljIWzsNqN8qDSDE4ESF5kOaF9D90dx/pxIN7C7MtMVH+bTAohLinlWYyWAgSxGK1ECKEHoVYy73IjMV4z9kw6RWCmAneZak8nD67dliOe/CkF/JHwXKEzietLfEgPCjisdxr6udWW1tEjftxTywWC7Ozs1JMLD4+Hp/PJ0v6HzcexJeJFqQTgoGiA7K6VYAGDY8bK5qZQn3V7XYTDAZxOp1SLArWZvcRrR/g9XplDxBtIj1e6AgPIEX1OCI6ov47CkrEX8sNw7CcvC6kfuxXfSb8jKbuoOFpwP10RtRN8UKhEPPz81JNeS2g7lYrVH3FJk29mYR7DpVoLvespyA1PFtYFW9BKPapqy1EdORxQ4ggBQKBJdEFp9P52L//yw7pLNxvk7fM8zqAu2ka4VCEGShBQAkfU3fXSIaUu05OgBBBxJBVZ4U0aHiaIaKNos+OwWAgPj5+VVrUPwzRTpK6GgmQjor4W8ijP00dezV8ObBi1zcYDMr21FLU6m7L7LWAKEMVjsji4iLz8/MEg8E1231oWCkUZIGwtJ1+ZCREKLrefU9IfkaDhqcbguclxOOMRqNU7RXE8ccJkXpRdy+Heyl3dT8Wcb7q1zVoWCus2KIL4t7U1BQejwe4R4Jci864oi+OQGxsLDabTQsxPmGEov4tB51oY7Pse+46H6Gox1HfoUHD0wx1GT8gxQRnZmYee1QEkM7Gcp3X1fY5WnZftJvQoGGtsOIVW4Qe4+LiZHM8McmEc/K4IRwPr9fLjRs3GBgYwOPxrNn3a3gcCCDdDRkZuWdQBYVVg4anGUKrRej5hEIhkpOTcbvda9Y5fDmyqnA+Zmdnpb6McEBEFEWLjGhYS6wKZ8RisfDWW2+xfft2+RhYk8kmSKoOh4MPPviAX/ziF+Tn5/Pbv/3bFBQUaA7JWkFF4ljOhEVwPB7Jxj08qhYEtKy2hqcd6s1SeXk53/rWt8jKylqT7xaOiLpyZ25ujoGBAUZGRoiNjaWoqIj09HQURcHv98vCBC26rGEtsWJnJBAIYLFY+O3f/u0IwurMzIwU6XqcmJycpLGxkebmZtrb23G73RQXF5Oenv7Em3x9uSF4IErUc8u/c+lrqqGpUx/vQUfSoOHpgl6vl5UsiqJQWlpKUVERer1+TQis0arAc3NztLa2cvr0aVpbW3n99dfJzMyUzojQFFpOVl+DhseJR3JGDAaDzCcGAgEWFxdxOBycOHGCV199lUAgsGRSJScnR5SHqaWmBbxeryRzwdLGb+qKHFGuKx7Pzs5y69YtLl26RHNzM3a7nf379/Pqq6+Sm5uL3+/H5XLx6aefMj8/z/z8fIRzov5NGlaAZatlHuKAqD6jj/rrXnmwJerjRllKrD62dvc0PEmoWymIShlFUXC73ej1esbGxpienmZiYl5GLt4AACAASURBVEJGQ0TKRGgzqXvtLAeh3yRslviM2lkQFTAmkykiEiOi0y6Xi66uLk6cOEFbWxuJiYm8/PLLfOUrX5Eii4FAgObmZsbGxti4cePjuWAaNNwHD3VGxID2+XyYTCbWrVtHRUUFAwMDfPjhh9y8eZPt27ezY8cOKdK1uLiIXq+PEDwTk9Xr9aLT6TCZTJhMpgiHRHSqFbwTq9WKy+XCbDZH8FB6e3u5fPkynZ2dDA8Ps2vXLnbv3k1eXp6MxvT19dHa2srRo0fR6XSUlZXJPi8ejweTyYTb7V6T8uMvLx4ev7hnfpWoJwzLPtacDw1PK9TOhKIomM1mysvL6e7u5n/+z//Jiy++yJYtW6RSrF6vl1pMok+V2sEQmyX1cXU6XYR+khB6FL2khHy+0WjEZDKxuLjI8PAw9fX1XLhwAZ/Px+7du9mzZw85OTkkJyfjcDjo7u6mqamJxsZG4uPjyc3N1TZqGtYUutAjspTcbrcc8OPj45w5c4bu7m46OjrIy8ujsrKS7du3k5eXJxd4n88n25GrIx5qCWqIlGwWr4soiXCCAEZGRmhsbKStrY25uTkMBgOHDx+moKCATZs2ATA8PExzczP19fVcvXqVyspKiouLOXToEOvWrcPn80UIEWnQoEHDrwq1AxEtPb+4uEhHRwdnzpyhpaWF9PR0XnzxRWpra0lOTsbv92M0GiMk6tUOgHBGou2leE08J0qH1aW7drudiYkJ2traaGlp4fbt22zcuJEXXniBqqoq4uLiCAQCjIyM0NLSwuXLl5mamiIzM5Nt27axfft2NmzYoMnma1gzPLIzEgwG8Xg80gsPhUIMDQ1x4sQJbt26xdjYGGlpadTW1rJz507S0tLkZ5ebTBAZRhTvW24yjo+P09HRQVtbG/39/RiNRp577jlqamrYsmULgUCAqakp2traOHPmDLdv3yY7O5uKigr27t3Lhg0bpNqgz+fDbDZrXr8GDRpWDHVqOdrOBQIB3G43ExMTtLe3c/nyZUZGRli3bh379u2jsrKSpKSkiFS1OkJyPxulro4R1YzBYFDa0omJCS5evEhbWxtDQ0PYbDaqqqqoq6sjIyMDh8PBxMQEfr+fjz/+mP7+fvx+P1VVVezfv5+NGzdq6tUa1hwPdUacTid6vT4iTSL+FvLC3d3dXLhwgc7OTvx+P1u2bGH37t2UlJRIMbJgMBghMywmjrqfjDpFA+E8Z3d3t4yGKIpCUVER27Zto6ioiLS0NCYmJhgdHeXKlSs0Nzfj9XrZtm0b+/fvp6ioCLhXcaM+d6/Xu6RJnAYNGjR8HkRvoJaTURcyAyMjI5w8eZKGhgYSEhLYsWMHe/fuJSUlhaSkJPl5r9cro9DRxwsEAhHdvtX2c35+nra2NlpbWxkaGsLtdpOfn09tbS07duxAURQcDgddXV00NzfT3d1NMBgkLy+P6upqtm7dSnx8/LK/S4OGx42HOiPCiVBHMMQEUUc2ZmdnaWpq4sKFC4yMjJCQkEBWVhYHDx5k3bp1kq8B4ZSP0WiU0Ypo1rbf76ezs5O2tjba2toIhUKkp6dTXV1NdXU1SUlJzM7OMj4+TltbG1evXmV0dJSCggLq6uooKyvDYrFIEpnQP1HvNtRpJw0aNGhYDSy3iAuunNFolKmbixcv0tvbS3p6Ops2baKyspLCwsIlqtFqZ+N+WFhY4NatWzQ3N9PR0YHP52PLli2UlZWxY8cOzGYzXq+XgYEB2trauH79OtPT0wSDQZm22bBhA4DUPxHpH80h0bBWeOQ0zf0GZnRk4/bt27S3t9PW1sbg4CDFxcXk5+dTUVHBxo0bJalVnV8VSn+KojA1NUV7ezvNzc0MDAxgs9koLy+ntraWvLw8AoEAAwMDXLt2jYGBATo7O4mLi2Pbtm0cPHiQnJwcfD7ffUvT1OQxDRo0aFgN3M8+LiwsyOhwKBSSBP47d+7Q2dnJ6dOnsVgspKenU1hYSHFxMdnZ2Vit1mW5dOJvn8+H3W5ncnKSrq4uOjo6WFhYIDU1laKiIioqKsjLy0On0zE8PMz169e5fv06HR0duN1unn/+ed544w2MRqMsPPB4PIRCIWmjH8UR0qBhtfBQZ0Qd/RCLPBDRFdfr9eL1emWJmNfrpbW1lc7OTurr67HZbOTk5FBWVkZZWRnr16+P6BApIhaTk5McPXqUU6dOERsbS1VVFTt37iQ3N5f4+Hjm5ua4du0anZ2d9PT0MDo6yr59+9i9ezfl5eVLztftdmOxWGRoE4hoi61NNg0aNKwUDyOYqnVG1GRXsXlramri0qVLOJ1OSkpK2LVrF0VFRSQkJMjIbTAYJBgMyscTExOMjIxw9OhRJiYmUBSFiooK9u3bR35+PqFQSFbJCBJrMBhkx44dMlrt8/mw2WxLNm/R36VBw1rgkSMj98PDPt7Y2Ehrayvt7e2EQiG2bdtGbW0t+fn5WK3WCL2PgYEB/uqv/orU1FReeuklCgoKSE1Nxe1209/fT1NTEy0tLbjdbsrLy2XaRv6YB9Tqa9CgQcPTiIWFBW7evElDQwOXLl3C6/Wyb98+Dh8+zKZNmzAYDPj9fnw+n+S4nTt3jg8++ICpqSmqq6s5cOAAW7Zskamgnp4e+vv7+fDDD4mPjycvL4+tW7dSUVFBeno6sLSAQIOGJ4nH7oyIJnptbW3U19fT09NDUlIS+/btY8eOHeTl5UVwSBoaGkhPTycvLw+j0cjg4CANDQ2cP38eh8PB5s2bqampYevWrWRkZCxp9qQ5Ixo0aHiWEAwGcTqdTE///+y9eXxU533v/z5n9hlJo30DSUgCJCSEALGLfTHetzhO4tpJY6ftTdIl7W3vr01vmvSXtml+XW4S103SNP6lTW3j1DWJF2zABrODQEZiERJCICQhEJLQNpr9nHP/GD2Ho0FgXAOSyHn7NZaYGZ05c86zfJ7v9vRy5swZTpw4wZkzZ+jv7+ehhx5i2bJlTJ06ddTftLe3U1NTowfyp6eno2kanZ2deuZOU1MTZWVlVFZWsnTpUrKzswH0AFmz3LvJROK2i5FQKKT7IM+fP69nxnR1dRGNRnn44YdZunSpXp3Q5/ORkJBAIBBg69at/OIXv0CWZXJycli4cCFLliwhPz8fuNqpYHTBIVOQmJiYTFZaW1v54IMPqKmp4cKFC5SVlbFu3ToWLlxIUlISfr8fTdNwu90MDAyQlJREJBKhrq6OrVu30tzcTHp6OjNnzmTNmjVkZmaSlpamH98MTDWZiNwRy4gxLkTTNBobG9m5cye1tbXIskxhYSErVqxgxYoVqKrKzp072bFjB729vQwODrJgwQLWrVtHeXm5nu4mfJrX+3yzs5mYmEx0RGZifNZiIBCgu7ubHTt2sHv3bi5dukR1dTUPP/wwM2fOHLX9Rn19PW+++SaNjY3Y7XYqKipYvXq1vnEpxKpiA7hcLt0iIsrXm5hMBO6IGIFrG35fXx99fX383d/9HX6/H6/XS1FREVarlcOHDzM0NERJSQlf+MIXSEtLIz09XRcziqJc04lMUWJiYjLZMNYRCYfDRCIR3G73qKyZ+vp63nrrLQ4ePIjH42H58uXMnTuXpKQkjhw5wsmTJ+nq6qKkpIQNGzYwf/58PUNmLCuICK41swpNJhK3XYyIIKnriQJFUThx4gSvvfYar732Gl6vl1WrVvHkk08yb9686/o1NU0jEAiMyss3nov43fSLmpiYTBbEuCU2xAOw2+2EQiHefvttXn/9ddra2sjKyqKgoICdO3eyaNEiHn74YVasWDFq0zvxMz5IVcTZmWOjyUTijlhGxN4JooOIPRTEbpU+nw9VVYlEIni9Xnp6evB6vbhcrlH7M4g8eLvdjsViuaHqF5gdzsTEZCKjKAqapt2Uy6Snp4ddu3bR0NBAMBjkwQcfZMqUKUyZMkW3coxVSFJUt7bZbKPK15uWY5OJwh1z08SjKIreaYQoEXU/jJ3JWMI9nrF8nqYYMTExmUxEo1EkSdLHvGAwCIDT6dS30BAl4MUiLBgMEgwGcbvd+vgYjUZRFGXUdh1ibDUixkgz+9BkIvGJxYiJiYmJiYmJySfBNBuYmJiYmJiYjCumGDExMTExMTEZV0wxYmJiYmJiYjKumGLExMTExMTEZFwxxYiJiYmJiYnJuGKKERMTExMTE5NxxRQjJiYmJiYmJuOKKUZMTExMTExMxhVTjJiYmJiYmJiMK6YYMTExMTExMRlXTDFiYmJiYmJiMq6YYsTExMTExMRkXDHFiImJiYmJicm4YooRExMTExMTk3HFOt4nYGJiYvJri6aO/CKDBBqgMnqVKMHIs4AmiydG/h13POlmXlINz5rrUZOJgdkSTUxMTMYFFVQl9kBFAxQgCkRGHqp4n6aihIIo4WBMZYw8woHAVUGjKIQCYZToVVFjfMT+REW75hUTk/HHFCMmJiYm44EGuiAYMWMI0SB+RpVo7F+ShsVuw2KPGbM1DYKBCHanCzSIBoKoqorDaUcesXf39w/rukUcO+7DTUwmDJKmaWarNDExMbnTaCpokdjvkg1Nkg3WkJhbxQrIaghJiYLVClgwetfVUBBZksFqA1lCUyGsRLFYrEiWq5JDuGjkEfEjoY08K2OuSU0mAmYrNDExMRlPtJggiHeYSIZnNU0DVQVVJRIOo468WbbbQdZAiYkaSQZJkvjoJab0UW8wMbmjmAGsJiYmJuOFNvZ6UEgFRVVig7TNNvKMjCxDRNGwahKyEkGyWTCuKzVNw2K5jedsYnIbMMWIiYmJyXggMaaB4qpLBazyyL9UBTQJZAsWqxXxtGSxgRIlGgmiahI2hwv7SFyJLxDG5bLHHT1e/JjGcZOJgSlGTExMTMaNsd0l1+gURUGJKFhcNpDgSn+A8+da+ME/fIeB3m4GfD6mTM3ngYce4cFHHsXjcY0hRExMJi5mAKuJiYnJuKCOBLHKIMsoxFJ7IWavkFCJBodxOK0j6bsy4KCvb5i33n2Pt956g4wkK8XT8tAkCycbTnG59wqV86t4/LEnqZxXMUYAq/Hf8RVNTEzGj7veMjI8PIzH4yEajSJJEhaLhUAggM/nIyMjA4BoNIrVakXTNHw+H4mJiQD4/X7cbvd4nv6kR1EULBYLoVAIh8NBJBIhHA7j8XjQNA1JkgiHw9jtdjRNIxQK4XQ6AQgGg/rvJiZ3HZqMntQyBjLgcNrRIgEkqw3CYbA7+Pd//3e+98KPmTd3Dn//999DCQfwpKQBEs8//0/8w/e+z+CAnz/O+l/k5mYBoGqxdGBZjsWhqFEFu920nJhMHO56WezxeAiHw1itVhRFob+/H5fLdY0QgVgUemJiIuFwmEAgYAqRW4BlJJJODHwWiwWPxwNAa2srXV1dRCIjmQCShNPpZHh4mEAgYAoRk7sfCUC+puxHzE0TS8MNDvtjr9vtnG1uZvfePUzJL+BLv/1bAHhSvKBGQdJ44oknWLt2Lbt3f8ChQ4cIR2IHliX0DBsJC5JkRriaTCzuessIQFdXF3l5edjtdmw2G36/n+HhYZxOp24FGRoaQlVVvF4vdrsdRVEYGhrSXzf576GqKrIsoygKVquVzs5OTp48yZ49e5g6dSqBQACbzUZKSgpz5syhoqJCt2SZmNz9xNaD2pjWkRH1oMWKngEcPXqUmpoa1t//KOvWrYLAIACRUAib20pObi4rV67k1U3/yc6dO1m+YiUZ6clXjzhiHbleFo+JyXhx14uRcDhMXl4eAIODgyQlJeF2u7l06RLnz5/H5/MRjUYpKysjNzcXRVGIRqM4HA5TiNwCJEkiEolgsVhoa2vjlVde4fLly3R3d5OdnU0kEqG9vR1VVbl06RI9PT0sXrwYt9utu29MTO5KJEZZRDSMpmpRmVXFlZAQe1GJcvbsWfoGBsmZkos/qJLicaEFh5AtMqAy7Btm2rR8cnNzOXfuHMPDw6SlJWORRsJTJJAkkCUJVR0RJiYmE4C7XoyI+Fyfz4fH48Hn8/HOO++wefNmtmzZoltCli5dyle/+lUWL16MxWLB5/PhcDiw6fn9Jv8dJEkiFAoRDAbZvn07tbW1fOlLX2Lx4sUEAgG8Xi8dHR309vZSU1PDpk2bGBgY4NFHH0U2R0qTXwfGsIqIlq+FQkgjqbqRkX6kKAoOu3PEehiLuXIkeQEIBAKkp6eTnZ1NOBxG07SYe2ZEhEhmrTOTCcpdP9pbLBb8fj8JCQn4fD5++7d/mz/5kz+hurqa9vZ2jhw5wubNmwmHw/zmb/4mL730EpqmYbPZ9FgSk09GQkIC27dv5/333+epp57innvuwev1kp2djcvlYsaMGSxZsoTy8nIkSeLixYsEAgHz+pv8eqDHchiJlViVbCN9QNOQZZnUjHQkSWJgYABvUsxq6EhK0P8qPSMdv9/Ppa5OPB4XTqdTFyBGMaJp6LVKTEwmAne9GLFarVgsFsLhMN/4xjfYsmULzz33HJ/+9KdJTEzEYrEwe/Zs/vAP/5Ds7Gw2bdrE3r17cTgcSOYy4pagKAoNDQ2oqsqjjz4KwMmTJwHo6+vD7/cTiUQoLCxk9erV2O12Ghsbx/OUTUzuDNcpeqY/LayD0SgWh4Py8nKyc3NobWunpy9IJByOva4oaCNxVjU1NfT09DBv3jwSExN10WE0NJoFHUwmGpNejBh20772SVTQoijRIIMDvRw8uJ/i4mJ++3e+jDc5HQ1ITUkFVBYvXshnPvMZTpw4wWv/tRnfcIDhUHjs45vbb38sTp8+TWZmJpWVlYTDYYLBIOXl5QCkpKTgdrux2WxkZmYyY8YMLl68yP79+8f5rE1M7jxXtcnIBnZRBSQLWKwgWykpKWF6cRGdF9o4uH8PFosVohpYbEhWO4MDgxw6cJCEhASWL1+Ox+1AAhQFLAbho6qmGjGZWExqO7hGrEiQSmwvS5mRoHONkQh0BQjjdsps3/YeFy6cY+N9j+JNSWc4rGG1gwUVokGQrCxdsohAMEx750UudPcxbVouI3tqXj2+KFSEEntGpOaZjEk4HEaSJKLRKKWlpQwNDfG3f/u3uN1uhoeHkWWZaDRKMBhk+vTpTJ06lVAopPu7TeuUyV2PdHX/3KvE/hXFjlWyxQYgSSYjM5v/9T//iK9/4y/4yz//f6gsfZW8qbnYrTY6L1zgG3/xFxw9Ws/X//TPmDtnNlZhFbGMNsLY7Ga/MplYTGoxAjEhcq3lYuQVTUXx+7AkuGg/f55g0E9qaiqSBTweiWE/JLlUkCWGRzJtnE4n59vaCUWi+nGla46vjYgdiI0SJtfDbreTkZFBKBTiyJEjzJgxg7S0NK5cuUJ/fz/JyclomkZqaiqRSITGxkZsNhuzZs0a71M3MbmjXCsPZKw216gXNU1h/bo1XOn9PQ4fPswXv/gcNpuNpKQkgsEgycnJfOUrX+Hpp582swFNJhWTXoxAXCeOq39sSfCApOqVQCVJIxKJmT7dbui5eIn07AycTider5fS0lIudHXTdbGTkhn51x5f/1DTGnKzJCQk4PF4aGpqIiEhgd/6rd8iHA6jKAoDAwNYrVZSUlJoampi27ZtTJkyhXnz5plWERMTrlYxBvS6PE888QS5ubm4XC69ZlIkEmHFihVUV1eTmJhIJBIxswFNJg13hRi5Bg1iLpTYTpe+vivMnz8fh8NBS0sLTocFnx8kO6RnZAEq4XCYEydOcOnSJUpnlVNaWkpUBaupOT4RmqbhcDhYsmQJZ86cYffu3ZSXlzN9+nS8Xi9Tp04FoKenR8+iSUtLIykpSS8hb2Ly60w4HMblillIJEnSCwkuX76c5cuXMzg4iMvlQlEUvWpxIBDQswJNTCYDk16MxEr9XAcJiEZxuxNYsGABeXl51NXVcaHzMjm5mfh8Cl6PBZQIrsREzp49y8mTJ7n3wYfJykwmHPkoA4ipVD6KYDCIy+Vi4cKFnD59ml27dnHo0CHmzZtHSUkJNpuNy5cvc/z4cdrb2ykuLqa8vFwffE1Mfp2JRCL6vk1iuwq/34/D4dCtJUlJSQCjhIfdbtdfNzGZDFi+9a1vfWu8T+KTIGI69If+xEikhxpFctiQZYm+/gEO1XxIy9lWFi1cSXq6GyJhJFnm0IGD/PMPf0Tx9Jn8jy9/mZSUNKw2C7IkAlfFI84PJMlcx5FjQmyA9Pl82O12srKysNlspKen4/F4aG9vp7GxEVmWSUhIYObMmaxbt47p06ebBc9MTIjtnWWz2ZAkicHBQb0QYyAQ4NChQxw/fpyZM2cC0Nvby7vvvguA1+s16/SYTComfWuVUNGuZ6GQJLDbAJVIJMpnP/tZhgMqW97dwb/9279x78YNJNgiXOxs5+//4R9pbe/gX/71ZyyomovPH8b2kfOhKUJuBrEfUFZWFo8++ig+n4+enh4aGhpIS0tj1qxZ5OXlxWoijOxjMzQ0hNPpNM3MJr/WGN2UqqqO+n3Lli20trby4IMPAjEryq9+9SuGh4fJy8tDlmWz/5hMGia9GIGYIJHHEiTaSK6+FsHp9pCfn8if/9nXKZxWwg9//CL//uJPCAcHSE9NYuWatXzvn16gpGQWQz4/CQnuUTYQ2XhMiZH0XpOPIhwO43A4CAaDQKwIndfrJTk5menTpwPou/aqqoqqqlitVjMTwMRkBL/fj9vtJjk5WQ9mdblc9Pb2EgqFgKsp9K2trfT39+N2u03rosmkYpKLEVF47HqWEUCSiYZVVCmK3e7CarXy+OOP88BDj9Peeo4Ur5Nw0EdqRiYZmZlAbCUvvD23m2AwOCroTFEUEhJi5Z2j0ShWq1XfMC4YDKKNlIV2OBx6gKeqqkiShKZpRKNRfXO5ibDRnPh88R2Ba7JkzNWbicn1MfZh0XckScLlcuFwOFAUBbvdTjQaxePx4HK5CIfDo/rcREW7iVKwYsxTVVVf3BgDeU3uDia1GLlqsYgJEslYFEQUI9NUrA4nihIBZGQZEhNdJGqQklQGagSrTR6JMYm5CByO2OQ4HAzhcTpGfZ6uUPTI1k/WGZxOJ6qqomnaNUGboqMpioLP59NFSjgcju1N4fWiaRqKouh+ZaOf2OyoJiYmkxlFUbBarYRCIVRV1cdIMe6ZY9zdw6QWI2AMKB31pP4zGAjgdNmxWKwoqoJFtjA06CMYiJCZmQLWWICl1WrVrQwiCl1TIkiMlVp6eztANBpFVVXdYuByuVBVlaGhIRITE7Hb7ciyjKZpulVEP7OR5zVNM6PpTUxMJjVWq5Xh4WHOnDlDOBymuLiYhIQEvWSAyd3DpBcjY2KwkGhijwdAlmPCpbb2MM2nW7n//vtJ8nrYsuUtbDYbGzZsICkpSS8slOhJuO5H3LJTHTFBCoSrxu126yJDlEdvamqisLAQl8uF2+0eVQzJiCRJ+orCxMTEZLLS0tLCa6+9Rl1dHfPnzyctLY3U1NTxPi2T28BdMFuNHTOiAUjgdLnQUNA0FVmS0dA4efIkB/bVMH/+fKJKCvsPHMLtclBdXU1SUhKqqqJEw1hHVTyTrz0+nzyuJBAI4Ha7AUZcRA5dnESjUc6cOcPmzZvp6enRhVIoFOKee+5h3bp1oywoZsVFExOTu4na2lqOHTtGRkYGq1evJiMjQ4+lM8e7u4u7QIzAjQNZZRQtjBqNYrfZkZAIh8P4/X6SkhKxyDZkWR4pFR+TFh6PB1BRolEst9m6IEyNIm5EWDo6Ojo4evQozc3NXLhwAYCCggJOnjzJ0NAQ27dvZ3BwkIqKCmbOnInVatVrEpiYmJjcDciyzNSpUykrK6OsrAyHw8Hw8DBJSUnmWHeXcZeIkRGEaybOXKFEVWw2B6ChaioJHhcejwe73Y7NZsPpdOL2JBrcGrG0XUVRDGLkqti5lZtv6/EpmqZ/fnd3N7W1tdTU1JCZmcnv/M7vkJmZSUdHB5/73Ofw+/3s2rWLd955R99sLjc3d5S7x1iTwMTExGQyMmvWLJqamtiyZQu9vb08/fTTZI5kPQYCAbNS813EXRCKfDUmZBRil0s0QEYaeV80Gh2xRqj09/cTVcIMDw8TCoV0y8iwzweA/Q4ESEWjUcLhsC5KwuEwHR0d9Pb2YrPZ+NSnPkVFRQW9vb38xm/8BhcuXCApKYn169eTn59PXV0dPT09AKNiRG6ZGLmB8vpIUaZd53FTf2xiYvLrTllZGRs2bCA5OZn6+npaWlrQNM0UInchk9wyMkZMh3TtLr4OmxNh7bBaJIKhCIoWxWa3oGkKLqcdVYlgtVrRNA1PQmyvh+vlsd/K+iMiWlzUElAUhc7OTi5dukRxcTFerxeIlXoW+P1+EhMTWblyJXv37qWxsZHc3FxSUlL090QikZuqM6AZdvaRxDXURr0BwxtG/U3MViTHvXw9ERR37JsVI4aMIclwL7QRsSVZZD3ND0YLMvGcLMu60BR1Da63I7DIZLJYLLclG8mYKSXOwefzoaqqvscITKz4n2g0iiRJ+vUQ19VisYy7BU7UnxD9VAh7o8VxMu/+LGoJGa+5qB9kt9tHffcrV65gsVhQFIVAIHDD/i8y7m51amx8/zIG2SuKgiRJo+6V6GvGtu7z+Th+/Di9vb2oqkpfXx99fX2kpqbicrmIRCK3LDhfuMdFO4nv8/GbdUYikWtKKIxFNBq9YxsVxrfxcDiMLMv6fGas5SJJ0oTtD5NcjMDNG3fGet/EcGWIAVWSJHw+H5FIBJfLpZdI7+rq4vLlyyQlJdHW1kZqairRaJTi4mIOHjxIR0cHPT09pKWl6QNVLO7lxogmKhxQGiN7+xhfFL/HtV817qcc/zZRoVYbqzLu9Y97DZKEbLGgKgpqNKoPZFfTl2W94Ft83A1cW2vF2BFFxVdZlvX33eoMJCGUxMBkPH44HCYajer1Y4LBID6fj6SkpGsmmvEk/poIEXK9bK47jfGeGguE+f1+fTdb4yQomAxCxVjAUFgCxMZ5w8PDuFwuYzAqPQAAIABJREFU/XukpaWRkJCA0+nEYrEQNfSX+Enodk1K8ceMRqN6GzG2FTHeCcGkqio+nw+Xy8WxY8d4+eWXcTqddHV1EY1GiUajzJ49m6ysrFta1PF6/UtRFFRV1YWIuMbGZAG/34/H4xklwITAu9OZjMYFg7gmonKvOC9BvDiZKNwFYmTyIwaZcDg8Ssl6PB7efvttfvGLX3DlyhUaGxv54Q9/SFpaGrIsM2vWLH0DLb/fjyRJ+gD08TvDx5n0ru6VfP2/umqpAm5sCbmZ/iBLSFy1jsT/iXEFEolEaG5upq2tjXPnzlFUVER5ebkeVxMOh4HYJHuj63QrJitR3l4cLxQKYbPZ9EFDrF5aW1s5duwYkiQxd+5c8vPzJ9RAYRQfQrxpmqaX8h8vRCVOMRAbJxeRpTaWYBLViieK9el6iDZwo0k3Go3qbua+vj49Q89isehjiXH1fyvb1Uf1ETGZi8lSWClFG1JVVd/Z2+PxYLFY6Ozs5Pz58zz22GNUV1cTDAZJSEhg8eLFZGZm6iJdWItux/mLtiQyd+IXMTabTbdaGxEWkTuF6JNWqxVFUUYJNKPV0mgZNs4xE2ExITDFyARC7Dlht9sZGhri/PnzTJs2jTlz5nD27FmSkpJIT08nJydH7yiBQGCUi0YUbhsPbsfUKdwV11vBGM3ywWCQ9vZ2jh8/TkNDAxcvXiQjI4PTp0+zbds2ysrKWLVqlb4nzlgdN97y8kkHbuPfRyKRUeX6IVZH4ejRo9TV1QEwZ84cIpHIhCjlb0QM/sbzN64Uxwtj4LcRsSI3Xn/jQHwzpvaJhLBG+f1+nE4nVqsVu92uu3glSdJX68KNISZSYNQEdCu5GZEjXJPG9mwUtuFwWBdPouR7NBolEomwaNEiva6IWLSJNngrYkZu5LYVbUSMDUYLLIxtVTG2KeP1vxPEu5ZFcTgYvY2A+HknRdPNMHl6411KJBIZlVrscrnIyMjAZrNx/vx5HnjgAcrLy3n99dfZvn07Dz30EMuWLSMSifDSSy8xNDTE+vXryc7OBq4q3Xhf5/W5wb4+N/l30nWeH/N4Y8Sg3PBT4jq88XppmobdbkdRFNra2qivr6e2tpauri4yMjKoqqpi7ty51NXVUVNTw3vvvcf58+dZvnw5CxYs0Ac54wAjzKy3agUprFWiZL8YkC9evEhzczPvvvsuvb29uN1uFi1axKJFi8jOztYtD+NtHTGKIhGPEIlEdPfTeAumSCRCKBTi8uXLqKrKlClTSEhI0O9hOBzW43OEFWUyVScOhUK62AgEAqOseYqicPnyZVpbW3E4HPh8PhwOh74wGR4e1lfvt8stc702KkSKceUO0N/fT2trK4ODg8iyzPLly0e5XQAWL15MfX09O3bsICcnh4ceeki/l8KaeKvEunHLDRh9ncRY0N/fT0dHBw6Hg5ycHD22S1hBjAuYOy1wLRYLoVAITdN0l1d/f7/eVpKTk0dZosR3NP6cKJhiZJyx2WxEIpFR5u/i4mLOnTtHS0sLW7duZebMmaSmpnL//fezdu1afD4f586d4+zZs6Snp1NcXKwHdomB99ao3htsQjjyynWbs9gj6LrHHXldurF7yNhhjKsp8Vp3dzdNTU3U19dz4cIF3c1RVVVFeXk5qqpSVFREVVUV+/bt48iRI7z88sucOnWKqqoqqqqqronlgI8OdL1ZxOpKHP/KlSscP36cmpoaTp8+jaIozJs3j+rqambOnKnHj0wURHEpIQAnQgyLEYvFQlNTE5s3b6a9vZ3y8nJmzJhBUlISaWlpZGdn43a7R7lsJtqK8EYYFxRiywqIBbQrikJDQwMvvfQSLpeL4eFhPcYCuOHO17cqgFVM3vEWKBGPJSxnQ0NDnD59mtraWs6dOwdAcnIyFouFBQsWANDa2oqmaeTm5jJ37lz27t1Ld3e3fmwhQGRZ1sfMWyEqhZvPeC2E1bm2tpazZ89y/vx5VFUlJyeHmTNnUl5eTk5OzqjjRCKRUXFUd2qyF21iYGCAuro66uvrsVqtFBUVsWbNGn1hM9ExxcgEJC0tjYyMDI4cOcJ3vvMdpk+fTnV1NSUlJTQ0NHDkyBHOnz+PzWZj6dKlpKWljdqjRlXVT7Zjp6SOCAmDu0dsPDgW1wtEHTNeRBSoG3ldEiX7x0ZFu7rVkEVGGtmNqLunm/b2dvbs2k1nZyeBQIBp06Yxf/58ZsyYQXp6+qhr4HQ6SU5OprS0lMbGRs6ePUtdXR1DQ0NkZmaSl5dHRkbGqFWRMd7jv4u4L8FgkHPnzrF//37q6+uJRCJkZmayfPly5syZw5QpU4DRmSoTAVmW6ejo4OLFi9hsNjweD4qi6IPueK+ubDYbTU1N7N+/n/3795OWlkZaWhput5vc3FzuvfdevQ7PlClTSE9P1837EyVA+GYRE3xTUxONjY1omkZ+fj7d3d14vV4uXLhANBqlubmZI0eOUFZWpi9wrFbrmAG8n5SxLC4ivkhVVaLRKB0dHdTX19PQ0MDAwABut5u0tDQ8Ho++L1hTUxPbt28HICUlhY6ODhITE/X3iEBk4fq4mQD9m8EYxC7o6+vj3LlzXLhwgTfeeAOHw4HT6URRFGprazl58iQtLS1UVVVRWFhISkoKsixjs9lGxbHcCQEgXHOXL1+moaGBw4cP093dTUlJCR6PR78/k6Gdm2JkAiBMyZqm4fP5sNvtBAIBzp49S0dHB36/n4KCAvr7+2lqamLmzJnMmDGDoqIi5s+fr5vqRLyI2JcmGAx+AlEyVr7MDSwlBkEyyhNj3EkZdUToaDddT98iXzspX+6+zIEDBzhw4ACXOi+SmZnJsmXLqK6uJj8/f8zjOJ1OCgoKyMnJYcqUKSQnJ9PU1MRLL71ESUkJixcvZvbs2WRmZuoD963owJqmcf78eU6dOsWJEyc4ffo0sixTXV3Nhg0byM3N1d8nsj6MqZDjLUra2trYunUrO3fuZGBgQDeRT5TgT+HCaG1txe/3E41GaWtrAyArK4szZ86QlZVFRUUFS5cupaqqiry8vEkzQBs3wxwcHOTixYu8+eabXLx4EUVReOaZZygoKKCwsJCjR48yMDBAa2srW7duJRwOU1ZWpgtqYzr5reJ6xxOWl5qaGhoaGjh27BiaprFw4UKWLVuG1+tlcHAQt9tNKBTijTfe4OjRo8yYMYOuri6cTicbNmygvLwch8OBxWLB6/WOEiS3otaI6Oci+LOvr4+TJ0+yb98+Tpw4wezZsykpKWHu3Ll4PB5OnTrFgQMHOHbsGI2NjWzcuJHi4mIKCgr0tngn6e7u5sSJExw4cIDW1laSkpKorq5mxYoVFBYW6oHD8ecl2tV4jy9G7goxIlIn4aoPU3TAUCikT8ihUIhgMIjdbsftdpOQkIDD4SAYDJKUlKSv9Iy5/UZ/YLwp8mY2oxNR+/EBc+J4xm2xFUWhsbGRHTt2cPbsWTIyMvja177GtGnT9PojHo+HiooKysrKSE5O1o8nxIwsy9jtdv17C9UvMjmMOf2RiILNdoPGKGmgKIRDEexuz0iqWMyNEI6o2GQZqwyqohCJKDhcdl2UXLzYQ1ZOOpoKVgsjpfVHrmUohOSwxN6IBRWIKrG4Coc9ZnJU1Ng9tVqsqCP7CgWCQWpqati+fTuXLl0iNTmZdevWMXv2bGbNmnXNwCQmc+O9stvtlJSUkJOTw6pVq/jlL39Jc3MzP//5zykuLmbt2rXMnTtX36NI3CNglEgQr4n9hCCWmquqKm63G03TGBoaoqmpiT179lBXV0dycjIbNmxg0aJF5ObmjjLBjxVQOREGCq/Xi8vlorOzk127dunPi3MPhULjdWqjsFqtOJ1O3VWZnZ3NtGnTyM3NJTs7m6KiItLS0sZt24RQKISiKLhcLn0cEUG28e4S40o9EokQiURoa2tj3759HD58mEgkQmVlJfPnz6eqqkp3QU2bNo3i4mIOHz5MY2MjL7zwAlVVVVRWVjJv3jySk5N1F47Vah3VN8RzAuP4BNfGbonJ29jnhEiIRqMcP36c2tpa9u/fT0ZGBiUlJVRUVDBv3jw9VksI8dbWVrq7u+nu7ubrX/86Q0NDRCIRpkyZQmFhoe6WETFi4hoZXdNj1dqw2+36OYk+K+67MUZEZPXU1dWxfft2mpqaSE1NZfXq1WzYsIGpU6fqc0hWVhalpaUcOHCAffv2sWXLFhISEqisrGT16tVkZWXp81F8bIvIeBTXzO/36zEw8dfdiKZpeqC+0d3b3NzM1q1baW1tRZIkVq5cyerVq8nNzdWDga83P41VU2W8mfRiRHTc+BsoGp/T6aS3txdJkkhNTdXFx4ULF+js7CQ7O1vvdD6fT08vE4jOK+IwRGO52fTZ+IwDRVEIBoM4HA59BT4wMEBTU5P+GBwcpLi4mNLSUpYsWYLX69VT4BISEsYcSMX5GQcQcf5CsQtxIhhTiEgjbhRRcMRi4fXNm8jMziEUjjI0FGD6jBIq51UQDkapPfohg/1XkK12hv1BFE1j4333kZWTHjucJaZPAqEwTkXibMtpmk6eIDHBiSrJlM6twpuaidPhxGqxMjg0yL59+/TAPZvNFtutMzWNtrY2du7cSUtLCxUVFaxdu5bp0wpJT0/X79lYpnfRFoyveTwerFYrX/jCF6irq2Pfvn20trby+uuv09DQwNKlSykvL9cHbSOhUEifVMRApyiKPmCJok1nzpxh9+7dpKSksHz5cmbPnk1RUREpKSmTZvtzr9fLsmXLkCSJVatW4RupTiwqB4+V3ngnEZYnsZrOzc3VH+np6Sxbtgyn06kvPAQiEPcTuTNvAmGdNH620Y0hhIhe2G9kbIlEIgwMDBCJRDhw4AAffPABV65cYcaMGSxfvpzKykrS02N9TARIOxwOFixYQHFxMTU1NRw/fpwDBw7Q1NTEqVOn9DYo0slFHYr4cczoKozvS4FAgGg0SmJiIi6Xi0AggN1u1ye/lpYWPZD83LlzzJ07lzlz5lBZWanHWIhMGTEpZ2Zmkp+fz+HDh+nq6mL58uXX9A+bzXZNbRtx/iJdXmQUSZI0SogMDw/rgsV4TwSnTp1i7969HD9+HL/fT2lpKatWrWLBggX6scR5S5LE1KlT2bhxI5WVlfz85z+np6eHd999l6amJlatWsX8+fNxu90MDg6SlJSkCzcRmybGISEijYhAXbF4EvdAXI/+/n7OnDlDfX09zc3NnD59mrlz57J+/Xrmz59/29vz7WTSixFgVMc2dmjRqdPS0oDYwBUMBnG73UQiETZv3kxycjLnz58nKytL75Ti51irVWPmxc0gGqQR4e8Mh8O0tbXR3t6um/5SUlJYt24dixYtIiUlhcTERFRVZf/+/Zw5c4bp06ezcOFCHA4Hg4ODJCYmXmOGMwZ2xZ//xzMjquzeuZMf/vCHHDtxkv6BYSor5/HV3/19SsvKCQaCbN/6Dr/Y9CoNTU1YbE6qFi4kNT2TqqoqNCk2eKWleEhIcBP2D/POW2/zHz///7nSe5n+gUFe3PQaDzz8OABX+mLBna+88gp79+5lcHCQxx57jIKCAtJS0+jo6CA1NZU//uM/pmp+Vey7Gs42fvUkroHRumW8Rm63G1VVWb58ORUVFezfv59t27axY8cOzp8/z7x581iyZAnJycl61o7L5dIHkYGBAV3UWCwWIpEInZ2dHDt2jIMHD9LQ0EB5eTnz58+nurqarKws/fMnQqbMzVJUVERRUdGYr413YJyiKLS2ttLV1UVSUhJ5eXmjLIbCuhl/rW9Xhd144icHYYkYa0EhVr+SJNHb20tbWxs/+9nPUFWV5ORkli1bxrJly3RXpJhU479bSkoKK1eupKKigrlz5/L222/zy1/+ksbGRjZs2MDs2bPJzc3F7XYzNDSkjzFXrlzRi6ZBbOJzu93YbDaCwSDBYHBUlecrV67oVo6+vj6OHTvGm2++yfHjxykpKeGpp57SXZ/GiVf0F2Omzfz589mxYwcvvfQSRUVFFBYW0tbWxunTp7HZbJSVlZGRkQFczRR0u92jXDXCxS2urWibwiIqnhP3vb29ncOHD+uWpJycHB5++GFWrlw5qg0JjNaEpKQkkpKS+Pa3v83+/fv51a9+xYEDBzh9+jSrV69mzZo1FBcX61ktRguSyH4Rz4lr63K5cDgc16RACy5dukR9fT0ffvghbW1tBAIBvva1r1FSUkJWVhaiTL7Y+X0iuHk/DpI23qPJLSS+MJMgFArpA1J3dzcvvPACL774IgUFBUQiEQYHB1m7di3PPfecHvhjsVjw+Xy43e4xfcsfN9siEAiMUrg9PT2cO3eOvXv30tDQQDAYZNmyZdx3331MmzZN/7va2lo+/PBD3US+ceNGNmzYoKfyiiJnY7mT4stkx1tpooqGxSKNigSJ/UvBGLza2d7Oj/7lX3nv/Q/4gz/4nzzy6KewOWSiQRWHrPLjH/+Yf//5Szzx2c/x6GNPkF+YE7OGBMDlAv9wmEhwmOQEFxa7RKi/l1df+Q++8a1vk5CZyz9+/wXWr1tPIBgrYS0sINFolIceeojU1FRsVhtRJarfS4iJjwS3G4sk69YJUVBsLMaqiWC8j9FolK6uLj788EP9vqxcuZKFCxeyePHiUe4042cEAgF8Pp8e8LZjxw4KCwt57LHHWLBggR6HYrw/k6Xo1tDQEDabbdR1NbaxiTB8xA/u4jljBU3BeKQ1GotRxbfNYDCoT5DCvXrq1Cm2bt3K/v37yczMpLKykpUrV1JaWqpX5jUW/hJtSFVVAoEAcHXBMzQ0hCRJHDp0iJdeeolz586xZMkS7r33XgoLC8nPz7+mJsvAwAA2m00XEOFweFQA7JUrV5BlmeTkZAYHB+no6ODtt99m27ZtJCcn88QTT+gpu0JARKNR/H4/FotFP7crV67Q2dlJb28vU6dO5dVXX+VXv/oVP/3pT5k9ezbNzc28/vrrXLhwgfnz5/PII4+QmJhIKBS6JoBVWEnE793d3RQUFDAwMEBiYqLuqg4Gg9hsNg4cOMDBgwfZvn07s2bNYsWKFSxevJi8vDz9mGI+gdFWIuFyk2VZF27CgvXyyy9TX19PRUUFDzzwAGvWrNEXjMFgUHeji3svSdI1bVQI1mg0itPppL+/n+PHj7Nr1y5qa2txOBw8+OCDPPzww6MsW8FgcJQb3ufzTbjsvBth+da3vvWt8T6JT4Jxk7n4NDNxQ0X8x5tvvsk///M/U1NTw7Jly/jmN7/JvffeC8DJkydpaGhgeHiY1NRUUlJSdPeGiAoXFhjxWcaf10OIBWGii0ajtLS08Pbbb7Np0yZOnjzJokWL+OIXv8g999xDamoqqqrS3NzM/v37efHFF2lsbCQrK4unnnqKhx9+mMTERPx+/6gVgHGCFtejp6eHrq4uZFm+xv2kqipRRcUiy2iG/XykUTvaqfRe7iIrdwpnz56js/MSv/mbz5KRkcrgUJgEtxVkGSUY4tVf/CfLli9nxcrVXO7uJyHRiWwDVQOH3YLH7UK2ymihAKoSRtYUsrJz2LX/EB2Xuli0ZDHpaRmEImHsDjv+QIDklGRml1cwHPATjkZwOpzYbHasVhtWqw2nI7YTs0W26Csso3A0xvwY71W8FU1EpLtcLpKSkigpKSElJQWv18u//du/cfjwYTo7O8nJydGr34rr3N/fz5UrV3jzzTf5wQ9+QHd3N8899xzPPvus7i4QA6HYM8JY82Kir1yM7kQYnbYpzt/Y78bjYbVaR4vsEdeksb5I/MPYBm4nxlgF470Oh8O6mygajTI8PMzw8DBbtmzh+eefp62tjZUrV/L5z3+ehQsXUlRUpFsThMk/vh6OcCkIK14kEtGtB1OmTOG+++4jIyODnTt3smfPHvr7+8nKytJX5AKn04nNZmNgYEAvLS++iyzLuFwuve2/+eabPP/889TW1vLoo4/y+7//+5SVlZGQkEBycjJ+v193aYsVO0BHRwd79+7l7/7u76ipqWFgYICuri4GBwfZuHEjWVlZekB+Q0MDp06d0rdKELEmFy9e1IP+jffT4XDolg1hhenr68PpdBIIBOjq6uL73/8+hw4d4tOf/jTr169n/fr1+t8IgWh0kxjdaZqm4XA4Rk36iqIwY8YMVq9eTV5eHqdPn+a//uu/6OnpIRQKkZmZqY/BwiUnXLxCTITDsU1bRcCu1Wqls7OTV155hZ/+9Kd0dXWxYcMGnn32WZYvX47b7dYFiDieiAMyupcmC5PeMiL8haI0dXyJb7/fz/Hjx3n55ZfZs2cP5eXlfPGLX2TJkiW6318EXL399tvs2rULh8PBZz/7WZ5++ulrPs/o573ZgWxoaEg3v+3YsYMf/OAH+Hw+1qxZQ3V1NXPmzCE1NZVgMEh/f7++wn711VdZtWoVK1euZOnSpeTn5+vfLRKJ6Cs/4RvVtNh+FQkJCYTDYU6ePMmmTZu49957WbNmjf53Ir5BA9BAla5nGYkJr+FBH3/9ne9ysqGJv/7r7zKrrAxFA7sMfZd7OX+2hSc+81l+/w//mN/72lcYDoF9xDodjkAkFCQ5wYlEFNQwQ91dnG85TRSJbfsO8xff/g5f/epX+cu//EsgZmk4ffo0bW1t3HfffSSMBM0Gw0EikQiJnlj9hOFhH0mehFEJOfEWq3jLkXiPeF+8yVyU5Bcd++TJk7z33nu8+eabhMNhHn/8cT7/+c+TmprK0NAQmzdvZuvWrXR2drJhwwYef/xxpk2bhsPh0P2/oq2IgLLJ4p6Bq5uZidV7fEbGrSjJ/UmIXxwIxD0Xq8/xqpMSn/ERvwGiiFPbu3cvzz//POfPn+fBBx/kkUceISsri4yMjDHPWVgCjQGd14uVMo6PmqZx6dIl3nnnHd566y0uXLjAs88+y6c//Wm8Xi/BYJDExMRRCQBCFITDYT3ubOvWrfziF7+gtbWVdevWcc8991BcXExSUpL+/UTbj6++CvD+++/z4x//mMzMmEtXCIWCggLWrVtHf38/ycnJRCIRLly4QCgUIjU1Vbe0vPPOO3zve9+jp6eH4eFhfvd3f5cvfelLuuXB5/Px3e9+l1dffZWhoSFKS0v5oz/6I5YvX05KSgp79uyhsLCQqVOnAjEBItywxoXdWJZLo4gdq7hkKBSipaWF5uZmnn/+eZKTk6mqqmLjxo1UVFTo8S/G+xXvYm5vb+fIkSN8//vfJz8/X7fOzpgxQ7f0xLvnxTUX92kyVRiGu8AyIgZ3MfgIFT84OEhLSwsvvvgimzdvpre3l8985jM899xzlJaWYrVa9f0cbDYbiYmJTJ06lZKSElRVZd++fWzatIn8/Hy9XLHxs+DmTL2XL18mNTWVhoYG/uzP/oxNmzaxZMkSnn32WSoqKliyZAk2m41wOExXVxf/+Z//yfPPP4/f7+fZZ5/loYceYsOGDaSkpOD3+xkaGtJLJwtFbKz5EIlE9OCt5uZmXn75ZaZPn05paam+42d8UObYlhEhSDR8g4PU1R9Hlq2sWrUGrzcZSQa/L4I3OYH21lbee38HBdOKKC2bg83hxGqDYAQcNrDbrFgkIXRUIv4hTjUcB8nCmnvu48y58+zatQubzUZFRYVeDr+3t5fZs2cTCAZAAofNgcPuQEMjHAnjcrqQkdBGzKk3KkttHECM7zG6HsTALSwBPp+PxMREZs+eTX5+Pr29vTQ2NnLs2DG2bdvGT3/6U2pqaigsLOTZZ5/lySefJCcnRxd8xpWVaJuqqur7uUyG1FKxQhMr+3ghYvx+4/UY6xyESd7lcun3wehaEvf7dt8D4+cODw+jaZpej+LKlSvU1tby3e9+l1deeYVZs2bx5S9/mZUrV5KZmanXvRHnKjaMM4plgRC+IqNLtGGj1VgI75SUFAoKCpg3bx4Oh4Nf/epXvPrqqzgcDiorK/WgT2EVEy5eu93OgQMH+M53vsPWrVvxer0888wzrF69msrKylH74RizGkWbN+5PI9KPH3jgAR5//HHKy8vJy8ujoqICSYqlMQtLQnJyMunp6foCQjw3c+ZM3b1TV1dHaWkpubm5SFIsY6W8vFzvc4899ph+XSVJwuv1kpmZqVs4RRsX7j1xfY0ufuO1DoVC+P1+ffErEgyEYM/IyCA/P5+ysjIuXbrE9u3bOXnyJKqqkpiYqLcBMaeI8Vy4e1555RU2b95MeXk51dXVrF+/nvLycn3jO3FOIkPUeM6iMNxk466wjMRv3tXa2sq7777L+++/jyRJlJeXs27dOqqrq5Hlq5sfwdiBhPX19bz//vtcvHiR1tZWFixYoKeQOp3Oj1W98PTp07z22mu8//77pKenc99997Fy5Ury8vJ01d3R0cHWrVvZunUrgUCA5cuXc++99zJjxgw9XVFRlFFBYEYfqTE63JhKtnPnTn7605/y9NNP6+4o4+sDA0MkJY1UadQFibCMRAGVcDCA3enhr779Hb7/gxeoqJhHOKJikR0kJrhxyCotp5vo7uvnW9/+Kz7z1FN4Ep0ogKJCOKziccpYgKGBPpKS3ESG+tm7ZzfJKamUzl9Eny/AqlWr0DSNTZs2kZaWRmtrK6FQiBUrVuCwxVYePr8PTdN0y0g4HMJldyAxdk0O43NjpSiKAd4Y3HYj18n58+fZuXMne/fuZWhoiJSUFNauXcvChQv1nH7h5zXel/h4HeHimEwrF6M1aayYm/HC2A+FK9WYAmlM+TeK1TtlnRKfGW/JOHToEDt27GD37t3k5ORQVVXFihUr9LiQeK4nnIxZOPHPi0zA61lPgsEg0WiUXbt28cYbb3D27FmKi4u59957qa6uJiMjQ8+WOXHiBC+//DIHDx5k6tSp3HvvvVRVVVFWVgZctdTEBwYb01zh6rh17NgxfvSjH+H3+3n688+wbs1aJEmiv78fj8eDzWa7TlpurB8HAwGcLhf+YIjv/eP/4YfP/xPFhUX85Xf+mpWrVqGPzWS+AAAgAElEQVQAwWCIztYO3n17C7/3td8DC4Q1DU1TcMoywz4fNrvzuu6M+HkiPr32egQCAV0UKIrC4OAgR48eZevWrZw4cYIpU6bw0EMPsWbNGj2mIxqNUl9fz2uvvUZNTQ15eXmsWrWKjRs3kp6ePuY5xu99I8IShAicbIJkUogRsdHSWL5ro2rt6upi165dfPDBB/T19ZGcnMxTTz01yhxn7JDGGhxG64KmaQwMDDA4OMjPfvYz2traCIfDVFZWsnbtWmbNmjXm5G/Msz9y5Ah79uzhyJEjRKNRSktL9YBGiHXKYDDIG2+8QV1dHe3t7UybNo3169dTVVVFenr6TTcmMeAFAgHeeecdjhw5AsRMfY2NjRQUFFBUVMS6devYuHEjYMjyEXGqI9VQ48VIJBLGZnPyjb/4S/7j56/w8MOPk5iQjIQNi1UiGvTRcSEWcPp7f/CH/PaX/wcWu41oVOXP//f/5kpfD9VLl/HcF7+A0+5goP8KLruN7du2kZ6RQdncucj22Orsu9/9LtOmTeNP//RP8Xq9NDQ06PtSiP+MSHxESfpbhFHIhMNhuru7GRoaQpZlZs6ceZs/3WSyYxTFDQ0NbNu2jePHjxMKhSgvL9eDpO12+6jF0fXcBLeDCxcu8P7777Nz504GBwepqKhgwYIFuFwujh07xrFjx1AUhYqKCpYvX86sWbPGzDi5HvFCv729nZaWFv71xZ8wvWQmn/30k5TMnEUoHAJNxumwoaoQuxTaSPFE4TqOxbNpkoULvX1sfuU1krHwD3///zGlbAb/9OJPSMueigOJtuOt7Hj3PZ54+nN4czzEwntVElFGaiJZ+Hg7ln88jPezubmZ3bt309DQQCQSwePx6GnMLS0t7Nq1i8HBQaqrq3nggQeuK0zvVib80ix+BWmcGETD7uzs5MiRI9TU1NDS0kJiYiKPPPIIa9euJSEhYZRFwShG4nWY0YyfmJiI3W7nD/7gD9i/f7/eiC5dukRZWRkLFiygpKRkVGMRbpLOzk5OnTrFsWPHmDp1KmvWrGHFihV4vV7C4TCXLl2itraW2tpa6uvryc/P55FHHqG6upri4uKPdX2EZchisTA0NER3d7e+P0VHRwctLS2kpaXp5ya+v8fjQVVBvuEeMhBVFVBi/sxFixbxzW9+k9SUZAb6w3iT7aDC3j27aDl3jkRvAi6nnZZzZ2lqbkZVQqR4k/iXf/kRnR1t/NW3/wqvN5VoJILN7mZgKIBkseGwOXjyiSdpamri+eefx+Px8PTTT39kDQvtunXoby3GuBO73U5mZiZpaWmTplaIyfgRDAZ1t8eJEyfYtm0bTU1NFBQUsGjRIubPn092drZuCRCuJWNWxO1ExDxMmTKFZ555hnnz5nHw4EGOHj3KT37yE3JycrDb7RQVFVFeXs68efMoLCy86eMbF3lG601aWhqKFo1VY0314vS4UVHRVAmr9dqsrRhXhYioBi1ZZIKRMCtXrSfy5a/yvf/4Cf/4vf/D7/zhH1GUNRULFlKT0khweYhq0Bv2k+xwoKGOuI1vbwC5sE7ZbDa9avapU6fYvXs39fX1bN68Wd/7qbi4mCVLlrBo0SIyMjLG3ep4p5nwYsRoDhaWB/Gcz+ejqamJvXv3sm/fPiRJ0v1rxcXF15TnFQFVAqM/VQRaiddFHQqA++67jzlz5nDw4EE++OAD3nnnHc6ePcuCBQuYP38+ycnJJCYm6qLA4/FQWlqK2+2mqqqK/Px8fbvvY8eOUVdXR1NTE52dnTz55JOUlpZSVlY2IhBU3Rx4M4ORcULMzMzkqaee4oEHHiAUClFXV8cLL7zAE088wcqVK0dZW/TvKknXmc9j73M5PFy81EViYiIpKSk0NDQwb+4CvMl2AgEVhyUWNHv27Fl6enpQFIXk5GSKior4m7/5G2w2G1//+tc5dOgQx08cp6R4hj5Ae1NSGB4e5mLXJQoLCvnKV75CW1sb7733HpFIhM9//vM32UpuL8J6JrhTE4XJ5EdYUEWsQHl5OSUlJZSVlTF79uxR7xVjjuijd6JOhHELCVmWmTVrFtnZ2cyfP5+LFy/S399Peno6BQUFFBQU6GOiqqr4/f6PTB0VacMCY8GvvLw8Nm7cSCga0hcescwb4xh14+8fDUcIBoPkFRTw7Fe+zPaj+3n99dcpqZzH9M89EwvojAQJhyM4JBsehxsJFRUVyx3w1Ing4VAopMd0zJo1i9TUVKqrq2lqamJoaAiPx0NZWRklJSWj7smv0zgzacSIMY0wGo3qk/rOnTvJyspi9erVlJaW6kV2YHQ8SXyZeHFM0fGFGLneRmXCz1deXs6RI0d0/15nZyeFhYVUVFTom505HA7KysqYO3cuLpeLcDjMqVOnOHToEAcPHsTn8zFv3jw+97nPUVBQQHp6un5eIvJcWDI+qjGK4KVAIIDH4yEhIUEvYtTb28uCBQuorKwc5U64Gngo3dAqAtDd201Odo5uSoxtcGUnFAKXSwYtVtMgLy+P/Px8nE4nWU4nKpCYkEgwFORTn/oUw0NDsSqRI9Uog8EgiapKelo6aWnphCIh0lLS+JM/+ROampp47733eOaZZz6iddwZRNsQWSViD5lfp4HC5L+HiOmQZZmioiJmzJgxqt2IwE5Rg0iMd8L/fydSv+MXaBkZGXrWiqjLEX8esizfVA2LeCEiYj8kSUKWZIoKiwhEAlit9mvO5WbQNA0LEr19V8goyOMrX/kKrf/vt3j55//BjLxiZqZNQ9E0AqEgDmzYia29QqEQbrvzthtWRSCwWDSK+UWk/VdWVo4SKnDVmvbrNr5MmmwaWZYJhUKcO3eOmpoa9u7dy4cffkhubi4rV67k/vvvZ9asWfqW5yLKeaxMG0F88Jcxct0YrGdMl0pPT9erPHq9Xo4fP67vaiqybpKTk/Vc/dOnT3P48GHeffddPvzwQ1JSUrj//vu5//77KSkp0c/TWAQrvibCjRB59SLbRwSSieNmZmaSnZ19TWZH7LvG9cUR/+zVh4TFYuXDox/y+uub2bfvAGlpGRROm4HH4yEcjnKuuZl3t77Dm2+9hWyJib5ZZWV4PAlElSiDg4MEg0HOtrQwc+ZMXA4n+/fv58PaWlRN49z5c7HrYLEyPOwjNzsHVVHo7+tnQVUVM2fMjEWLSFejRvTwFkC+JpLk1iIGUBHxLtrRRK8PYjIxEILCmIEnfjcWQjMG14qF150IcDZWfTVaocWeOE6n85qg748T/BsvLoyfo2gKsjSSDSXF+pNFXKeR/+tjM4zEjIA+Pkky4YjGyWMnmTW9mCRvIgXF07A4rLzx1lucaWpmTkk5AX+AOVVzicqgWkBGw27VsEgyMTfN7RtBxL0X30OMv6IOjIiDNF6XGyVX3M1MeDEiIuS7urrYv38/77zzDnV1ddjtdsrKynjyyScpKirSzYeiGI1Ie4rv0CI1ztgojA3BmCpoTP80brAkyzI5OTnMnj0bm81GX18fx48fp729XW9APT09nD59mi1btlBbW8vQ0BCLFy/mM5/5DEuXLiUhIUGvQSA+X2RjfJz0YbFyif9eIr2toKBAL2dudNGMGZ2vixHxD439B/bz1a/+HhcvXsLlclNff5zEhESWLl1AR0cnP/nxj9i3fy8dFy7gD/hpa2sjLz+PvPx83Rzb2NRIeloaG9Zv4NzZs3z/+9/nl5s38+Zbb+F0u8iZEtvMTJIlLLKF4unFTJkyhbS0NKZMmXJVmI0xaFhu89JGXCdTfJj8d4jPLDE+Z3QTG4PnbzZT71adn6IohEIhPb5BiO2xxJCwDAqx8nFW78aUVEmS0NBQNSFudPkx8kGjx76xxIiEjD8Q4cPaD1m7cgWypCHZrVTMnsPFri727d7P2dNnSPAksmbDUqIqDEeCuKw2bMRKDUi3WYyI7yus7vFbloj3wNXMIzEv+f3+X6u4tEmRTXPy5EkOHDhAc3MzwWCQ3NxcFi1axNy5c7HZbHrA11gYG4CR+JTPj7JCjGWu7OvrIyUlhcbGRvbs2cOZM2fQNE1PxxWV+f4ve28eHdV55us+tfeuuaRSaUSzEBISQkhMAgxmNpgY8Igzd6b2Sbo76fTp3Jxzu3PPutfd557jtXLbfdLdSS87N+3bcRLHTto2xgY8YDOYeRCzQCAJAUKzSkOp5un+Ufo2uwqwsRkk4/2sxQKkGvfwfb/v/d7395aUlLB06VIWLFiAwWDA7XYjy4mW2KKJU2rWtLa75s2gNVYTp1R0hdRuTwUCAUDTM0N79tVqmpj6izhxmpubycubxKjHh9FoRTIopKc7sVhkhgeGCIb82BwOQpEwPT09FJeWYLUl7JrbLrRx4sQJplZUUDu9FkMczjQ1kZudjWIy4fF7MVksZGVmEYuPJScbJIKhYJKwup4YiRNHuQsJrFpE1EwIus/TYKHzyYnFYqp9uNa1E1BFgHDcTGU8V8aimZ3ZbE7Kl0r13Pg4PqptRpwY4UgYWZGJj93H8lhCaTwGkgTxMWfGRDVNhOQEVoXuXg8v/OoFfvjn38OR4cAf8mKyWGltb+df//WX/Pvzv+bhdY/wy3/7JYoFwog1lx+jQULGyJ2sphkZGbluM8LrmWdeLy/y88SEzxmBRBnYyZMnsVqtrFq1itmzZ5OXl3dDAaLdfrnRY0S5sJi8tasWbZ6KqOYRzoNaYxuXy6W6+1VXV3P06FF27dpFW1sbAA6Hg5UrVzJ16lQKCgrUsJxoLuXz+bDb7WoNe2p3yJtZjYv+Aw6HIymx12azqf0bxPcAkgTV6KgPh32s0ki99sWNmRAkBgyUlU3GYrZhQCYjI/HZw6E40Sg4MzPwjcrYHA4isSiZmZnEgVG/D4BNmzYxf/58aqfXMjQ8hCs9YVYkKwqRcJh0V4ZaXSwMiCQ5cYMaFSPR2I0dPu92Fb12xapHSnRuBkmSkhxY4Woum6IoSZV+olur1jb9TpPqVSGEdqqTderv4ebyO1IFlciFURQFSU7c4zFixIknJewmRMzHTcgGFElBlo1c6uyiJrMy8brEKS8p5ktPPM6R/UeIGaC7101RSSYyiZFtdNSLK815x+vxRJNU0T9JRKhFHppIA4hEIlitVjXhVRRbfJa8iG6VCR8ZCQaDDA4O4vF4MJlMZGdnq5Ps3azDvxkCgQAejwefz6eG90tLS8f7Y3002l0ZlatW8FeRkv8ee14kEEaxjG1hxRKDSRw4e/4c27Ztw2g08sQTTxCPRrlw4QLVFVNxZmQQDYWQTSb4+Bzaj+Tzt37Q0bk3iI+NMTFNq04Jbc6IhliccMSP0aiAIU73lct8uGs/f/f3/0Bf3wB5+Tn83f/9f7Js6cJEDp3VzsiIj/2Hj3LwUCPf/U9/RlbmVVEYiAUxSzIyEoa7vqzRuR4TXoxAQr0LW17tKuNu2Dl/HKkdLUWPgc92kmNM87f2+F7nWGuunlA4kejbfP4c/9+vf81vf/tb1Xo6Py8v0Rn5m99GkmVdjOjofM65GTESicSIRsOYTWZ1myYeCTE4OEBXZz9nTl1AsdjxhEaYf99cKsuKEX3IQ8EInlCEnoFBKspKkAHvsB/FJKFYjfhDftJNdn0MmSB8JmJAqSFDbcXLeIsREXITiDDbZ3vP72MEiJaxkG0c1I6hJSUlLF++XK0sikQi5GRlcd999yGNCbRwOJwQI+iCQkdH5/ooioQsm4jHYkSiIYhFMVpMZObkkJldQHFeJek5aXiJ4x7uAyDg9WIxmjCZLKSZrdjT0hjxRnDZFdLTrEQiCcszSZHvgu2Zzs0y4SMjqZEHbX7HzeZV3E1EHwVtSfE9TTSWyDKTpDE7V8Z2gMeSssbyTiTN48PhMCZt4qeuRnR0PnfcTGTE7w9itZohDpGIH2JRFLORCy3n2Lr5PbzuKH3DHpRsC1XTpvCVR9djisPObe+z5d33CFqtDIz4cBht/OmffJO5tTXE4xAyJd7fiKSLkQnChI+MpFaZpBqXjTepUZDP3vaM2JL5pKJp7Hniu4/9HYlECISCGM1mFDlxnqKxqOqkGIvFVCEiml3p6OjoXI/UsdUgX90ODwQCvP/+brbt2cW0hTNJy/4inZ2dZFjNeIeHOHbsGEfb2/GEInzx4Q0MDQ1BCAxmGBwZJj39o9tN6NxdJnxkRJDadVP87LO9HTIRuEUxEpcgFiMSjaKYEomscZLTX31+HxJgs9oSJXpjxCMRDIqiR0Z0dD6H3GwCaygUQsKAYiTZfiBu5K3fv8P/+Idn+cu//y+sWfcALsAQj0AUOi6289RP/hZrRjb/65lnyVTspFsUkKA/5MVqs2PmM7Ai/5zwmdlD0JbbCiO0iaSjRB6LKF0Lh8OEQqHx/lifgNTqmU/wWE0Ld0E0FiUcCQNcdZkkTiwaJeD3QzyeECKQbPr6Sf/o6Ojcs8TjY+XHRqMafY2GQsTCYQiFcVhtjI54MJpMJKzMSIwL0UQ7jFgsRpwouZnOxJb52LhhtdrH7TvpXJ8JLwq15bvavJGJEhER+StwbTLr54FgIIDJZBobLK7+3CjJxCQZA3FMsgKyQiwaRVZkLLKVsKit1/gs6OjofH4wII1FRyQ1InLNYwyMebHExsaMMFbbmGFjyIA34MWkyDht1jFXVUMijw2ZosISbBYLwwODBIJhTLIMMkRDMRSjRBQ9KDuRmPBi5Ho+IhNFiMC9YH71acTT1eeYrZZrfmvQPErrmqoeKwMYzSaMZtM1z9XR0fn8YBiTITczohtNFuIGUMcf2UAg7MNileg638blvDzyc7KJRcKEQhEaj59muNtNyZQpxMJhTHZj4vmKxODIMC49Z2RCMeHFiM5nl4kjGXV0dCYk123WmUzCsTUhQEzGqwuYaDxGWXkx58+d4efPPsszT3uQTUaGR0bIyMgAo4zP5yM9PYPAqAenw0YYCEUjuNKdGPgM5Sl8DtDFiI6Ojo7OhCXRnPRa+/nomKuz2WzmW9/6FuXl5VRUTaWzq4uhoSHcnmF+9atfkZ6enmiXwVg6STSKUVYIx6IYpc96ZPveQRcjOjo6OjoTlqTeNmO9qmQpYaFQUFBAcWkJK1eupLCkmDSXk8ppVWCAzq5uXn/9dbwjHsLhML5AAIvFgtWUsBaIxWKgi5EJgx6l0tHR0dGZsGgLA2KxGPKYgJBlmcudV7h8+TKjo6OkuZwJc7RgoorP7XaTl5eH2Wwm05WBzWJJqvhTDPr0N5HQz4aOjo6OzoQkteWHtmCgt7eXiooKyqaU0zvQn/ihAQxK4jEmk4n+gQEikQj9A+7ENk00hgT4/X6Mn/nig3sL+emnn356vD+Ejo6Ojo5OagJrLBYbEyCJNiDymDDp7etlz+69/Oxn/8S+vfvo7e3FYXeQnZlFJBrl8OEjvPraa2zduhWv18voiIfC4mIURcFstWA2GjGMvZ2eaD8x0CMjOjo6OjoTEm2+SCx21Wzx8uXL7Nu3D4PBwOoHHwSDgebmZqLEyXA5udLVyY4dO6itraW8vJyDBw8yMjiExWLBMFbBM+IZHYdvpHMjPjN28BMVYVMvQonRaFQNJYZCIYxGY5J9PVy9wRIlawqxWEx9vs/nGzP5Sf63jo6Ozj1H6uxzwzBFLOVvACnRjuJ6pLzOjSY5PSoycdAjI7eI6M4LCbERiURUBS8s60OhkNrJ12AwqK6touGf9jkWi0UVLVa9iZyOjo6OzucAPTJyGwiHw8iy/JFW8KlCRWSIy7JMJBIhEolgsVjU14tGo+r/dXR0dO5JbjUyoq+n7xn0M3mLCJFxIyHS3d0NJCIoIhJiNpsxGo3qcxRFwWg0qmVnkiQl9bzR0dHR0dG5l9EjI7cBbZ5IMBgkGo1itVrV3JBwOEx7ezsdHR14vV7S09MpLi5m0qRJhMNh0tPT1eeazeZr/q2jo6NzT3KLkZF4ynr6Y3NAbvr9dO42ugPrbUAIkVgsRiwWSxIi586d4/XXX2ffvn3Y7Xby8vIIjXWsdTgcbNiwgYqKCrKyspBlWe1IbDKZ1ARXHR0dHR2dexk9MnIbEAJCWxUTj8e5cOECv/nNbxgcHCQnJ4dFixZRWlrK5cuXOXHiBD09PeTk5DBlyhTmzp1LXl5e0uvpYkRHR+ee5jZHRm74Mno5zYRHn+lukUQTp8QNoc0baW1tZdeuXXi9Xh555BGWL18OQHt7O3a7naVLl2K32/mHf/gHfD4fpaWlqhgJh8OYTKYkt0EdHR2dew4hBuLcpDCQSAgSPd3xXkM/o7eIiGIEAgEgISQgYUX87//+71RVVbF8+XL15y0tLfzsZz9jcHCQ8vJyHn30UaxWK11dXWpJrza6opPInwkGg0k/0xogxeNxdYtMR0fnM8jHChHpun+0Lqof6ah60w/UGS/0yMgtIvI8jEYjAEajEZ/PR3t7O7W1tUyfPp3m5mZOnjyJoii0trbS39/P1q1b6e3txe/343A4OHPmDLNmzSI7O1s1QotEIphMpnH+huOPSOSNRqNq5ZKoOJJlWfVv0SIEih5d0tG519DX0Pciuhi5RQwGA6FQKEk0+P1+Ojo6KCsrw2w2s2PHDnbs2IHH46G/v5/m5mY6OjoYGRlhxowZ2O12jh49Snd3N5mZmWpkRBciJB3bSCSCLMtJeTRaMzktIlKiixEdHR2diY8uRm4DkiSp2zUCq9VKf38/ZrOZ+++/nxkzZhAOhzlw4AB79uyhpqaGlStXEg6H6e7uJicnR13x69szV9EKslTR4ff7k/xa4Ko9v8FgUKNVOjo6OjoTGz3edYvE43EURSEUCgGJFbnNZqOqqorz58/T3t5ORUUFCxcuZOnSpZSVleFyuVi6dCkrVqwgKyuLrq4uFi1axKRJk4BEBEA3PUugFWYiqdfn8xEKhbBarSiKgiRJ1wiV1EiJjo6Ojs7ERY+M3CJiFS7EQyQSwWq1Ul5eTkZGBh0dHXR1dZGfn686rwofkq6uLk6cOMGlS5f40pe+hMPhAJL73XzeEcc2FosRDAbp7u6mt7cXs9lMXl4edrsdi8Wi9vERkaXUpoQ6Ojo6OhMX3WfkNiCa4ZnNZjWpMhqNsmXLFhobG8nMzGTGjBnU19dz7tw5PvzwQ3XC7O/vJysri6eeegqHw6G7rl6Hzs5Ozpw5Q1dXF4FAgHA4TCgUIhQKUVJSQm5uLqWlpeTn56uiRE9g1dHR0fnsoEdGbgOhUAhFUZJs4QOBAOvXrycQCLBt2za6urro6OhAURRsNhtXrlzBbDbjdDp5+OGHycrKUiMAYnUfiUQ+93kP/f39HD58mB07duDz+ZgzZw5z584lGAzS0tLC5s2bqaioIBAIYDabKSgoULds9KiIjo6OzmeDCSdGhFeEmEzC4bDa3VaQ+rPrdbmNRqOqOBCP05aFwu3r/2I0GgkEAknvZbfbAViyZAl1dXWcPXuWkydPMjw8TG5uLrNnzyYrK4uampprrN+j0ejnLgFTCDGj0Ug8Hicajaql0Js3b2bOnDnMmjWL4uJiMjMzURSF6upqioqKGBgY4OzZsyiKQkZGhnrsdTGi83nn4wLf+j2iM1EYdzEiJt7ruZgC6oQcDAYJh8MoipIkOkKhEJIkqT+LxWL4/X7MZvM1pbGpr307hMjAwABZWVnYbLZrfhcIBMjNzSUvL4/8/HzKy8vp7e3FbrdTWVlJVlYW4XBY/Y7i+wlB4/P5rvu69xJaozdxfkSH49HRUYaGhhgaGqKyspKGhgYgUUVjMplwOBw88MADHD16lOPHj3Pu3Dnq6+ux2+1qjonYttHR0dHRmbiMuxi5Edo9f5/Ph9FoVBM8I5EIQ0NDSJJEZ2cnmZmZ2Gw24vE4NptNXRlre8VAsrNpPB6/LUmiWVlZ6r+DwSDxeFwVRlrRZLVaqaiooKioSHUU7e3tJTc3V32MyDURRl73uhCBa31atDk3ly5doqmpibq6OubOnQtAT0+PGjWKRCKEw2Hy8/OZNGkSHo8Ht9tNbm7uNdE0HR2da0m1JNDRGS/GXYzcaMIQgkEIjFgshtvtJj09HUVRaG9v54033uDSpUtIksTMmTN55JFHcLlcBINBAoEA6enpwFWLdhGBEE3tbteNKKIz2kiLmFRF7kd3dzd79+5l27ZtDAwM0NDQwMqVK9VqECFAtIZet2sbaaKjLWMWJbuBQIDLly/T2trKd7/7XdLS0nj22We5ePEiWVlZeL1egsEgWVlZfPWrX6W+vp4TJ07Q29tLQUEB6enpummcjs7HoG/j6EwUxl2MCIQ4EOJEhO0DgQAWiwVJkrDb7TQ2NrJ//36am5sZHh4mJyeH3t5ePvjgA86fP8/y5ctZsmQJOTk5Sa8fiUSAq4Lkdq6atZOeEDji9T0eDzt27OD999+nq6sLs9lMVlYWFy9e5IUXXqCyspKHHnqIadOmYTAYCAaDqsuoPhCQtFXT399Pb28vgUCAkZERgsEgdrsdv9+P3+8nHA6r0RLRwFA/hjo6NyY1OizEiV4ar3O3mRClvbFYTM0d0UYGBMPDw7jdbtra2njvvfc4fvw406ZNY/369cyePRuPx8PevXvZtGkTPT09zJs3jwcffJCpU6eqRmJAUmLkncDj8WC325EkiYGBARobG9m9ezfNzc2EQiEefPBBvvrVr5KWlsa7777La6+9pgqqhoYGli1bRnFx8R35bBOZG23TNDc3s2fPHvr7+/nBD35AWloao6OjhMNhXC6XWt7b3d3NH//4R+LxOI8//jiVlZW6ENHRQY986Hx2kJ9++umnx/MDaA2qxFYFJCalYDDI6OgoZ8+e5eWXX+all15ClmW+973v8c1vfpOysjLsdjvp6elMnz6d1atXMzg4yO9+9zsOHjyI0WhUk1kdDgcGg0GNXIhchVuNkLjdbiARcRE+I01NTbzxxhts3ryZpqYmli5dyl//9V/zwAMPYDabCQQCVFZWsn79eux2OydPnuTtt9+mu7sbl8ulbi/drvWSQw8AACAASURBVLyWiYw2GgYkJTJbrVZ6enr4/e9/T0ZGBtOnT8dkMiFJkproazKZaGtro7GxkdLSUhYuXIjFYtEHWR2dmyASiSSNwaALFJ3xYdzFiBAG2pVsLBbD6/Xi8Xj4x3/8R/74xz/idrv5yle+wlNPPUVpaak6WYVCITUvQ1EUFi1axPr16wmFQrz44otcuHABg8FAbm6umlAqJj+tL8inxWq1qp/d4/GwceNG/uVf/oXTp09TXl7O3/zN37B06VLy8/OBq5OvMEorKZ3MkmVLyMrMZPPmzfzhld8zPDRI+eQyMrOyr/OOMYhHgSgQByTiBogBcSJIRAED8biBmCHxiES37DAQJz7WAcAgxp7xHncMBjAYiMZjRGNRZElWI1hie665+QxpaelYrWYcDjsmk5FYLMrIyDAHDh2gta2FSDRC7Yw6JpeVEY1GPxdCTkfnVvF6vWr7iVTnYl2U6NxN7to2jRAM2iqHWCxGKBRSRUIoFMJgMDA4OMjGjRv57W9/S2ZmJkuWLGHVqlVUVFQklWoGAgHOnDnDkSNHmDJlCkuXLlVvotHRUQ4cOMDu3bs5e/YsJpOJhx56iFWrVuFyuZImq2AwSCQSwWazJQkiSZLUTrHiZ4AqPsRjfD4fu3bt4tVXX+XKlSvMnj2b1atXU1VVRV5e3o2PCUJEgN/j4fy5s2ze9Ab79u5hUn4B9y9dxkPrHiUvL5H/Eo+GiQR8mKwKeD1gcwJWojIEiWHAh5UYxKxEMBIFkBKJQXJoAIwWIgY7kTAYgiHMFhlkedwEifj+Wq7Kh8RvRoaHOX7iKAcPHGb7jveZMrmcr371q/T397N77x6ONZ1ixsx6vrD6QeY3LMBmsuD3+TAazRiVFJ8Ww9X3Fa9v0Nsz6UxwtOX/fr8fRVE+0oModZElFnfhcBi/309PTw9tbW1cuXKFM2fOMDAwgM/no7y8HFmWmTx5Mt/4xjdwuVy3ZcGmwzU+UqKnmRbt/KL9WeqiSuRXAmq0X5C6PS2KIEQ+nZg/R0dH1erUicJdzRlJrV4RN5novhoOh9m+fTt//OMfGR0dpaamhqVLl1JaWkpxcXFSoqjwkejs7ORXv/oVFy5cYObMmSxatIjFixcDiVyTQCDA/v37VRfUqqoqVq5cSV1dHU6nk1AopJYCw1U/E9FHRiAqZsQFFI/HGR0dZc+ePRw+fJjW1lby8vKYO3cuNTU1FBYW4nQ6P/p4AIFwotW91SghGWKMuAc4dOgAe/bsp7m1jfSMbL6wbj3z5sxmUl4WxMMQC4JnEBQHGLMYiYLBFmEk0EmBxYYh7iQUNzLshbQ0MAJytB8MRiKSk1gcTDGAGEjSuIsREb3RIqliIUYoHFK9RAI+H9FolEAggM1hJ7+0mLLKKZSVlGEzW7AYrcgYMMQlAn4/Fq3PiEH7vonXl3UxojPB0Sa1a/GN3QuKoqiTTCQSob29ndbWVnp7e2lvb8ftdjMwMEAkEsHpdJKbm0tGRgZms1ndrs7NzSUWi3HkyBEuX77MggUL+JM/+RPVeiDVD0oXKTfPzVpJXC9pWFhcpBZGpJJ6fkQeZqpoFTYZE9FQ846LEa2qh8SNBcmGY8FgkB07dvDyyy+romLNmjVUVVUxefJk9XGpCaiRSIRIJML27ds5cOAAXV1dAGr+SHV1NdFoFJ/PR0dHBwcPHmT//v2MjIxQX1/PwoULaWhowGQyqeLGbDYnWbqLHA8gSVUePXqUpqYmjhw5QiAQYPLkyaxdu5aGhoabDm9qIwMyQDQEkoFo0M/Zs+c5duo072//ENlkpqZqKl/+4uNkOiw07tvFpldf4dKlXrAUc2l4kJDNw6D7MhuWrWBaZQMPPfFdrGkQjYIpHsFsHAEU/JF0ZGVMjISDYDaPuxjRkhoZCQS8WC1jA204jMEAly5dwjc6Sm5BPiHiZGfnYUBCAuJxUAwShjiEgkFM2tLoJDGSQB9OdT4riEnJ6/XS09PDyMgI3d3ddHZ20tHRgcfjwWAwYLFYSEtLw2azMTQ0hN/vJxgMYjKZyMnJoaSkRF0sZWZmEg6HKSkpwefzcezYMTZt2sTly5d56qmnWLRoESaTiWg0SiQSwWw2E4/HCQaDST5KOtfnRkJEiAsRDYEbb40Jd2ptgUcsFiMcDqsL9NTnCS+rvr4+PB4PpaWluFwuAoEAkiSpc95E2sq+42LkRgpaJKju3buXI0eOcOLECUwmE/Pnz2fp0qVUVVUhSdI1fh3abR5tpCUQCLB79262bNlCS0sLZWVl6mtlZGTgcDjw+/3s27ePHTt20NPTg81mY8aMGdTW1jJjxoykJmva1xU3XTgc5vz58xw5coRTp07R09NDaWkp8+bNY9GiRWRkZKjfTZzoj1o9xAGPL4jdZr4qRuIxkA2AzOiol1NN5zh89BixcIjHHllLcXE+547s548vvcjGjW/ji2Wx7itfxmseJh7zEO/rZeMf3uFL3/w7/stPfkRWNhiJI+GGuBFPKB2TGcwxiAf8GKzWcRUjkCxIUsVIOBwgFAphlJWEgB37rJ6hIdIyMohgIIqEYey5BiRi0QgKEobUG00XIzqfMcQC6eLFixw4cIChoSF1u0WWZUZGRnC73aoJpMvloqioiNLSUvLy8sjOzsZoNGKxWLBYLKoztSzLag+s1Alpz549vPjii+Tk5PD4449TV1eX1HtLlM/r7sYfT+pugFhQQ3LBhiAWi6lJxZIk3TCCEYslIuodHR34fD7cbje9vb309/fj8/nU+UfYSBQWFvLAAw8kVWtONB+ru7JNo1VxIix46tQpTp8+zfbt2xkeHmbq1Kl8+ctfpr6+nlgspu5paZ+Xiug/I9RhOBymp6eHffv28eGHH9LZ2UlFRQULFixg3rx55ObmIssyAwMD7Nmzh507d+J2uykqKmLOnDk0NDRQWFiovhZc9RDp7u7m6NGj7N+/n56eHvLz85k6dSr33XcfZWVl6mfy+/3qTfpxoUztpCjF4xjikbEJMwbIRCJR/MEoBsVIJBjAKMex280QCxLu6+InP/l7RkIu/p/nfo7BEUPGx8ClZv7rf/6/2Lm/l2f/6Tkefmw2FjmGbBiESJzhcDZGE9jE4TQwIcRIqj43qEcmRjQSQVYUTp86xX/84RVGRkYoKirisSefxJruJGIwYFKMOKw2TLIxIUriJMIk2utGFyM6n0EGBwd566232LJlCwBlZWXk5eWRkZGhJuZnZGTgcrnUpG9FSYh3EenVCg7tBClaThw7doxAIMCCBQsIBAJs2rSJnTt3kpOTw7p161QHZIG+TfPJ0W633GxEYnBwEEgsivv7++np6WFwcFD1URoeHsbn89Hf309XVxdDQ0MYjUZyc3PJzs5m8uTJXLx4kY6ODiorK3niiScoLS0FJt45vOOmZ0Lhmc1m/H4/ra2tnD59mlOnTnHp0iXKysp44oknmDVrFmlpaXi9Xmw2G+np6arQuN4emjbqEAqFCAaDOBwOioqKePLJJyksLOTkyZNs27aNkZERLly4wKxZs5g5cybZ2dmsWrWKqqoqmpubaWxsZOPGjTQ2NnL//fdTV1enCpcrV65w7NgxDh8+TF9fH2lpaSxYsIDZs2czderUpORb4FOvFiKRCArRxNwZj4IsoRiNmFGQjTKSxUgo4CPo8WC2mzCaTHi9XsyOSXR395FbkUGEIMUlZfz4xz/mrQe/x5mzp1nln401bWz6VYxYFAiFYcQXJN1hSp6s7zIGrgqSG+EdHQWgq6uLn/3sZ+zfu4f6+nrC4TA///nP8QSiPPTwelauWIFRVojFY0iGq/um0gS62XR0Pg3t7e10dnZSWlpKbW0t9fX1uFwuFEUhMzMzKZctNVdAG4rXrsrF40XLiUOHDtHW1oYsyzQ0NPDYY48xNDTEtm3bcDqdWK1Wqqur1TFXluVrtuB1riU1MpI6+YuFt8/nIxwO4/F4GBwcVLdTent7gYRo7O7uVrfjjEYjdrudoqIi1dpCpBw4HA6ys7PJyMjA5/MxY8YMNm3axL59+7Db7Tz22GPq/DaRuONiJBKJYDQaGR4e5siRIxw8eJCenh4cDgezZ89m7dq16oHTPkfbAVcg9t+0e2vicaLzLSRutIULFzJr1iwWL17M22+/zaFDh7hw4QKXLl1i2rRpTJ48merqavLy8iguLubYsWM0Nzfz5ptvcuzYMebPn09tbS1vvPEGra2tjIyMUFlZyeLFi6mpqUlKTk1NMBOhtpsxVxtwD5OWlobVaIT42PQcB6JR4hgwGhVG/SEUA1gtFjDLEPLCmMgTnWplZEBhoO8K+/bsxawYMSlG0hxgwMCV1lb6BkaIOKrp6R1B8g8wc3ol+cUFt3aCbwPaNUKqNLKPZXz/2y//Xy5daOfZZ59l9Re+wMiAm58/90uO7T7A8PAoRlkce4gZEjtdkiyD4cZZKTo6E52RkREOHDiA2+1myZIlLF++XBUQYuta/FusuLUdy7Vocw60uQwjIyNYLBYuXbrEq6++SlZWFuXl5cyfPx+3283Fixf58MMPsdlsFBcXJ41zOjePVpREIhE158ftduN2uxkeHqa7u5tLly4xNDREPB6npKSE9PR0nE6n2nDVbDaTkZFBeno6VquVjIwMcnJySEtLA66mQITDYdX0MxQKEQgEaGpqUitUP6rSczy442LEaDTS2dnJhx9+yMGDBxkdHaW6upolS5Ywffp0NaNbbOVoJ3XtnlaqCBHlUVqPEkVRkm6QWCzGtGnTmDRpEg0NDezevZtdu3Zx4sQJ5syZw/Tp0ykvL2fmzJmUlpaqYunixYucP39eXVUUFBSwbNky5s+fr2aXa8WG+IxiVSIShG6GrMyroibk96PIEpJJAUUmFo0hSWOGaooBiCUyUqNRsFgIhyO0NJ3h5InT9EY6yHIpeC+08fJLv+Pxxx7lq1/9MkThwuUWXnnxRXZ+uJ+gtRKPN05pjp2vfelRHi955NZO8B1mdGwVcObMGcrLy1mwYAGjw8OkZ2Twox/9iPtXNOHKyWVkJEC6w5I4fjAWckl4rujofFaJRqPqajg/Px+bzaauop1OZ1IERIyN2mhF6vaMQDuWpqen8+STT3LlyhW2b9/Oe++9x/r166mvr8disfD888/T1NRETU0NaWlpZGRkoCjKhEp+nKjcqJhheHiYvr4+Nm/eTCAQwGAwYLfbMZvNlJWVIcsyNpuNtLQ0cnJyKC4uJicnB5vNpi7ARc6PEBp9fX2qK7UQIxUVFRiNRhoaGohEIrzyyiscOHCAgoICXC7XhOrfdVd609hsNlpbWzl58iQ/+MEPuO+++0hLS0vKxvb7/djtdoLBoDrJay/21JN6oxCT9jl2u51wOExmZiaLFy+moKCAvXv3cvr0afbt26duy1RWVlJTU8Pq1aspKyuju7ubH/7whzgcDv7iL/6C2tpapk2blnSTXy/qIfrpfFpMVivajAZZUQiFoxiNmu9qMCQqYOKJ5KZTTSf5s7/4Pj3BdlxOCWcwgMuax0/+5m9JSwNFhvfee5fNm9/kcGMHi9ZP41+f/xdmV2USDUSv+zm0aEWXNvIEV1dGIiysDRHfbAj3mls1xYzN4UjDPzrK/HnzeP7556mvm8E3vvENiMZQDBINDQ3EJDBKMOoJ4kxLCMP+vj6yc0VH5RixaByDJH3iXalQKHTNwKsNfYtJIPX61JbpafOIwuGwusUYiUTU19KuWEW3ap3PF9p7Rlwbx48fx2w2U15eri6EvF4v7733HpWVlTQ0NADX9pi5Hh81MTqdTr797W/T2dnJBx98QEFBARaLhaqqKjZs2MCWLVt46aWX+Na3vsX8+fPp7OykoKAg6bMajUYMBsMn6gt1M9Uk2sd91szYRKsLbaQqEAjg9XrZs2cPx44dY8mSJWRlZVFaWkpVVZU6hgofEK2Jo8i5HBkZwev10t/fj9/vZ2BggK6uLrWE226343A4cLlcah7kjBkzCIVC/OY3v+HXv/41NpuNWbNmqYEAo9GYNK7BzV1Xt4u74sAaDoc5efIkIyMjrFmzhilTpqAoiqrgjEajqvS0N+TtGJDFBCnLMpmZmdTX11NYWIjH46G1tVX9A1BQUEBeXh6TJk3iwIEDTJo0ie985zuUlZWpn0kktmpNz24FMfeOXQKan0pgMCDJMsMeH7FoFJNRJh4KEPOOIAX9bNu2A0taAT//5S/587/+Hn/+3W/yhcVLOH2iif/50+fw+Q3Uz6xlckkuVmMEb3CUFeu+wkMPLUQG4tE4ivLRn198v3A4rFqwi+Mq3GTF5CluFHE+bwnVIjaOUZbJnzSJ5uZm/vF//TM7d3xAVWUlhcVlyCYlYeIKmIwKPm8Qk1EZ846JEQj4AJAV49ggZkg60h939lIz3rVJaNo/4mfafXlJkhgdHcXv99Pc3Izf7yc7O1tNPBOrHBFaF8dR/N/r9U6obHedO4d2shH/DwaD7N69m97eXu677z5qa2tVZ+mWlhYqKiooKSm5pfeNRqNYrVZVVBcWFtLZ2UlTUxNOp5Ps7GwKCwsxGo20tLTQ1NREfn4+lZWVeDwetTJH9JPSRqpFpPvjvrfgo4SG1oxS+/+Jjna8FN9PURQ6OjrYsmULhYWFfOMb36ChoUEVgFarFdNYTqCokmltbeXYsWMcPHiQxsZGmpubuXjxIpcuXaK1tZWzZ89y7tw5urq6iEajpKWl4XK5qKmpUbf1RFXqyMgI/f39XLlyhby8PHJzc5Mas4royt2OmtzxyIi2RtrpdOJyuYCEOjx58iTxeJx58+apJ03rUnc7xIgQESLiIssyU6dOVRNR33zzTXp6ejh58iQlJSVUVlZiNptVl0Nh4w6o3WDvdkddi8WCxSgBMQxmM7LsgNFEiV92diGVFUVIdgjH+8mtruZv//e/Yd0Tf83uXTt4aO0CFiyoZPLkyYyMjCT2iknIHaNZvq7hWCrBYDBpoAgEAgmjNqsVv99PY2MjxcXFFBcXJ03Wn0ispWayav4fi0YpLy/nmWeewawovPrqa3zpS19i7oL7+d/+j//BnHkzkKWEf1ssNpaTG0+s2CxJ0abEJB9HwiDf/PlLdTjUMjQ0REZGhtpxGRLbdkNDQ7S1tXHo0CG6u7vp6+vDZrMxb948Vq9ejdPpxOv1qgJFXOva1xB7wDr3NsIDREzgRqOReDxOd3c3TU1NRCIRqqqqUBSF7u5uduzYQWlpqRqZuBWEAI5GozgcDubOnUtHRwevvvoq27dvJycnh5kzZzJz5kx6enp4++23efnll8nNzU1qcSEWJtpx8ZMs1LQiTPsagUBA7UclTL9ETt5HmYBNJLxeL3a7nXg8ri7qrly5Qm9vL3a7Xf0OAwMDXL58GY/HQywWw+Px4PP5CAaDDA0N0dXVRU9Pj+p/Zbfbqauro6ysjIULF5KdnY3NZsNkMmEymTAajUmCQpZlSkpKWLFiBcFgkA8//JD8/Hyys7PJyclRbSxMJtPHNli8E9xxMSIuUOERIujo6GD79u1IksS8efOAxIWoDVN+khKoGyEiL8KsJxwOYzAYKCoqoqioiIqKCo4fP44sy2RnZ6ufQySHCcc6cTOIHBe4O+o8GAwTCIWxGG1EIxEM4QCSKRE18fl8SI7E1kMckA0ypjQ7NQ0NZGVlceDAPpqbz7BgQSWRYEg9DjHAHwLCQZz2j155i3MizoM4j2KLra2tjXfeeYfZs2dTUlKi3nTxeDzhkjqmyj81kQiSyUQ0GKS8ooKf/vSnfP3rX+f5559n01tv0T0U5i//83/l0UeWY4iTKH0GgoEAGCIoRknzUhFiMZCVmx/AxOBxo9Ly9PT0pK0Vg8HA5cuX2bZtG9u2bUOSJMrKypgzZw4XLlzgxRdf5Pjx4zz++OPk5ORQVFQEoO79aiMh47E60bn7aIW+SPgPhUKcPn0av99PWVkZmZmZjI6Ocv78ecxmM7W1tUmWAp8WMd5qt1Tvv/9+4vE4W7duZdu2bWrVxsqVK4nFYrz++uu88MIL/NVf/ZVqvxCPx9VrV0SPb2qb9jr3lVaQXM9Y7Va3w+8mWtt3MS5evnyZs2fPkp+fz1e+8hWyshLbyT09PezYsYOdO3eqDV5dLhfZ2dkUFRVRV1eHy+XC5XKRlZVFeno6Pp9PbRarzV2Eq9eVOB+KoqAoCtOnT8fv9zM0NMThw4fJz89n0aJFSfbwovr1bnrJ3JWcEWGYoy0xC4VCahM7McFpO7hezxDm0763wGAwqDeImECcTiezZ89Osn83GAyqQ534LNe7+O+Gg53ZbEQxj21bKQrIFogFGR0exmq1MuT3E40m/DJMmCAW4ufP/E/OnzvL6tXrWLFsOUTDDA4N4HDYCIRDRAGbCUymj98C0A6UPp8PRVEwmUyEw2H6+vo4ceIELS0tFBYW0t/fr66w7Hb7zQmRjxPgY+GOtvMt5OXlkZOTw+p166icUkH97Pv41W9f57nnnmflimW4nAbksdNhMisYJIVRT6JSQDGaxq4FSY2ThEJxrKaPvsa0QkQ4/ooIm1Ysy7LM0NAQ77//Plu2bGF4eJji4mIeeugh6urqsNlsXLx4kZKSEjZv3syRI0dYvnw5GzZsUAcWrRARGfG6GLn30SahCoaGhjh58iRZWVksXboUu92uRtqmTJlCbW3tbVsMaUWv2+0mOzubhx56iO7ubnbt2oXRaOSJJ56gqKiIJUuW0NfXR2NjI//2b//Gd77znaQInrg/bvazaSMiWrQ5V+JeEIJfuzia6KIkFosliQTRZfz06dNUV1eTm5tLOBzG5/ORkZHBnDlzcDgcqm2/0+kkLS1NHSPE/CjydEQekXh90d9NO5ZovbrEjkNdXR0Gg4EXXniBnTt3YrFYWLVqFXC1cORum9rdFTESiUQIBoNJpblpaWlqZ1YhVsR+u0iGuh1o9+y0oT2RRCicDLXbOUKoiOdfzyVPWyZ3pxkYGMKVnoZsiELIz4Fd77Nt65t88MEORsJ5fPvb32eEbnKzZEZam9n1/glWrPwKf/WXP2RSfjYffriVP/zhD2zf0UT76G9xZpfy9Q0rkOWPN/0SYWNxU4mQ7q5du9i6dStHjhxh//79tLS0qIp+2bJlPPLII+Tm5t56ZESSGHG72bZtGxUVFaxa+xAAJSUl/Lf/9t/oGgjz+//YyMjwKFkZaYTD0N15hbwcJ1abBYdmoExcXwkDNQCj8eMHTO25FzeyOO9CSA8NDXHq1Cnef/99jh8/jtPp5NFHH2X58uVq8lg8Hqe2tlb989prr/Huu+9y4MABlixZwtq1a5kyZQpwNZqnb9Pc+2ijANoxpaOjg+7ubsrLy5k+fToAfX19NDU1cf/991NaWnpbHDTFBAmJcTozMxNImD2uXbsWt9vN7t27yc3NZd26dWRnZ7NmzRqGhoZ48803qaqqYsmSJdhsNsLhMF6vV7Vp+CTN2FIbvmnFiKgsSSU12j4REfOPNv/r4sWLeL1esrOz1fJaIToyMjKoq6sjIyNDzcERXG8LrK+vD4vFouaf3SiSJK4r0TDPbDZTV1fHE088we9//3s1f0VUuF6vT86d5o7PpiKHQIgMUZEhVJf24CmKorazFvumt3owhoaGcDgc6ope+7kkSbpG/Yn3FIlZomeNCA1qkxbvFpmZGSiGhF8IshWz2YzT6WTNmjWYM2oZikSRQ0Fycsxkhvys+Mkqvvnd/44rz0owEsNut7Ns2TJqZs1HyZ9HXl7eTffHC4VCaqhRazIXiUQwmUxUVVXR3d2t3ljxeJycnJybj4zcCDEuhUKkuzLp7+9n+/btFBcWUl1dDYDH48FstjJjRj1gIBiEzs4uDu7fg987SHq6g9WrV5ExlqcEiZsxjoKk3Jzfm7YdgVaIxONxdY93//79bN++Hb/fz8qVK/niF7+YVGkwNDSkDhaRSIQFCxYwd+5c/uM//oMPPviAgwcP0tLSwsKFC1m8eLEqYHTufVInG6PRSFdXF+3t7RiNRkpKSrBarbjdbjo7OwkEAuTl5ZGXl6eOpbeCmHRE0rXA7/dTUlLChg0b6OvrY/fu3WoUubS0lBUrVtDd3c3GjRtRFIUVK1aorq+CT5rPIQSJVpSIJFgh/LXO2HdrMXg7EELz/PnztLW1MWXKFKZNm6ZGkkT6gMlkUhu3hkIhrFZr0vwpFtFiPsrJyVHf40ZW89qFvVhMip8vW7aM7u5u3n77bV555RW+9rWvUVVVpaYp3M3I7B0/m8J91Wg0JvmAiARHIT7EBSgECSSSl241VKTtFyO2isSJEid3dHQUq9WqKksR7orH40nbNdqL/2Y7MX4iDFKiN42mxiMYDGMe26bp7+sjOzuTOUuWMWfePDA78Y+aMaXDcCSEzRTGQhiiZqJ+KwYJrGaJ2Q3zqaspQ7Fn4COdIT+YDTdn/yVuDNELQQi4Bx98kAcffJB9+/aRlpbGzJkz+drXvqY+Vgwan/5YjP1tstDf04nVnoZsMvLSyy8DCUvsE6fPc6ati//01FNMLnUQDECazYq7f4Ctb7/JpLwsPJ4RZs6cSX39TBRjIvQonOLD4Riy6aOPgnbVKgZXv9/P2bNnaWpqYufOnarV8ne/+12mT59OOBxWE1tF1dj27dtxu93MnTuX2tpaFEXhi1/8IuvXr+ell17ijTfeoL29nYsXL7J48WKmTZumJnvr3NuInAsx8Pf29qpuz7W1tUiSRFdXl5oEnZ6eftveO3V7XIzFYiExdepUNmzYwHPPPcebb75JZmYmCxYsYOHChQwMDPD000+TlZVFUVER1dXValL79RZ6n4aLFy8yNDTEpUuXaG9vZ3R0lNzcXGbOnMnUqVPVSM5ERxzPkydP0tHRwZo1a6ivr08q2BALc7EAkmVZrU5MnXu0W3piDrpRtF4rCrUde4Xg2LBhA52dnWzatImsrCyysrLGxYPkjpf2ivyQAwcO4PV6WbhwIS6XpIEUEwAAIABJREFUi/7+fvbs2YPFYuHBBx9UyxlFSEnbc+Z2oFWUqdENsQepLb964403MBgMrF279pr23UI43aoQMaT8gbEaVYM0tmyXUBRZ/b3N7kj83CCD0QKSgtFswCCBWZYxImHACAYZySRhkMULS0gmK2BCQsZuTGzPqL++mc96g2hQS0sL7777Lvn5+WoisuCmjs+1ByH5FwYDoUiY6ppalq1YTiAcZtfevezcs4doLMb3f/DnLFsyP9FsUAaH3cL8+Q1MnVpJT28vG9/YxOXLVxj1+rBa7aSlpY2JUVBkg+qeqy3P1aK9JgwGA11dXWzdupWXX36Zt99+mxkzZvC1r32Nb33rWxQUFKj7s2JgicVi6h771q1b2b9/P+FwmJycHLWMb86cOdx33334fD727t3LiRMn8Hg8hMPhpEFBiHftxCH2jrU/E8c9EAiM++pRtEm43rVwOyKft4rW10hEQeHqJK39jEJgi+/i9/uTBnb4dGFtcW2J1/3ggw946623mDt3LsuWLUOWZU6cOMFbb73FwoULeeyxx5K6l98Kqfd1anJoPB4nOzsbp9PJmTNnaGlpobS0lNzcXIqLiyksLGTjxo243W5WrlxJMBhUy4UTkUtzUgsPQSwWIxAIMDo6qjqRnjt3juPHj3PkyBGOHDnCsWPHOHLkiOoLdejQIc6cOUNjYyPt7e3E43Hq6uoYHBxUhY+45ifCtQ9XIzuRSAS3283Ro0dxu92q0WZqFSlcvb6EIEm9plJtBT4tYoEVjUYpLS0lHA7z3nvvYTKZmD17tioqte/j9XrvWALx+J+tCcB4DorXvuvHnWQpIVY0L5Do8Qvq6bzmRSUgET693YVwTqeTOXPmUFFRcc3E86nKs69zGpwZmWS4Er+YXF7B4088CSS2+LTJd6GgX20NMHv2bHJzc1m9eg2vv/46L774W44fP8mDDz5IRUUFOTk5WK2JLa9U4zLRNVP4pXi9XrxeL+fPn+cPf/gDu3btYtasWTzzzDO4XC4mT56srnxSPUckSaK0tJSvf/3rzJo1i40bN/LCCy+wb98+Hn74Yerr60lPT2fy5Mn8+Mc/Zvny5bz++uts3bqVzZs3s27dOubMmcOcOXPUQcDv9yf5O2jD2tow7URo8S7OjQgzQ3I4frwTdLXbCtoqMbh2ok7NY9M+99OOH6nR1aGhIQYGBpg0aRIlJSUoikJ/fz+dnZ1kZWVRXFycZEx1p3MmJEnCbrfT0NBAb28vjY2NvPbaa6xdu5b6+npWrVpFX18fb7/9Nr/4xS/4/ve/r5a2a6PSo6OjDA8P4/F4CAQC6nXa0dGB2+3mwoULNDc309HRQSQSURv/rVixgvLyclauXElubi5Wq5W2tjZ27tzJxo0bycrKYs2aNeoq32KxJHVaH29Evl08HqetrY3m5mZyc3OprKycEGXJPp8Pi8VCSUkJjz76KENDQ7z77rs4HA42bNigPk5sJ9ntdvU+vtmWJzeLLkZ0bolZs2apPRNEdOl2DpBer1d1dhSvrY06iMlMlBaK91YURTWr+7M/+zNOnjzJ+++/zy9+8QtqampYtWoVM2bMwOVyJa10RbhUm9Dc3NzMtm3bOHbsGOnp6fzoRz9i7ty55ObmqmV5Aq1xlfhbkiTVBXjq1Kns27eP9957j2eeeYaFCxeycuVK7r//ftURsbS0lEOHDrF37162b9/OuXPnOHPmDHPnzqW8vByr1Uo0GlUHXe0KPlWcTAS0YeXUSovx7m8iIrLaEky4GhETpd1A0uNuxmH0ZhY5qW67bW1tXLlyhcrKSqZNm4Ysy7S3t9PS0kJRURFVVVXq574bCZziGsvOzmbp0qV4vV52796N0WikpqYGRVF4+OGHOXnyJL/73e+orq5m7ty5tLe343K5uHTpktpxtq2tjXPnznHlyhW8Xi8A8+YlcthqamrUqiFRTZKWlqZGjES0UXhliH5nb7zxBqWlpVRWVqr3bGr+y3gTDoeJxWKcPXuWy5cv89hjj1FaWnpbcn5uFa2grqys5NFHH+Wf//mf2bRpE2VlZdTX16ul5toIMtz+e/euObDu378fr9fLggULcLlcDA8P8+GHH2I2m1m9ejWQvEq47fkYH4F2JSv+3rRpEwaDgXXr1t1w4BnvEPNEwGAwkJ6erh6LQCBwQ2+ZT4M2AqDN9xHvJcptteXXIucnFovhcrnIzMykuLhYbZ3d0tJCc3Mzly5dUjP1rVarahIk8ojOnz/PG2+8wZYtW2htbWXGjBk8+eSTapKpiIaIxDptJ2mBsJOHRNOzrKwsqqurKS8vx2AwcP78eU6ePMnp06cByM/Px+l0MmnSJKqqqpAkif7+fk6dOkV3dzcmk4msrCzVmE+cAyHUxJ+JUmkg8iG05dBaUkPOd/uP+AxwbfsJ8XPxuVPLuW90/2uTMG9GjGhdjnft2sXZs2dZuHAhDQ0NBAIB9u/fz7Fjx9TtPPHZ7kZkRLsKFv4WPT09tLe3MzQ0RENDA+np6UybNo2DBw+ydetWDh8+TGNjIy+++CLnzp3j8uXL6pZjZWUl9913H2vWrGHt2rU0NDQwZ84cNQeksLCQzMxMtV1IWlqa6kgqqjJFx1pFUdStnNraWtWLRVTwiAl0PBG5dsPDw+zYsYNQKMSaNWuYNGlS0pbreCG2IwcHBzGbzRQWFiJJEi0tLezbt4/p06eTk5OTtDWjbZFxO+dAXYxwrRgBdDFyk4jIhchf0Nb/347zJ9xeU3M34GoyloicQHLZtbb6R3TArKmpISsri97eXk6dOkVzczPDw4nOySIZ7sKFC7z33nts2bKFM2fOkJeXx5o1a1i3bh1Tp05Vq6y03y9ViGiTpQVms1n1THA6nSxYsICMjAxCoRCtra20t7czODhIPB4nPT2dSZMmUVdXR05ODvF4nJ6eHpqammhtbSUWi5GZmalGGrQ5T8CEGOgE1/NqmQj5InDVx0I7BogV6/WuYfF4EXrX/jyVmxnDtI+5fPkyu3btIhgMsnz5cvLy8rhy5YratXfp0qWUlJQknds7fQyFyBeeN+Ka6+7upquri5kzZ+J2uykuLqanp4ezZ89is9lYsmQJFRUV1NbWUlNTw/Tp05k+fTo1NTVMnTqVyZMnU1hYSGFhIRkZGWpUUzhfi/tXjCtiQSIEodVqJS0tjdHRUXbt2sXo6ChlZWVkZ2erQk0rHMcLcX6ampo4cuQIVVVVLFiwAOCu+3jcCFE1I45tfn4+kUiEQ4cOEY/HycvLU8dGce3fCRdyfZvmOkyEQfKzgqi2MRgMSVsmt4vr7f2mNuYSiGiI9jlut5vMzEzV4thsNrNw4UIKCgo4ffo0e/fu5ejRo1y8eJEpU6aoYfGuri5isRjr1q1j7ty5VFRUXOMvI1ZhqQNeauhdGDaJii2r1UowGCQSibBo0SLmzp3L8ePHeeedd3jnnXdob29n0aJFlJeXM3nyZObMmcOUKVM4evQoO3fupLGxkZaWFvbu3cvjjz9OeXm5elzEORjvQVigPQ5ilZ163sab1H1vEVkaGRlRBaQsy2pIW/udRETsettzN4M22bi5uZn+/n7Ky8vV0t1z584xPDzMlClTrin5vpvHUPiIGI1GqquricfjDA8Pk5OToy4W+vv7mTlzJkuXLmXx4sXIsozdblcXEKni+KOiRyK6KbYhxXaZdlFSUFDAAw88gMfjYdOmTbhcLn7wgx8AE+f6h8T2b1NTE9FolJqaGhwOB8FgUB07xxNR+SiivNFoFKfTyYoVK+jv7+fw4cPYbDYef/xxdUs6terndqGLEZ3bgpiAY7EYPp8Ph8PByMjILZchpjbG0ooBuFoNIX4uHicGsMzMTHU7x+FwYDabCYfDlJSUMG3aNKZMmcLhw4c5cOAAjY2NWCwWiouLmTVrFlOmTGHOnDnq64n8gv7+frW9t4iAiLyI6w26Ikl2cHAQWZZVt1Ux0UmSxKJFi5g+fTrbt2/n3Xffpa2tjerqaubNm0d5eTllZWUsX76cyZMnc+zYMU6cOMH58+d59dVXeeKJJ9RtH8FEyhsRk5W2Kk1MNrfL3PDTIqr2xPUihFJfXx9tbW10dnaqW5FFRUUUFBSovkXi+eJYa8/7JxUKfr+fc+fOEQqFqK+vx+VyMTAwwJkzZwiHw8yaNYv8/PykCeBuRJe0SYpCDDidTrVyTvz+zJkzbNu2jfXr17N48WKysrKSPHq098eNRJtYTEhSoiO5xWJRo62p9grC+6myspLHHnuMtrY2Tpw4wQcffKBGEycKV65coa2tjYyMDIqLi5Ny0sYbrSFaLBbD6/WqUdkvfOELtLS0cOjQIerq6pLy41IN2W4HuhjRuSVEgptWBIgV5O0IQ2pXOKJcT+smKCZ6EToUiEqNYDCoKnnhwCu2dsQgL8zatm/fTlpaGsuXL2fx4sU4nc6kfjGiDFi4Jor+EWKATV2NiS0mm82GJEm4XC51YBaDs6IoatdUl8vFmjVrqKqqYv/+/Zw4cYKLFy8ybdo0GhoamD59OmVlZUyaNIm8vDyOHz/Oiy++SHV1tVp5IRDGgRMJcY0Eg0E6Ojro6uoa9xWsuD6i0ai6QpQkibNnz3Lw4EHeeecdjEYjhYWFzJw5k7q6OoqKilRBWV5efkPh90kG61AoRHd3N5Dw0DGZTHg8Hq5cuYIsy0yZMgWj0ZjUL+Ru5IyIMlnhUi22srTCS7Syt1gsVFZW4nQ61ccIQZKatCyElDaap42sarddRX6CtnJOVLtBIs/q29/+Nr/85S955ZVXKCoqIicnJ6kD/HgRCAS4cuUKQ0NDVFdX43Q61UjaRKj6EVYEkKjkcrvdeL1ecnJyqKyspK6ujrfeeovLly9TU1OjunCHw+Hb/tnvuBgRGeminEvsyYqLVJtRHAgEkky2bkcISCg4rSKHqytH0ZhKPFaEaIPB4K1bmX8OEBekmAjFvi7cXKOsT/NeAvH619vbF//XZounhuPF8wsKCtSa/wULFrB69WrMZjMdHR2MjIxQU1OjvqYwMRMi4pN8XkiO8GgTbsW2k9PpZNq0aarh1Y4dOzhx4gRtbW2sXLmSpUuXkp6ezuzZs8nIyOC5557D7/dfc32P9yCsRYTbBWazmYsXL/LTn/4Ut9s9jp/saidukbgsfCFCoRD9/f10d3cTj8dpaWnh3LlzvP7662pvj/vvv5/h4WHKy8uZNGnSp3p/MT41NjYSiUSor69XX+vYsWMMDAywYsUKtTWAEK7aFe2dRFiHi2trdHRUNbEUzTCHhobYtWsX9913n5p0LXJrrjeGa+/V65V2a69j7e+1/9ZeTzabjQULFuDxeHjuuef4p3/6J374wx+qTs3Dw8M4nU513hHR0evdIyISc7MiT3zHaDSqLly0CeQjIyO8/fbbZGZmMn/+fDVSLMqQxxtxDNxuN0NDQ/zsZz/jT//0T9UoXGZmJh6PR3XUFi6vqbYKt4O7YgcvPA9Ea2NhzS5JUtKEr91DE5nQt6r8r3czCCGiVddw9cSIJKrx9kDQuXsYDAYsFktSCP7ChQscOXIEi+X/b+9Mg6M603v/U0vdrVYvUre2lpDQ1pLQ1hgBEqtYbBY7xgzJ2MXE8Y0ziytTcz1VuXfuh3zIh6RqqpxK5oPr1tzKZCqTVMXLhHEZY2Mcm82DASEwAgRik9CGNrQvvXer+34Q78vpRmBshCTg/KpcBqRezznved7n+T//J5GcnBx5PjwqzYPYEer1einws9vtXLhwgf7+fgKBAN3d3RQVFaHT6aKGZC1klNewWLwXLVrEunXreOutt+bxnSHbFpWOykajkUAgwPjtYZRer5dAIMCtW7eA6Zui1Wrl2rVr1NTUSFGuKOOJcuGDZC6EwePJkycZHh7m9ddfJzExkYsXL3Lz5k1sNhuZmZkkJycDRM2jmYsyjXh/Yh0Vs8QAKSQVE9i///3vy2DE4/HMyWZOZBhFgLh161ZOnDjB/v37SU5OJisrS163sVlVEVAFAgF53L7tmq8c7KrMWIlskGhtTklJwWKxRGVpF4opmxAMnzlzhomJCXw+n/x5e3s7OTk58vwT5wPM/oZnTuzghVJXZBzgjtthMBjE7/fL9Lmyne5RpCBnUsDHitACgYA08FJ58lHOTBJGZ36/n76+Pk6cOEF1dfUjnRcjzr1wOCwXfuGn4nA4sNlscocuOg8eJ5Q3TNEZUVBQwI4dO+ZdxCdKdwkJCVFeLT09PZw7d46mpiZyc3NZvHgxBQUFZGRkkJaWRm5uLjk5OWRkZERNU1WWJB5k/QoEAoyOjtLZ2YnJZCI/Px+YbgPv6emRJTjhZCpKkzB72eNvQgRVsXotMWKjo6ODW7duUVZWJsdnzJV/jCgziK6PnTt30tPTw5kzZ7BarezcuZO0tDQAhoaGMJvN6PV6kpKSZGAnPpcyEBHn6YMEe+Pj4yQlJaHVauX9TavVSnsAi8VCcXFx1Boy3+VJgVarxe12093dzcGDB8nJySEnJweYtq6/cuWK1CspS2cP+t18G+YsNAuFQlJICHciSvF35UwaIV6abe6l3lZGeCJla7FYFoQpjcqjRyzyPp8vyvI7Li5OCmTFzUB5js7GzlS56xQBidKzJC4uDpvNhs1mu+v1hHGU+AwLldjvSOh5li5dytKlS+fpXU0Tm64XIsuuri6+/vprmpqaWLRoEQ6Hg8WLF5Oeno7JZIpav5Q36NhS8DedH6FQiAsXLhAKhVixYoUUbebm5lJZWUlVVZXUKMUGA3PVTaMUIIsARIhZW1tbuXHjBnV1dRQXF8vP9KDTeh8W8R2I92S323nppZfYs2ePnDa8fft2EhISZFAyPDwsvXpENkz5vXq9XuDusu69UApSlV2Ft27d4sKFC2RmZlJWVobJZJKlrYVURg2Hw7S1tdHX18f3vvc9GYycPHmSgYEBli9fLs9BuHPOP3bBiNKAShlkKOtyItIX6T2l++XD7gJjF+mZvkClfsXr9cpUvTgpVZ5sxI1fOfVS/JswRIM7KWFx3ir1Rt8VIeYTgUfsAqg0GBIZHHFNLKQF7X4oPXxig7j5DqKU36FotzYajeTl5UkPJDFxWeg7lOZPsZPAxc1NnEvfdIySkpIYGRmRWgzxvNnZ2bz88st33ShFqyvM7e5auSsWrx2JRKRp31/8xV9gt9vx+/3y/c2FgFT5/ELcu2LFCjweD3v37uX48eM4nc6oco3oChkaGpIBivJYftsybGxGRRi0tba20traisPhkEMvxY08ISFhVu5vD4vH4wGmbfkXLVpEeXk5wWCQYDBIZ2cnSUlJ0vU59tg/dsGIfCGF4C8YDMpBYOFwOEohHuvP8LAHayazLIjOkghFvdgBiwBKWTtTeTIRgWhiYmKUq6kwJxPCNHGTUZ6Ps3EjFTdnZYYwVoiq/LvS6no+dsnfBRFIifKT+LwztUHPNcp1QCnUBO4SpQqBuwgClJ0dyhb0mdab++F0Ojly5AifffYZ+fn5rF27FiDqXIztJJmrbqnYdlylkZ/X66Wnp4ehoSFKS0vl+1Vq8uYC8d2ILg+tVivdaw8dOiQDBK/Xy8DAAKFQiPT0dBmIiPNRdAKKz/Eguo5AICADRmXwNTExwdjYGFarVXZfQXTwtBBKNcJX6dy5c5SWlmK329FqtdTX19Pb20tVVRUpKSlRhooiozTbzIlmBO5cpH6/X2YfROoqLi5OtjkpD9BslWpiFwaRahTK6sbGRpKTk6mqqoqKjoVoR+XJ5V5pdXEDFSUc5ZRU8XuzJUATu22R+RCZhNhBciJTA3d24Qsdpd4gts1zIbx/kbUVmyGhPwDkZkS4gSrfu3AGFb8/U1D1IMGI2+2mrKyM73//+/z617/m/fffJzU1lYKCAgAZIMU+/1wFceK1YwW5Xq+XtrY2Ojo6qKqqkmJq5TiCuWoAULrRimNnMBhYvXo1FRUVcmDfmTNnePvttzly5AhLlizhhz/8IRaLhZKSEkpKSu7a+D6I7kX5GUU31tDQEBcuXKC1tZWqqiqKi4tlMNLd3U1PTw/5+flRpY/5IhwO09jYSFtbG6+88goGg4G4uDg+++wzXC4XmzdvlrOwtFqtDNAehV7pkQcjoVCIQCAgF3QAk8mExWLhhRdeIDExkcTExKjR3SIjMhsn80xW7qIuHwqFOHDgAHv37iUnJ4c33niDwsJCvF4vk5OTamvvU4DSAdPr9UZlKLRaLQaD4a5shbKF72ERXWPKlmiBWFiFv4nStwEejzLNTMEIPHg9/lGj1+ulVkiMNRAl5fu1bovjMdMNS1gYPEiLqNFoxOPxsHXrVrq6unjnnXfYt28fL7/8slyLlF0a4mYwV7tqZSCk1AqMjo7S2tpKZ2cnr776KhaLRXamCN+WuWo9Vpp2KbNHZrMZs9lMOByioaGBX//6/6LTJfDRRx8SCAQ4cuRLPvzwI17/q78ie1EuSUYjU+Fpv5lE3YPff0Tnlcvl4tatW9TX13P48GHa2tr4h3/4B1kWGh0d5Y9//COnTp1i06ZNvPjii/Pesdnb20tLSwsmk4nq6mpZJThx4gSFhYWsWLFCdonBne9bmY2aLeYkMyLq3Mr2OZ/PR3l5uUyBK62WlRf5g150selEUWpRtnO53W45YOnQoUO89957DA4OUldXR3V1tRTuiKyJcpLnTLu4hTJfQ+W7o9QyKNP0Im0rNEzKOqmy8+Jhud9iJJ5fvL7y3yORiOxCm+l9LISsA9wJOsR3vBBRZmBnCgrvx0zr07d5vDL9vXv3bm7dusXJkycxmUz82Z/9GXa7PSojoTzvvm176EzlE/F8ymyV8j9RWhPCfpi++Xo8Hs6dO8fU1JQsK4lRDGKdnQsS4hPg9sfRxGnkn+PiIkCE8NQUkcgU165e5uqVZt577z0qKiuBaX8hTbwevcFCkimZMBBGg04/fT5MuMYxm8xMhaeYCobQ6+8Ep63Xb9DW1kZ9w0na2tq4ceMGCQkJVFRUkJeXx5IlSwiHw7zzzjsUFRWxbNky9Ho9lZWV1NfX8+6772Iymdi6dWtU506sJu1hAzrl+aIsI4kSdF9fH263m+eff17eK48dO0ZeXh6rV6+Wvy/+L66VRzFXZ06CkUgkwsTEBO3t7dLmOjExMSqSFb36IhJ/0IPg8XiiyjtKEyPxxYmed6PRyOHDh/m3f/s3hoeHcTqdPP/88zidTkpKStDpdAwODtLS0oJGo7lrPLyKiorKbCPEgWIGiN/vp7m5mczMTLZs2SIdTUVZGb7bjWqmoHWmQYACEfCKdVS5G56YmACguro6aj4VLJysF4AmPo7hoTEGB2/d1ke0k52dhdVmo6SkhP/1i//DxKQXQ5KWUBgiYfD7PSQZkjCazPj8vukBgJevcO7cOVpa2nG5XBgNJiwWE8nWFHJycli8eDEZGRmUlZWRl5eH1+ult7eX3/3ud/zLv/wLr776KnV1dVIT1NTUJAOSNWvWAHfM2eBucfR35V5GiMKBuqmpicnJSZxOJ2azmaGhIT766CMsFgurV69+6Nf/Njzys0YM3lm+fDm3bt2S1rLV1dU4nU6ZMRGmU0oexDhH/NztdqPRaOQoeIg2dDl9+jT79u3j4sWLZGdn8+KLL1JVVYXD4ZBR3pkzZ/jggw/o7e0lKyuL11577RF8IyoqKirTiGDA7/djMBgoKytj69at7Nu3jyNHjmA0Glm/fv2stsrOZM2u/JnyP6Wzss/nkzb1Fy5cYHBwUJq0KacPi8fMtkPnd8HtcpGalsbGjRvZs2cPf/u3f8uLL77IG2+8QX6Bg5QUPZZkI6EpmJoKkxCv4cSJE1y5coXWG9dJ1OqmPUTiExgfHycuLo7U1FQK84vIy8tl6bJnsFhM0r9EecMvKCigp6eHPXv28Omnn1JSUiIngNtsNn7729+yf/9+rFardF2OzebPBsqMiNIxtq+vj66uLvR6PSUlJQD09/dTX1/Prl27qLydQZor5iQYMRgMbN68GZPJxH//93/zySefcPnyZTZu3MjatWujnOmE8ZNWq/1Wmo3YtKC4OM6dO0d9fT3Hjx8nGAyydu1aNm3axJIlS+TE1fr6es6ePcuRI0dISkqisrKSjRs34nA4ZvW7UFnYLJTSxoPyuL1flZmJ3XTV1NQQiUR45513+OKLLzAajdTV1UkjraSkJCkifFjtyDc9XllyEoFFb28v58+fJxQKUVVVBTCjRmSujM/uh/F2EFdRUcHf/M3f8I//+Bb//M+/4ty5c+x4aRd1m7ZT5HCg1UIwGGZgeIimpiauXr3KyOgQ2Zl20tLSKCtdQkFBATZbBgaDgUSdAZ0ugbh4DVrtzGU5s9nMzp078fl8fP3117z77ru88sorchDnyy+/zIEDB3j//ff58Y9/zOLFi2XnlMlkeiQutmLkisvlorGxEUA2boRCIa5evUpaWhrl5eVz3un2yIMRnU7H1NQUJpOJzZs3U1hYyMmTJ7lw4QIfffQRLS0tVFVVUVNTQ2pqqlQkP2gaUlj5KtsuA4EA165do62tja+++oqBgQHS09PZtm0bmzZtwmAwMDExQV9fH2fPnuXjjz9mdHQUo9HIq6++yurVq0lOTpbCQRUVFZVHxUxeGdXV1QwODvLFF19w8OBBKTBUtlWKdW82UA5vVKJsWRXrcUdHBx6Ph6VLl2I0GqMmFysfv1DWTr/PR6LBwO4f/IC0tFQ+/PBDDh8+zM9+9iav/o8fsfsHr7F9+wYMiQn4EhMpKipi6dKl5ORmY7Ukk5CQQKJOfzsIvJ3pub0PCARD0qJCHA8x6gQgLS2NF198EZfLxaVLl8jKyuKFF14gOTmZLVu20NnZyddff83evXv567/+6yg/j9n4/pRdL0oTz4mJCZqbmwmFQqxfv574+HhGR0c5fvw41dXV0sBuLpmTbhplUOFwOMjNzaW0tJTGxkbOnDlDd3c3V69eZcWKFVE1yAebjeQmAAAYtklEQVQRQinTgGLy5aVLlzh9+jQtLS3k5uby2muvsXLlSukhMjY2RnNzM6dOnaKhoYGsrCx27dpFYWFhVDbkUfVTqyxMHjcx8uP2flXuRnQOik4ZUTL2+/289NJLeL1ejh49yhdffIHdbic7O1s+9tsGIjMJWIWAVnT+zPScIliKRCL09PRw7do1zGYzq1atAu7tQrsQBMuuyUlMt4cMetxu6urqePbZZ9m/fz+//n+/4cCBA4yMTrI4L4fysiJsVgubNm1Cp9NhSNQjvg1xpYVCt00K4+LRxINOd+9bqCiJZGdns2HDBjweDw0NDRgMBjZt2oTNZmPr1q0Eg0HOnDmDzWbjtddeQ6PRRHVRPQxKY0YxYgJgcHCQsbEx9Ho9paWlTE1N0dXVxfXr19m9ezdZWVkP/drflkcejExMTGCz2YDpdKQYrrRixQqcTieVlZWcP3+eCxcucPnyZS5dusS6desoLi5+IEW2CFiCwSBnz57l0KFDdHR0kJaWRl1dHRs2bGDRokWYzWZ8Pp8s27S1teHxeNiyZQulpaU888wzshdcuAjea+qkioqKymwgbhThcDiqRVWI+Dds2MDExASXLl1i//79bN++ndzc3CiNxoMS2ymj9LERfjrC7FG40VosFunTEQqF6OzspKuri6ysLAoLC2XHjXAwnqnrZz4xmc1MjI/T3t6O2+3G6axCp9ezY8cOnn9hBz/9n/+bUw1naW5uJiMjjVRbMskW4S8VxuV2Tbf3a0RLuoZIBEKBMKHQFGjiiESmpL5GeUyULfhVVVW43W4OHjzImTNnSElJoba2Vk4En5yc5Pjx42RnZ7Nu3bpZC+SUniDivfX19dHW1oZGo2Hp0qXExcUxNjZGY2MjGRkZ5Ofny3vhXPLIgxERiAQCARmIiL/rdDrWrVtHQUEBeXl5nD59mtOnT9PZ2cmaNWui2m3vhV6v5/Tp0xw+fJjm5ma0Wq0c771kyRLMZjNjY2OcP3+eS5cuSfVwWVkZNTU1FBcXk5qaKtt5lSZtooVTRUVF5VEQuwsWOoHk5GS8Xi92u53nnnuO9vZ2vvjiC7KysuSu9dsMK1NmRYRoNRKJMDo6it/vZ3JykuHhYfr7++nt7WVwcBCXy8XOnTupra2VHixjY2P4fD7sdrvsNlQ6liqFkgupq+bmzZtcvXoVuz1TZkq8Xi9r1qyh8dxFrFYraanJhMNAHPgDfhK0GkxGExEicnBqQkIiGg1odRpAcztlcrdWRmkOZzAYMBqNVFdXMzY2xueff86hQ4ew2+2UlZVRVlZGXV0dv//97/nggw/Izs6mrKxsVlqkhbWGUkx88+ZNurq6SEhIYOPGjfh8Prq7u2lqasLpdLJ48WIAxsbGZCA6F8zZ2RKrqhYXn9frlZMCHQ4Hf/zjH7l69SpHjx7lwoULbN68mfz8fDnxUJgSCROl5uZmDhw4wLVr18jPz6e2tpbVq1eTmZlJOBxmaGiII0eOcPz4cXw+H4sXL6a2tpalS5dGlWSUGRClE99CiO5VHh3i+ArPDuGsKWYTCe8E4QEgUtqztdgqTc/gjjW1cl5OMBiMcgEVPIrJmSpzjzIdrxQsGgwGIpEIixYtYteuXXz88cfs378frVbL9u3bgeiRGS6XSwofxRRa0QHj9/sZGhpieHiYkZERuru76e7ulo/T6XSkpaURiUQYGBjA7/djMpkwmUz4/X60Wi3d3d2cOHGCzMxMli5deld5RrmbXyiByOjICFabjbGxMfbs2cPw8BA///nPMZvN9PcP8l//9V+sWbMG8+0AJV4DwVAQvU4P3Lb4J+5bdQUpsyNKDY3VamX16tWMj49z6dIlfv/73/P6669TUFDAli1b6Ojo4MMPP+TQoUO43W5WrFghM/RKryyDwSCDDLFhnqkjCu5s+pVjJNrb27ly5QolJSWkpqYSDAa5ceMGHR0dbN++nfz8fKampuY0EIE5DEbuhbjgQqEQRUVFZGZm0tbWxtmzZ7l+/Tp79uyhsrKSlStXUlBQgMlkkid9fHy83D3Y7Xbq6upk2qurq4urV69y4sQJhoaGiI+PZ+XKlaxatYrCwkLVXVUFuNP2FgqF7jLOEwGIuJCF8+psmBEJlGnyWAGhSHUrg2Ox6xI/UzN3TzYiQ7tkyRK8Xi+ffvopX331Fenp6SxfvjxKtB8MBpmYmCAQCOByuWhqapIaucnJSTQaDVqtlkAgwPDwMKOjowwPD5OUlERWVhbJycnk5uZis9lISUmRgYjwhLpx4wZ+v5+CggJycnIWTMBxP6w2G6FgkLy8PH784x8zOjrCT3/6U5qamrClZrDx2RfYuu1PqK15BoBJlxeD4bZGhgh31CLfDZHZECV/u91ObW0tHo+Hy5cvc+zYMYxGIxaLhd27dxMXF8e//uu/kpWVRWZmJrm5uTKg1Ol0GI3GqPbf2OGNsShNO4PBIKOjo7jdbux2O8XFxRgMBnp7e+nv7ycnJ0cGIPOxyVkQZ5NYYIULptVqJTk5GYfDwYkTJ2hububKlStUVFSwbt06SktLgekDvGTJEhYtWoRGo5HirsbGRhoaGhgZGaGnpweHw8HKlStxOp2kp6fP50dVWWCIi1h0C+j1epl9EHVWcWGKwGGmEQPfFeWu5l7zbsQId2XGRAwFU3nyETeilStXMjIywieffMK+fftIT0/Hbrej0+lISEggKSmJhoYGbt68SSAQoKmpCbfbzfj4OPHx8eTn55OXl0daWhq5ubkYjUZyc3MxGAxyQJxOp4vyaRJl9o6ODpqbm/F6vWRnZz9WhpDx8fGsX7+e9XV1uCYncDqd9Pb2signD2vaIpZVLwXA55+2lEiIn74GPV4PZsPDO8mKDY0IGioqKnC5XAwODnLkyBHi4uL48z//c2w2Gzt37qS1tZW9e/cSCATYtWuXzIQoP49y9s/91iIhPRAZlImJCbRaLUVFReTl5REOh7l48SLXrl1j+fLlUV00s7npehDmPRgRC6xIkYsvTwwvKiwspL6+nlOnTnHq1Cn6+/txOp1UVFSQk5ODzWaTF8aNGzc4d+4cDQ0NjI2NkZOTw+7duyktLSU3N1e+ZjAYlK+5ECYnqswfsbNSxMA6n88ndx5er1f+TPmY2bhYRQlmpvNQWXsWZRrlwhMMBu9K0QrU8s2TgdANiJEazz//PB0dHdIT6Sc/+YnUvMXFxTE4OEh7eztWq5Vly5aRl5eHRqPBaDSSnJwsp5ObTKYZ9Qh+vx+3243H4yEQCHD+/Hn8fj/d3d0MDg6SlZUl11KlmdZCJXhbqxgfHw+RCAaDgedfeOH2T+OZQkMECN2uYiTqbxu2BQMYZyEQgeiZOSJD4nQ6CYVCfPDBB3z22WeUlJSwatUq7HY7v/jFL3jzzTc5ceIEOTk5rFmzRg6ZVZZrY4fVKYXJ4u9arTZqPpTJZJLDA/Py8nC73bS2tnLr1i0qKyujBh7OddZ13oMRofYVAUKsurugoIC0tDSqqqo4c+YMDQ0NXL58meXLl7Nu3TrS09PR6XRcunSJY8eOMTQ0hNVqZePGjaxcuZKioiJ5wHw+X1TaeyGY8qjML8obvvCsEVkIq9WK3W6XttixUz1no9NKqXIXehVldwJE16BF/V4ZCN0rIFF5/FHO7IqLm9YubNu2jZ6eHg4cOEB5eTnbtm3D7/ej0+morKzE4XBgsVjIz89nZGSE5OTkKJGpWG9HRkbw+/2MjIzI4KOnp4fm5mZ6e3tlicdkMpGRkUFeXh5Op1Nq7R6H9VOr08Ht8qcmPp54zZ0g3efzkaBPgjiIi4NE/fT17HK7pkeKaM2z8h6U35M4TmKqcCgU4t133+U3v/kNJSUlpKSkoNPpePPNN3nvvffYu3cvWq2W5cuXRw0tjDW8U5Z4YzfZHo9Hdmfp9Xp5fsB0t+vk5CRms1kKo0WQ+cSZnn0TQtkduztUqr4tFgtOp5Ps7Gzy8vJobGyks7OTlpYWcnJycLvddHd3EwwGqa6u5rnnnsPpdBIfHy8FgnB337u6e1QRKFsTExISMBqNFBcXs2vXLoqLi2WQrHQIng1ixW7KuUzivD1//jytra0YjUaKioooLCxEp9Pd1wdHPbefDBISEqQwNT4+HrfbTVVVFW+88QZvvfUW//7v/45er2fLli1oNBpZwhaBtcgaj4yM0NfXx9jYGKOjo7S0tHD9+nXC4TAejweLxUJeXh6JiYlotVpyc3OlfkCv15ORkUFxcTFFRUVScDvfVu8Pgsftlv4tmtvZEW5fG4mJifiCkKAFjQbCEYiPA5PRxFR46hue+cER2q64uDiSkpJkeVWj0eB0OolEIvzyl7/k7/7u7/jlL39JSkoKGzZsoL+/nz/84Q+cPn2alJQUysrKgDvHVil8VgYqsShHCVitVvkct27d4sCBA/T29lJRUYHdbpfvC5hza4t5D0ZEO5hYPIVYMD4+Xhq0hEIhpqamSEtL47nnnqO6uppjx45x6tQp2tvb0Wg0lJeXs3btWp555hmpjBb1MYH4YoWz6uMgwFJ5tIjzTqjTledfbm4uOTk5UYuuRqMhEAjI9OfDXqxKpbwySyK6H9rb2zl8+DA9PT0sW7aM4uLiqF2uypPPTBmIsrIyfvKTn/CrX/2Kjz/+WAYPw8PDRCIR+vv7uXXrFpcvX8bn80nxtdh5u1wumbq32WxS0Lh48WKsVqsUsQqEaHI2J8rOBUnKUtTtbLv29vU8nQHQMxWeDkQAxOUcr4lnwjVGiunh/TZEW7RyUywyrUlJSaxdu5YdO3bw9ttv43Q6+dGPfgTAtm3bcLvdpKSkRK0zyuz+TH4uogNHeNeI7j+/3y+DTzG09ssvvyQlJYV169ZFZeEAmaWdK+b9bFKWZSD6ixAHUCiHxUVps9n43ve+x7Zt22hpacHtdlNYWEhmZiYwbSCTmJgoU1HhcDhKgRybbld5ehGapWAwiNvtxuVySb2IMpBV9vwru7keFuVCIhb6yclJmpubuXjxIvX19bjdbiorK9mwYYNMkU9MTODxeFTNyFOAxWIhGAwSDAal/fro6Cjr1q1jfHycv//7v+edd94hIyNDbsA8Hg/d3d2MjY0xNTWF1WolKysLh8NBVlYW2dnZZGRkyCmxcCfoEeehsrtMq9VGnWePT1lQQzDgIxAIYTDo0er0EJn2DdHpDUSAQAjEfsPj9REOh7AYTTMEIt9eXyiCjvj4+KhSr/j+9Ho9Ho+Hl156if7+fn71q19hMBj40z/9U1JSUvjhD38oyyyBQEDOrYHpMlNsOSUSieDz+fB6vQQCAS5dukRcXBx9fX309vYC09m28fFxWYJzOBxUV1fL54TprNFc3yfnPRgRxC6eM00ujBX5GQwGnE7nXc8lMiPKx8VOBFZRgTvZiPT0dMrLyzl27BgajYZnn31W6pHEDkHsQoSafWpqCp1ON+PORNkhA3fKO8KxUpndUC4mXV1dHDx4kMOHD3P9+nW2bt3KD37wA6qqqvD5fFJQW19fT0NDA7m5uSQlJclrQ9R71WDkyUKr1UYFwWlpaQBs3ryZSCTC/v37uXTpEgUFBdTW1uJwODCbzeTn58vS4zcFz7Hrq/LvypZ38X4WBPc8ze+8d60u8bZJWVg+Rqc3ABrigERFtclkSFQ87X2Cjwe8vJQ3dOWflfcjrVZLfn4+P//5z2lvb+f999/H6XRSWlqKwWAgKSlJbsyVm3fhnDo+Ps7Q0BBjY2NSfOx2u/H5fFy9epXBwUH6+vrw+XykpqZSWlpKeXk51dXV1NTUYDQa5bEVE5jnw0E3LvL4hLgqKo+MUChEY2Mj//Ef/8HJkyepqanhL//yL8nJySEvLw+402kg2h3h7nkf39QVA8iUqWil9Pv99Pf3c/nyZT799FOampqorq7mlVdeobi4GIvFIhey9vZ2PvnkEw4cOEBHRwf/9E//xNq1a+V7mmlcuMqTjcj8xsfH3xUk+Hy+qHZwJQvFsv1pRpSFxcbm9OnTvP3221gsFn72s59RXFwsmzm8Xi8ulwuXy4XX6yUYDHL69Glu3rzJ5cuX6ezsJBwOk5OTQ0VFBYsXL6ayshKLxUJmZibp6elyUr3oXBWdPkrTRWUb8lyeH2owovLUo2yZ6+vr4+DBgxw9epTOzk7q6upYvnw5dXV1MqUtZhfp9foHvlhFh46YByIe53a7ZavmyZMnMZlMbN26ldraWpKTk+Vr9vT08Pnnn7Nv3z58Ph9btmxhy5YtlJWVyd2S1+uNWljUYOTJR5QURbZOTJAVmRRhlRB7YxG7X9XaYGEgpAVarZa9e/fy29/+ltLSUjZs2MDk5CQ9PT20trbS1dWFx+MhMTERk8nEqlWrMJvNWK1W2a6dnJxMeno6VqsVn8+HXq8nMTExyiwxISFhxrVLrFFK/dpcoQYjKk81yt2hcn5DU1MTBw8epLGxkcTERCoqKmSXFhBVcoG7y4zKbjChd/J6vVJ3IiyY//CHP9Df308gEGDJkiVs2rSJZ555Ru5eJiYm+PTTT/nyyy+ZmJjA4XDw0ksvUVNTE9XV4/P5CIfD0ln4m5wZVZ58lK2eMwUiyvNXZf4QYmDl0Nf//M//pL6+HoPBQHJyMqmpqZjNZvR6PQaDAYvFgslkwmAwkJqait1uj8qKxbpJK4ktISuZz3VDDUZUnmpigxEhChNtcx999BGdnZ1cvnwZv99PTU0NO3bskMZPoVAo6uKNLdfM1HXQ3d3N559/zvHjx6X4ura2llWrVsle/5s3b3Lz5k1+97vfMTk5yZIlS9iwYQN5eXnYbDaSk5Nl5mOmhcPn86k6qacAsZONde+dmpoiEAjMOIZeqWlSg9X5Z2BgQJqNiet2cHCQgYEBvF4vJpMJq9WK2WyWWVVx/JTHXGTGhNmZVquV3lqx3aPCa0asHwvhPFCDEZWnntguAphezMVOpb+/n8bGRk6ePElHRwdpaWmsX7+empoaFi9efJdXiHIcPCAnfrpcLk6dOsXBgwcZGhoiNTWV9evXs3btWtnjPzAwQG9vLw0NDXz11VdS7V5bW0tpaalszRTM5IIpFqTHwQdCZfYIBoOya/BBOiFUzcj8o8xSKNeh2Os6EAhIKwHlv4sWbaE/uxfi8bHdN6KMtxAyZ2owovJUo1yQ/X4/QNTwMZ1OJ0sufX19fP755xw9epSEhAQqKyupq6uTM0LELlS0C4sgZXh4mJaWFs6fP8/58+fx+XzU1NSwefNmcnJy5K52YGCAo0ePcuzYMSKRCA6Hg1WrVlFdXU1ycvJdQYayDU853Te2TV7lycXlckV1U0G0V5PK44Hf78fv90s7Cpg+tmJmUGywIFp3Z5qsq1zT7hVs+P1+gsHgXZ2nAlFiVoMRFZU5QrToikGNEF03jc2aeL1erl+/zuHDh2loaCArK4vy8nJqa2spLi4mKSlJBi9iEWhra+PgwYOcO3cOu93Otm3bqKqqksZ+fX19ctTB8PAweXl5rFy5kuLiYrKysqTRmtCbhEIhvF4vZrP5npqXYDB4z8F7Kk8eMx1vZRfX/XQCKvNLIBAgFApJvdfExERUUALRGjTljCrlxud+5bdIJBLl3aXMriyUsp0ajKiofAOxpRcxOKyvr48vv/yS/v5+NBoNy5YtY/369RQUFMjuhoSEBEZGRrh27Rrj4+M4HA5pXNbV1UVLS4uct5Sens769etZtmwZGRkZqkGfiorKU4MajKiofAMiGFHuSIS3Q2dnJxcvXuTixYu4XC5sNhslJSVUV1dTVFQkf0+0Aotyz7Vr1+jq6uLw4cOkpaVRWlrK0qVLcTgcWK1W1bhMRUXlqUINRlRUHpCZghKA8fFx2traOHv2LOfPn8fr9VJeXs6yZctYt25d1GMGBgZobGzk+PHjXL9+neLiYqqrq1mzZo3s0FFRUVF52lCDERWV+xBrHCZGsAtXS+Wgu9HRUc6ePcuZM2fo6ekhHA5TXl7OihUrsNvtNDc3c/LkSSYmJsjIyCA9PZ0dO3ZI23mYrv0rn1sVIaqoqDwNqMGIisp9EMLA2GyIEuHIKnw9uru7pQ6kvb2dgoICzGYzAwMDuN1uHA4H69evp7y8PKodT+kEC6pXiIqKytODGoyoqHwDQokOzGijLFTqSrHpxMQEo6OjtLa2cuXKFQYHB2WXTGFhYZQTqwh0Yu25H5cx7SoqKioPixqMqKg8AGKoFCADB3HpxJqQhcNhGZh4vV5GRkYIhULYbDbMZvOMxmgC4Rcy02AzFRUVlScVNRhRUbkPYhrqTIGB8tK5lweAmIopfkc5T0b4gsSaramoqKg8bajBiIqKioqKisq8Mv/TcVRUVFRUVFSeatRgREVFRUVFRWVeUYMRFRUVFRUVlXlFDUZUVFRUVFRU5hU1GFFRUVFRUVGZV9RgREVFRUVFRWVeUYMRFRUVFRUVlXlFDUZUVFRUVFRU5hU1GFFRUVFRUVGZV/4/0eWhNZYoW0AAAAAASUVORK5CYII=)
05 後處理的問題 在有機合成中,後處理的問題往往被大多數人所忽略,認為隻要找對了合成方法,合成任務就可以事半功倍了,這話不錯,正確地合成方法固然重要,但是有機合成的任務是拿到相當純的產品,任何反應沒有100%產率的,總要伴隨或多或少的副反應,產生或多或少的雜質,反應完成後,麵臨的巨大問題就是從反應混合體係中分離出純的產品。後處理的目的就是采用盡可能的辦法來完成這一任務。 為什麽對後處理的問題容易忽視呢?我們平時所看到的各種文獻尤其是學術性的研究論文對這一問題往往重視不夠或者很輕視,他們重視的往往是新的合成方法,合成試劑等。專利中對這一問題也是輕描淡寫,因為這涉及到商業利潤問題。有機教科書中對這一問體更是沒有談論到。隻有參加過工業有機合成項目的人才能認識到這一問題的重要性,有時反應做的在好,後處理產生問題得不到純的產品,企業損失往往巨大。這時才認識到有機合成不光是合成方法的問題,還涉及到許多方麵的問題,那一方麵的問題考慮不周,都有可能前功盡棄。 後處理問題從哪裏可以學到?除了向有經驗的科研人員多多請教外,自己也應處處留心,雖說各種文獻中涉及較少,但是還有不少論文是涉及到的,這就要求自己多思考,多整理,舉一反三。另外,在科研工作中,應注意吸取經驗,多多磨練。 完成後處理問題的基本知識還是有機化合物的物理和化學性質,後處理就是這些性質的具體應用。當然,首先要把反應做的很好,盡量減少副反應的發生,這樣可以減輕後處理的壓力。因此,後處理還是考驗一個人的基本功問題,隻有化學學好了才有可能出色的完成後處理任務。 後處理根據反應的目的有不同的解決辦法,如果在實驗室中,隻是為了發表論文,得到純化合物的目的就是為了作各種光譜,那麽問題就簡單了,得到純化合物的方法不外就是走柱子,TLC,製備色譜等方法,不用考慮太多的問題,而且得到的化合物還比較純;如果是為了工業生產的目的,則問題就複雜了,盡量用簡便、成本低的方法,實驗室中的那一套就不行了,如果您還是采用實驗室中的方法則企業就虧損了。下麵隻簡單的介紹一些工業中的方法。 後處理過程的優劣檢驗標準是:(1)產品是否最大限度的回收了,並保證質量;(2)原料、中間體、溶劑及有價值的副產物是否最大限度的得到了回收利用;(3)後處理步驟,無論是工藝還是設備,是否足夠簡化;(4)三廢量是否達到最小。 後處理的幾個常用而實用的方法: (1)、有機酸堿性化合物的分離提純 具有酸堿性基團的有機化合物,可以得失質子形成離子化合物,而離子化合物與原來的母體化合物具有不同的物理化學性質。堿性化合物用有機酸或無機酸處理得到胺鹽,酸性化合物用有機堿或無機堿處理得到鈉鹽或有機鹽。根據有機化合物酸堿性的強弱,有機、無計酸堿一般為甲酸、乙酸、鹽酸、硫酸、磷酸。堿為三乙胺、氫氧化鈉、氫氧化鉀、碳酸鈉、碳酸氫鈉等。在一般情況下,離子化合物在水中具有相當大的溶解性,而在有機溶劑中溶解度很小,同時活性碳隻能夠吸附非離子型的雜質和色素。利用以上的這些性質可對酸堿性有機化合物進行提純。以上性質對所有酸堿性化合物並不通用,一般情況下,分子中酸堿性基團分子量所占整個分子的分子量比例越大,則離子化合物的水溶性就越大,分子中含有的水溶性基團例如羥基越多,則水溶性越大,因此,以上性質適用於小分子的酸堿化合物。對於大分子的化合物,則水溶性就明顯降低。 酸堿性基團包括氨基。酸性基團包括:酰氨基、羧基、酚羥基、磺酰氨基、硫酚基、1,3-二羰基化合物等等。值得注意的是,氨基化合物一般為堿性基團,但是在連有強吸電子基團時就變為酸性化合物,例如酰氨基和磺酰氨基化合物,這類化合物在氫氧化鈉、氫氧化鉀等堿作用下就容易失去質子而形成鈉鹽。 中合吸附法:將酸堿性化合物轉變為離子化合物,使其溶於水,用活性碳吸附雜質後過濾,則除去了不含酸堿性基團的雜質和機械雜質,再加酸堿中合回母體分子狀態,這是回收和提純酸堿性產品的方法。由於活性碳不吸附離子,故有活性碳吸附造成的產品損失忽劣不計。 中和萃取法:是工業過程和實驗室中常見的方法,它利用酸堿性有機化合物生成離子時溶於水而母體分子狀態溶於有機溶劑的特點,通過加入酸堿使母體化合物生成離子溶於水實現相的轉移而用非水溶性的有機溶劑萃取非酸堿性雜質,使其溶於有機溶劑從而實現雜質與產物分離的方法。 成鹽法:對於非水溶性的大分子有機離子化合物,可使有機酸堿性化合物在有機溶劑中成鹽析出結晶來,而非成鹽的雜質依然留在有機溶劑中,從而實現有機酸堿性化合物與非酸堿性雜質分離,酸堿性有機雜質的分離可通過將析出的結晶再重結晶,從而將酸堿性有機雜質分離。對於大分子的有機酸堿化合物的鹽此時還可以采用水洗滌除去小分子的酸堿化合物已經成鹽且具有水溶性的雜質。對於水溶性的有機離子化合物,可在水中成鹽後,將水用共沸蒸餾或直接蒸餾除去,殘餘物用有機溶劑充分洗滌幾次,從而將雜質與產品分離。 以上三種方法並不是孤立的,可根據化合物的性質和產品質量標準的要求,采用相結合的方法,盡量得到相當純度的產品。 (2)幾種特殊的有機萃取溶劑化 正丁醇:大多數的小分子醇是水溶性的,例如甲醇、乙醇、異丙醇、正丙醇等。大多數的高分子量醇是非水溶性的,而是親脂性的能夠溶於有機溶劑。但是中間的醇類溶劑例如正丁醇是一個很好的有機萃取溶劑。正丁醇本身不溶於水,同時又具有小分子醇和大分子醇的共同特點。它能夠溶解一些能夠用小分子醇溶解的極性化合物,而同時又不溶於水。利用這個性質可以采用正丁醇從水溶液中萃取極性的反應產物。 丁酮:性質介於小分子酮和大分子酮之間。不像丙酮能夠溶於水,丁酮不溶於水,可用來從水中萃取產物。 乙酸丁酯:性質介於小分子和大分子酯之間,在水中的溶解度極小,不像乙酸乙酯在水中有一定的溶解度,可從水中萃取有機化合物,尤其是氨基酸的化合物,因此在抗生素工業中常用來萃取頭孢、青黴素等大分子含氨基酸的化合物。 異丙醚與特丁基叔丁基醚:性質介於小分子和大分子醚之間,兩者的極性相對較小,類似於正己烷和石油醚,二者在水中的溶解度較小。可用於極性非常小的分子的結晶溶劑和萃取溶劑。也可用於極性較大的化合物的結晶和萃取溶劑。 (3)做完反應後,應該首先采用萃取的方法,首先除去一部分雜質,這是利用雜質與產物在不同溶劑中的溶解度不同的性質。 (4)稀酸的水溶液洗去一部分堿性雜質。例如,反應物為堿性,而產物為中性,可用稀酸洗去堿性反應物。例如胺基化合物的酰化反應。 (5)稀堿的水溶液洗去一部分酸性雜質。反應物為酸性,而產物為中性,可用稀堿洗去酸性反應物。例如羧基化合物的酯化反應。 (6)用水洗去一部分水溶性雜質。例如,低級醇的酯化反應,可用水洗去水溶性的反應物醇。 (7)如果產物要從水中結晶出來,且在水溶液中的溶解度又較大,可嚐試加入氯化鈉、氯化銨等無機鹽,降低產物在水溶液中的溶解度-鹽析的方法。 (8)有時可用兩種不互溶的有機溶劑作為萃取劑,例如反應在氯仿中進行,可用石油醚或正己烷作為萃取劑來除去一部分極性小的雜質,反過來可用氯仿萃取來除去極性大的雜質。 (9)兩種互溶的溶劑有時加入另外一種物質可變的互不相容,例如,在水作溶劑的情況下,反應完畢後,可往體係中加入無機鹽氯化鈉,氯化鉀使水飽和,此時加入丙酮,乙醇,乙腈等溶劑可將產物從水中提取出來。 (10)結晶與重結晶的方法 基本原理是利用相似相容原理。即極性強的化合物用極性溶劑重結晶,極性弱的化合物用非極性溶劑重結晶。對於較難結晶的化合物,例如油狀物、膠狀物等有時采用混合溶劑的方法,但是混合溶劑的搭配很有學問,有時隻能根據經驗。一般采用極性溶劑與非極性溶劑搭配,搭配的原則一般根據產物與雜質的極性大小來選擇極性溶劑與非極性溶劑的比例。若產物極性較大,雜質極性較小則溶劑中極性溶劑的比例大於非極性溶劑的比例;若產物極性較小,雜質極性較大,則溶劑中非極性溶劑的比例大於極性溶劑的比例。較常用的搭配有:醇-石油醚,丙酮-石油醚,醇-正己烷,丙酮-正己烷等。但是如果產物很不純或者雜質與產物的性質及其相近,得到純化合物的代價就是多次的重結晶,有時經多次也提不純。這時一般較難除去的雜質肯定與產物的性質與極性及其相近。除去雜質隻能從反應上去考慮了。 (11)水蒸氣蒸餾、減壓蒸餾與精餾的方法 這是提純低熔點化合物的常用方法。一般情況下,減壓蒸餾的回收率相應較低,這是因為隨著產品的不斷蒸出,產品的濃度逐漸降低,要保證產品的飽和蒸汽壓等於外壓,必須不斷提高溫度,以增加產品的飽和蒸汽壓,顯然,溫度不可能無限提高,即產品的飽和蒸汽壓不可能為零,也即產品不可能蒸淨,必有一定量的產品留在蒸餾設備內被設備內的難揮發組分溶解,大量的斧殘既是證明。 水蒸氣蒸餾對可揮發的低熔點有機化合物來說,有接近定量的回收率。這是因為在水蒸氣蒸餾時,斧內所有組分加上水的飽和蒸汽壓之和等於外壓,由於大量水的存在,其在100℃時飽和蒸汽壓已經達到外壓,故在100℃以下時,產品可隨水蒸氣全部蒸出,回收率接近完全。對於有焦油的物係來說,水蒸氣蒸餾尤其適用。因為焦油對產品回收有兩個負麵影響:一是受平衡關係影響,焦油能夠溶解一部分產品使其不能蒸出來;二是由於焦油的高沸點使蒸餾時斧溫過高從而使產品繼續分解。,水蒸氣蒸餾能夠接近定量的從焦油中回收產品,又在蒸餾過程中避免了產品過熱聚合,收率較減壓蒸餾提高3-4%左右。雖然水蒸氣蒸餾能提高易揮發組分的回收率,但是,水蒸氣蒸餾難於解決產物提純問題,因為揮發性的雜質隨同產品一同被蒸出來,此時配以精餾的方法,則不但保障了產品的回收率,也保證了產品質量。應該注意,水蒸氣蒸餾隻是共沸蒸餾的一個特例,當采用其它溶劑時也可。 共沸蒸餾不僅適用於產品分離過程,也適用於反應物係的脫水、溶劑的脫水、產品的脫水等。它比分子篩、無機鹽脫水工藝具有設備簡單、操作容易、不消耗其它原材料等優點。例如:在生產氨噻肟酸時,由於分子中存在幾個極性的基團氨基、羧基等,它們能夠和水、醇等分子形成氫鍵,使氨噻肟酸中存在大量的遊離及氫鍵的水,如采用一般的真空幹燥等幹燥方法,不僅費時,也容易造成產物的分解,這時可采用共沸蒸餾的方法將水分子除去,具體的操作為將氨噻肟酸與甲醇在回流下攪拌幾小時,可將水分子除去,而得到無水氨噻肟酸。又比如,當分子中存在遊離的或氫鍵的甲醇時,可用另外一種溶劑,例如正己烷、石油醚等等,進行回流,可除去甲醇。可見共沸蒸餾在有機合成的分離過程中占有重要的地位。 (12)超分子的方法,利用分子的識別性來提純產物。 (13)脫色的方法 一般采用活性炭、矽膠、氧化鋁等。活性炭吸附非極性的化合物與小分子的化合物,矽膠與氧化鋁吸附極性強的與大分子的化合物,例如焦油等。對於極性雜質與非極性雜質同時存在的物係,應將兩者同時結合起來。比較難脫色的物係,一般用矽膠和氧化鋁就能脫去。對於酸堿性化合物的脫色,有時比較難,當將酸性化合物用堿中和形成離子化合物而溶於水中進行脫色時,除了在弱堿性條件下脫色一次除去堿性雜質外,還應將物係逐漸中和至弱酸性,再脫色一次除去酸性雜質,這樣就將色素能夠完全脫去。同樣當將堿性化合物用酸中和至弱堿性溶於水進行脫色時,除了在弱酸性條件下脫色一次除去酸性雜質外,還應將物係逐漸中和至弱堿性,再脫色一次除去堿性雜質。 06 合成工藝創新 合成工藝創新是有機合成中一個很重要得方麵,涉及到許多方麵的問題,本文隻是從合成的角度來探討一下。好的合成工藝可以使一個頻臨滅絕的產品死而後生,可以使一個頻臨倒閉的化工企業死灰複燃,可以是一個好的化工企業蒸蒸日上,錦上添花。天藥集團的地塞米鬆,由於先進的工藝,打敗了羅氏公司,使其退出中國市場。本人1998年研發的頭孢類中間體AE-活性酯,成本降低10萬元,當時與人合夥辦企業,投入市場時,所向披靡。現在因為合作問題,企業散夥,技術已經泄密,技術已經在中國普及,而本人沒有賺到錢。另外本人目前研究的抗抑鬱藥氟西汀,度洛西汀工藝先進,相信投入市場會引起波瀾。 最好的合成工藝創新,應該首先從創造性地合成路線入手,如果您研究的合成路線,在國內外沒有報道,那麽就是最先進的,如果成本很低,就會取得巨大的成功,相反,隻是重複國內外的文獻,那麽,你的工藝也就跟別人沒啥兩樣,別人可能比你做的更好。遺憾的是,目前國內的企業大多是重複國外的文獻專利來組織開發生產的,因此工藝沒有創造性,多家的企業生產工藝雷同,商場上互相壓價,最後拚的個魚死網破,多敗具傷。這樣的企業沒有前途,隻能一味的開發新的產品,起初市場很小時,利潤較高,等到別人也開發成功時,利潤迅速降低,最後陷入惡性競爭。這是中國化工企業目前的狀態。 怎樣進行合成路線創新?首先,進行詳細的文獻調研,掌握文獻中各種合成路線,詳細分析每條路線的優缺點,從而設想出自己的合成路線。第二,參考同係列產品的合成路線,有時,可以從同係列產品的合成路線得到借鑒。第三,搜索該產品的中間體,就可知道目前國內外的合成路線。這時就可以設計自己的新的合成路線了。第四,在目前的合成路線基礎上,進行優化,改變價格高的原料為價格低的原料,例如,如反應中用氫化鈉作為堿,則可嚐試采用氫氧化鈉,氫氧化鉀等便宜的堿代替。第五,如果有一部反應的收率很低,那麽該步反應就是你的公關對象,通過優化反應條件,獲得較高收率,那你就取得了成功。當然這需要紮實的基本功和成功地經驗。平常多看一些合成路線的資料對你是很有幫助的。 07 工藝優化方法學 1.合成工藝的優化主要就是反應選擇性研究 有機合成工藝優化是物理化學與有機化學相結合的產物,是用化學動力學的方法解決有機合成的實際問題,是將化學動力學的基本概念轉化為有機合成的實用技術。 首先分清三個基本概念轉化率、選擇性、收率。轉化率是消耗的原料的摩爾數除於原料的初始摩爾數。選擇性為生成目標產物所消耗的原料摩爾數除於消耗的原料的摩爾數。收率為反應生成目標產物所消耗的原料的摩爾數除於原料的初始摩爾數。可見,收率為轉化率與選擇性的乘積。可以這樣理解這三個概念,反應中消耗的原料一部分生成了目標產物,一部分生成了雜質,為有效好的原料依然存在於反應體係中。生成目標產物的那部分原料與消耗的原料之比為選擇性,與初始原料之比為收率,消耗的原料與初始原料之比為轉化率。 反應的目標是提高收率,但是影響收率的因素較多,使問題複雜化。化學動力學的研究目標是提高選擇性,即盡量使消耗的原料轉化為主產物。隻有溫度和濃度是影響選擇性的主要因素。在一定轉化率下,主副產物之和是一個常數,副產物減少必然帶來主產物增加。提高轉化率可以采取延長反應時間,升高溫度,增加反應物的濃度,從反應體係中移出產物等措施。而選擇性雖隻是溫度和濃度的函數,看似簡單,卻遠比轉化率關係複雜。因此將研究複雜的收率問題轉化為研究選擇性和轉化率的問題,可簡化研究過程。 2.選擇性研究的主要影響因素 提高主反應的選擇性就是抑製副反應,副反應不外平行副反應和連串副反應兩種類型。平行副反應是指副反應與主反應同時進行,一般消耗一種或幾種相同的原料,而連串副反應是指主產物繼續與某一組分進行反應。主副反應的競爭是主副反應速度的競爭,反應速度取決於反應的活化能和各反應組分的反應級數,兩個因素與溫度和各組分的濃度有關。因此選擇性取決於溫度效應和濃度效應。可是,活化能與反應級數的絕對值很難確定。但是我們沒有必要知道它們的絕對值,隻需知道主副反應之間活化能的相對大小與主副反應對某一組分的反應級數的相對大小就行了。我們知道,升高溫度有利於活化能高的反應,降低溫度有利於活化能低的反應,因此選擇反應溫度條件的理論依據是主副反應活化能的相對大小,而不是絕對大小。 (1)溫度範圍的選擇:在兩個反應溫度下做同一合成實驗時,可以根據監測主副產物的相對含量來判斷主副反應活化能的相對大小,由此判斷是低溫還是高溫有利於主反應,從而縮小了溫度選擇的範圍。實際經驗中,一般采取極限溫度的方式,低溫和高溫,再加上二者的中間溫度,可判斷出反應溫度對反應選擇性的影響趨勢。 (2)某一組分濃度的選擇:在同一溫度下(第一步已經選擇好的溫度下),將某一組分滴加(此組分為低濃度,其他組分就是高濃度)或一次性加入(此組分為高濃度,其他組分就是低濃度)進行反應,就可根據監測主副產物的相對含量來判斷該組分是低濃度還是高濃度有利於主反應。確定了某一組分的濃度影響,接下來就是研究該組分的最佳配比問題。相同的條件下,再確定其他組分濃度的影響。 3.定性反應產物 動力學研究方法要求副反應最小,而其他方法要求主反應最大。因此研究反應的選擇性,搞清副反應的產物結構是必要地前提。在條件允許的情況下,應盡量分析反應混合物的全部組分,包括主產物,各種副產物,分析他們在氣相色譜、液相色譜或薄層色譜上的相對位置和相對大小。從而可以看出各組分的相對大小及各組分隨溫度和濃度條件不同的變化。對不同的副反應采取不同的抑製方法。 (1)首先搞清反應過程中那些副產物生成; (2)重點找出含量較多的副產物的結構,因為隻有抑製了主要副反應,才能顯著提高主反應的選擇性; (3)根據主要副產物的結構,研究其生成的機理,速度方程和對比選擇性方程,並據此進行溫度效應、濃度效應分析; (4)由對比選擇性方程確定部分工藝條件,並據此設計獲取活化能相對大小和反應級數相對高低的試驗方按。 (5)也應該找出最難除去的雜質的結構,進行(3),(4)的方法研究。 4.跟蹤定量反應產物 在定分析的基礎上,對同一實驗不同時刻各組分的含量進行跟蹤測試,根據跟蹤測試結果認識影響因素,再根據影響因素調整實驗方案。 (1)可在同一實驗中考察原料、中間體、產物,各副產物在不同條件下的變化趨勢,從一個實驗中盡可能獲取更多的信息,實驗效率大大提高。 (2)根據實驗過程中的新現象調整和修改預定方按,使每一具體實驗的目標多元化,即可使每一次實驗的目的在實驗中調整和增加,從而提高工作效率和研究開發進度。 (3)將不同時刻、不同組分的相對含量,整理成表格或曲線,從數據表或曲線中觀察不同組分的數量,各組分在不同階段依不同條件的變化趨勢和變化率,從而找出宏觀動力學影響因素,並根據這些因素去調整溫度、濃度因素,以提高選擇性。這裏的定量並非真正的含量,隻是各組分的相對值。 5.分階段研究反應過程和分離過程 大多數人習慣於每次實驗部分都分離提純產品並計算收率。然而,除非簡單的實驗外這是不科學的。 (1)研究開發的初始階段,分離過程是不成熟的,很難估算分離過程損失,這樣,所得產品不能代表反應收率。 (2)實驗的最終結果是反應過程與分離過程的總結果,影響因素太多,考察某一影響因素太難。 (3)一個實驗真正做到完成分離提純的程度很難,往往後處理時間多於反應時間,若每個實驗都做到提純分離,則工作效率降低。 (4)為降低科研費用,往往進行微量製備,而微量製備的實驗幾乎不能完成全過程。比如精餾,沒有一定數量就無法進行。 (5)反應過程中直接取反應液進行中控分析最接近於反應過程的在線測試,最能反映出過程的實際狀態,對於某一因素的變化的影響也最敏感,應用起來方便。 (6)做好反應過程是分離過程研究的基礎。副產物越少,則分離過程越簡單。 總之,在研究開發的最初階段,應先回避分離過程而僅研究反應過程。可以在反應過程中得到一係列的色譜分析譜圖和定性分析結果,根據原料、中間體、產品、副產品出峰的相對大小來初步定量,根據不同反應溫度條件下不同組分的消漲來判斷活化能的相對大小;根據副產物結構機不同的加料方式引起的副產物的消漲來判斷活性組分的反應級數的相對高低。從理論到實踐實現了動力學所要求的溫度效應、濃度效應,再實現最大轉化率,最後研究分離過程。這是一種循序漸進的、條理清晰的、理性的和簡單化的工藝優化程序。 6.程序升溫法確定溫度範圍 程序升溫法是另一種反應溫度的優化方法。其是在實驗的最初階段采用的。一般采用微量製備,物料以滿足分析測試即可。為使放熱反應的溫度可控製,反應物料不必成比例(一般使某一種原料微量)。 在跟蹤測試的基礎上,采取程序升溫大方法,往往一次實驗即可測得反應所適合的溫度範圍,並可得到主反應與某一特定副反應活化能的相對大小和確認反應溫度最佳控製條件。程序升溫過程如圖所示。 ![](data:image/png;base64,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)
在T1溫度下反應一段時間,取樣a分析;若未發生反應,則升溫至T2後反應一段時間後取樣b分析;若發現反應已經發生,但不完全,則此時應鑒別發生的是否是主反應;若在溫度T2下先發生的是主反應,則繼續取樣c分析;若反應仍不完全,升溫至T3後反應一段時間取樣d分析;若仍不完全則升溫至T4,取樣e分析,直至反應結束。 若樣品d中無副產物,e中有副產物,則主反應的活化能小於副反應的活化能,反應溫度為T4以下,再在T3上下選擇溫控範圍。 若樣品b中發生的是副反應,則應立即升溫,並適時補加原料,邊升溫邊取樣f,g,h等,直至主反應發生。若主反應在較高溫度時發生了,說明主反應的活化能大於副反應的活化能,反應應避開較低溫度段。此時的程序升溫過程應在缺少易發生副反應的那種主原料下進行,即預先加熱反應底物至一定溫度,再滴加未加入的原料,後滴加的原料用溶劑稀釋效果更加。 可見,一次程序升溫過程便可基本搞清主副反應活化能的相對大小和反應溫度控製的大致範圍,取得了事半功倍的效果。 在低溫有利於主反應的過程中,隨著反應的進行,反應物的濃度逐漸降低,反應速度逐漸減慢,為保持一定的反應速度和轉化率以保證生產能力,就必須逐漸緩慢升溫以加速化學反應的進行,直至轉化率達到目標,這才實現最佳控製。 7.調節加料法 滴加的功能有兩個,(1)對於放熱反應,可減慢反應速度,使溫度易於控製。(2) 控製反應的選擇性,對每種原料都應采取是滴加還是一次性加入對反應選擇性影響的研究。如果滴加有利於選擇性,則滴加時間越慢越好。如不利於選擇性的提高,則改為一次性的加入。 溫度效應、濃度效應對反應選擇性的影響是個普遍存在的一般規律,但在不同的具體實例中體現出特殊性,有時某一種效應更重要,而另一種效應不顯著。因此必須具體問題具體分析,在普遍的理論原則指導下解決特殊的問題。 8.動力學方法的工藝優化次序 有了上麵所述的方法,一般的工藝優化需要按以下的步驟進行。 1)反應原料的選擇 反應原料的選擇除了考慮廉價易得的主要因素外,另一個必須考慮的因素是副產物的形成,所用的原料應該盡可能以不過多產生副反應為準,原料的活性應該適當,活性高了相應的副反應形成的速度也就加大了,原料的反應點位應該盡可能少,以防進行主反應的同時進行副反應。以阿立呱唑的中間體合成為例。不同的原料產生不同的副反應從而形成不同的雜質,原料的性質不同,產生雜質的數量也就不同。圖1 為以1,4-二溴丁烷為原料反應形成的雜質。 在該實例中,a 是所需要的中間體,但因為1,4-二溴丁烷及另一原料的雙重反應部位,產生了大量的雜質,給後處理帶來了極大的麻煩。因而是不合適的。但是如以4-溴丁醇為原料(圖2),則反應形成的雜質數量大大減少,給提純及後續反應帶來極大的方便。可見原料的選擇對抑製副反應也有者重要的作用。 (2)溶劑的選擇 主要根據反應的性質和類型來考慮:非質子極性溶劑:乙腈、N,N-二甲基甲酰胺、丙酮、N,N-二甲基乙酰胺、N-甲基吡咯烷酮;質子極性溶劑:水、甲醇、乙醇、異丙醇、正丁醇等;極性非常小的溶劑:石油醚、正己烷、乙酸乙酯、鹵代烴類、芳香烴類等。 (3)重複文獻條件,對反應產物定性分析。 (4)變化反應溫度確認主副反應活化能的相對大小並確定溫度控製曲線。 (5)根據副產物的結構改變加料方式,以確定主副反應對某一組分的反應級數的相對大小並確定原料的加料方式。此時反應選擇性已達最佳。 (6)選擇轉化率的高低。力求轉化完全或回收再用。此時反應收率最佳。 (7)選擇簡單的分離方式並使分離過程產物損失最小。此時優化的工藝大到了。 (8)酸堿強度的影響:強酸還是弱酸,強堿還是弱堿,有機酸還是有機堿。在質子性溶劑中一般選擇無機堿,因為此時無機堿一般溶於這類溶劑中使反應均相進行,例如氫氧化鈉、氫氧化鉀溶於醇中,但是弱無機堿碳酸鈉等不容於該類溶劑,須加入相轉移催化劑;在非質子極性溶劑中一般選擇有機堿,此時反應為均相反應,若選擇無機堿一般不溶於該類溶劑,也需加入加入相轉移催化劑。 (9)催化劑的影響:相轉移催化劑,無機鹽,路易斯酸,路易斯堿。 來自漫遊藥化 |