矽醚保護基是最近二、三十年左右發展起來並得到廣泛應用的一類保護基。所有三烷基矽醚保護基對酸和堿都敏感,但區域很寬。通過對矽原子上取代基的調整可以調節它們的穩定性和去保護條件。由於矽原子和氟原子強的親和力,使得 TBAF (四丁基氟化銨)/THF、 HF 砒啶絡合物和 HF/CH3CN 成為這類保護基最常用的去保護試劑。去保護的過程涉及一個五價矽的中間體,因為矽原子含有空的 d 軌道可以接收氟負離子的電子對。 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hIu9Xmn//5n/n2t7/Nm9/8ZhJSjke322fdug3s3r07V/3WNCU1eGCNjo0kSfR6PSQ55bdFUUQYxZxxxhm0Wi063S6GafLLr3kVb/qVN/Ce97yX7du3UylXaLfbbNlyBoOBRbGkg4DZ2dnc0J+enkZVVUqlErIsH3b/Xp36noWCkiShWCzmPDpI+Tu5J0tV2bt3L1NTUwRBkGdLZsdJkgTHcdI0/lFyQUYMzuaH7O+jPT4Nw0CWZUzTTLPqRkkQ+6f8CyHy88vmlLHRM8YYPz1OeqMnm9Q0Tctd+JZlMTMzwz333MPExESeWq6qKpIk5bvCbDd5KPi+n09KkiTlu8vMyzTGqYtssXyiRTMOAhgZj7Is47suw24X27bx49TTYZomnu9RLpWpNBqcffbZvPOd7+S2227DcZxcH6fdblOrpYRjRZHo94d4npcu8q6FbQ0wDJ1ERDSaddqdDpBmY0UiwfFcJiYn05pWBZ2iWeS6666jVqvykpe+GNtJU+7T0HA5FYw+htfwQMg2HZknClI+XbVaZXl5mVqtxqOPPsrCwsKa4zSbzSc1vpMkOWiL4/hxz403BWOM8dTFSW/0+L5PHMfU6/V8dxTHMa1Wi5mZGfbs2ZMLgvX7/Tz+3+/3n1SV5SwbJ3vMJtJqtXpMxM3GOLGh6HpaWiH08tBGpdFgamqKWsnEdV1KZgnTMOn1exDH1Go1lpeX8/CVaZg873nP47777kMIwYMPPQikxsL999+PqqpUqtXc2xTHMZ5n8ztv+y0++1efxQt8DM1gMBjQbrdZaq3gRiGdYQdVV/jkJ/8CRVG4+uqraTQa9Ho9bMvjWDgnn8jgyZ5P0+jTsE8W/pucnKTb7VKr1bAsi/PPP59169axuLjIysoKuq7nHLssTPRETZblQ7bME7T/3yeS93aMMQ6E1Qb8z9KeijjpjR5ZlvNwUpYyXqvVciKxaZp4nkepVMIwjFwErlqtPqnsk0xZOUslrVQqmKbJo48+mu66V02AB2pjnDrY/35LkkQ06j8FrYAmaWmIdThkMBgwtFMSrmCfJygKQx599FG+9rWvce6556Yqzwt78xT3r3/962zdupVut8/v/M5vsbS0hOvaQMJg0MdxLVRV5ktf+gLf+ta3KJfL+GGAG3gUi0VqzQaNZg1FUahX6tRqNf6vF72Qs88+m7/4i7/gBz/4AU9/+tNH5358rt/q65htYkqlEoVCgX6/D6SZcZlRMxgMKJfLKIrC1NQUkBpLmRbPwdpPM7E/lSf6McYYI8VJb/RoWrqQhGGYGyFJklCv1ykUCgwGAwzDYM+ePalbv1hkaWkpndRH7vKDIcvwyGprZQqyT9ZoGuPUhjryVLihix/7qJpGoVajVCqhyjA9vQ5dNVBUjXXr1lEoFdiyZQtRFHHppZcy0Zxgfm6el73sZdi2zTvf+U5URWF+fpZ77rmHpz3taXmWYrVWo1qt8vDDD/P3f//3nH/++QRRGvo1dZOhY+fjIYoiesMepmZQq1f4sz/7szxDyrZtQEY9hhnTBzJ4VldFz4i/maGScV8y9eaUi7SFXq+Xj9NKpXLYO9mMY/REf48xxhhPLZz0Rk9WQTnz9oRhmIuSDQaDXMgs0zORJCkPaz0Zowf2ZYhJkkS5XMbzPGzbPiK1h051nOju1UN58+KRIKAkSRiKAbIMQUCv10NRZIrFtG+Zpo5leZQKJbZu3coXv/hFrvkf1+THOf/88/n0pz+d9/OtW7fywAMP8Mxnnk8iIhzb5pFHHkSWZa699lquvPJKJicn02skZGIkXNdnYmJiJLUQUq1UEaQh4bPOPIurr746HyOmfmz4ak/kEc2e830f0zTzUHIWxs70uDLvqyRJLCwsMDcqtzEYDAiC4LDDW0/0urEn99TAU33+earPn0f7/A70Hkk8Fe7MMUAURTnpMMuSyHDvvfeydevWXBysWCzS6XTWpBgfDClHIg2R6bqeV50GTkoy8+ouc7Qn9sPtnsd74RFC5OeQGeBZFhICIt9FNQ0CEmJiZMdDS1J+yKDTpjQ/Q9+1qZeqtFZWmJ6YBxk8YHnYpq4VqJgmlu2wvLzMls1bANi+bRunn346YegjyQJJgKJK/M//eT1CxLz//X/IZZdfxlvf9k6e+ayLmJmeI4oTOt0+M5MT9AZdatUSge8iyQJT0bAsh1qxSRSBEitYjk1tooSQ0nt0LK91NoFZlpXrIGWkbV3Xc+Ov1+tRq9XwPC9PZigWi6xfv57t27cfk/M8HKzOWEuSZE3/Od59e4xD39/jfY8Ot/8d7vsPtfE/2vP7gY5/0pf5zupcZcJfkHp7bNumXq8TxzFPf/rTcyEz0zT3ibw9iRuSZY+USiWCIMgJzJla7MmI0RqHkBIEo7ADADKsvmQSQMLaqyiven2G5AC/y6PPkLIPG71P7HcOaZPEvscTCerIKA5CD1MzUYslgsEQJUmoNicIk4RaqUaSxExPzdJaXGBydo4g9jFklZJp4nouuq6zZfMWHDeVSVi/fj2e56QaN7qCpqj88L/u4f777+fGG/+MVmsFSVKwhxZz03PIyOzYvYstm06jbw3T8BoyqlFEAmzXRlN1ZFUh8lyErIOS35bjgiyMbFkWuq6v0dbJNLjq9XpeHkZV1ZTD5Pu0Wi0mJyfXyAgcCJnx9ETYf4443ovcGMcDCZKQEVL2eLzPZ38kQHZ+a+fLfD4Wa+fUOJ+7JZASlERGIgEh56/JvudB51zBqsk+GX1e9ghrV4L9D3Sg1x/ou63G/q/Ljr9qo36qeHoOhV6vR6VSyV3Tg8GA2dnZtCDjcIiiKLmg2WrJ+sxFnumBVKtVWq0WYRgekYKmRx/7GRmjv4RImyyD43iIkTaKjCCJIlzXplgpEsvgBz5FvcCgN6BWbRD6PpppEkU+kYhwfJdSpYzreph6AQkNEYEkBIkIMEyFOAzxXZtyrYJn25ilCo7vk6BgGul1DIKYgq4QBgFJ4KfqtZrO0HUoF4rYnoumKOha6p1bXFpkZmYGeOKBeawWqdV6ThkXRZIkEDGCtRNIOrmM3ihLCGT2P8tMc1lCQJK++ImGsu0MqVaqfPFLX+Ctb30riiJRKBTo9WxQJf7X/76J/3bZZUxOzSCEwPd9KqUSURyijbRgUjK1POolo4lFSLkRmn2vY41DTV9C7CsuWiwWc42bdrudCxU+lbHa0yPEWJvneCPrb5mnUVEkAt9FVw0SYohB1jUGo0zgTE4BSWF5eRnTNKlWq/kGG1Lh0swLnBHwLcuiVqshy3LupVQUBdu2MU2TOI5xXRdVTTWeVlZWmJ6eJo7jNMQ66idRHKEoEt1uH72gE7ge9UaTfq+LWSoSChlVUsHzKZXLuNYAtWjiEqMqGiAzGLaZrUyASCCRsIYDlIIBiky71WXd7Byu5+JYNrVamgmdjHSuFCQkVUmLLE828bwAzVDxvIBioYwkIArA8108z6HRqKGoKkJESDIkCQhiFDkdp2EYj7xHMkkSgBSjqQqdbo9mYwKQCcMYISSSGDRNTbNMJZAkASQnP6fnUMgECDNSoyRJrKysUK1W2bt3b87TkWWZVquVd8RerweQy8Wbpkm73U6LQuo6pVKJTqdzPL/aYSGR0hZFUCyaqXrw8iJIEr7vUqqkRO1YhCRSugTX6nW67TaaqrGwezee56DpKtVKBce1QJFQFBVVkUliMIzUm7a0tEgUB5RrJfrtFWQFOp0VDEPDNAp0rSGdgYWqKcSkC4FZLBEEaZq3aZosrixTMAsIScIL03s6OzN7HK9gikMuyqPHNTstZISUNg5g8AAoo3Yoz5aiSFQrVeIk5ld/5c20Wi1s2+Whhx7h1a99FZ/8xCd586/+KvOz86iKNFJs9pBgVNJCGnnzRsJ+QJL9SE/9Kt8rKyv4vk+1WmXLli04jkOr1WJiYmLMuRvjZ8K+MZ1AIpASASJGlhVkTaG7ssyVV17Jxo0bWbduHX/5l39JFEV8/etf58wzz0TX9Vwss1gs0mg0aDabbNmyhYceeghN02g0GsiyzK5duzBNEyEEn/zkJznrrLNQVZWZmRnWrVvHtddei6IoNJvNNSKeURzhei6Q8Dd/8zdsOXMLs7OzXPrSF+N4NmapwKtf+xpm5+doTk3yvve9HwTcdNNNbN68mav+xwdwCbCFQ73SGH3XhJXdj/GsCy/gxhtvxPN96vU6uxf2YhgGzcmJtA6ebUOcoMkKN998M/Mzs8zMzDA5NUm1VkbXDTafsZnzL3g6npeqt5crBSanJgiCCNseIMkyvW4XWU4jM4I4F1ZVFCVXTnddG0E4MmgEn//850eZ2AVe/OIXr7pp+3495Ud9tnOSJCnX+Wg0GrRaLer1Oq1WK1dMNQwj1VTxvJxHkFXPhpQ8mlXFHg6HJ0h4S+Zg3SCKUgPCtm1e+MIXYqhpyr+pKZTLJRoTTarFBrKiIUkKW7duZWlxke9973uceeaZqKpJsVpkamqKRqmOYRpcfMkLcmNTNw1mZmYoFIq0V5ZJkoRvfvObPOtZz+Jzn7sFSMmimqYhSyALsAZDPvOpTzE1NYWmaZRKJebn5iiVSxR0naJhMD0zzfLK8jG4fscfB/SwSAmSLOgP+sRJzNLSEp1uh0q5knNf4jhmfn4ex3FwPAcJiXKxTL1eBzgpsg9nZmZyovjDDz+MYRh5ja6T4fuNcZwhSWijdcG1LJIwpNFs0ul0GAwGDAYD7r33XhYWFjAMg06nk3tt1q1bl3tmarUanU6Hc889lx/84AcIIVhcXMz1paampvjd3/1d9uzZkxYWFgLbtrnhhhtQVZWdO3cCKYfUdV1URaZgGliWhWEYowoBbp7VmCUAeL1hvrb5ts3U1BRRFPG3f/u3fO/730OTZILEI4ojPMehVquxd+9e9iwuUCmlIrzzc2ntyXPOOYdh36JYKCOPPqNer9Nut5mfn6XT6Y+U5mUsy+LeH93H2WefzcrKCkkMux/bQ6FkUhqFoOuNRv6dJJScpgLkYelyuYw0KoLsem6uz7X6NfvvO095owfSDBBZltE0LdfpaTabBEHAxMRE7gFKaxr5eaii0+nkxEJJkuh0OrkOiOM4T5oX9FSGaaYGXbNZR5YhTgQzs5OsWzeDHySpu7Kkg5zyH6IwwXVder0eS0ttNE1ClRV0Xacx00SEMffccw/nn38+O3bsodvtIoRg7949TEzN0pia4uabb6bf7/PVr36Vbr9LuVDENA08P6LbHVAsFqlUKkRhmBba9FPXrO84FCsVJFVlMBgcs/pJh4MjqeO0fzo37AvBzs/Np4ReP90hTU9N8/nPf56LL76YqYmptPRCknpuLMuiP+wzHA4RB/h5KuFQ16/b7VKpVCiVSnmWlaqq9Pv9p3xoa4ynPnzHSQ2fUU24KIpgVHbmmc98Jnv37uUTN93Ehg0b8H2f0047jXvuuYd+v893v/td+v0+3W6XRx55hD/90z+lVqtxxx13EIYh09PTCCG48sor6ff7vPzlL8e2bRzHYfv27QghePnLX45pmrzjHe/gkUceScVMSyWCMCARCfVanVdd8Sruvfde3vjGN9Dv9+l0Ojm/9RnPeQ7f/95d3PBnH8cwTUCm2+2y8tgCH/jAB1huLaPKKkKIXNtq06ZNadWByKfZaAJQLBZJkgRVVdMNxaiOnG3bTExMcOedd+I4QxYWFrAsi1arxTUf+TArKyvcf//9rKy0WL9hHUEQYVlOaiB2Owyt4Ugig7xWpeu61OtV4jhGCMFKu41hGOi6zrve9S727NnDa179GpaXl/cZPPnUKI+NnqyjCiEoFAp5loQsy+gjtdzhcEgQBDkRMooiHCe9MbZt55yeLB4LabhsddXmp0oK40+Lbq+L5zvEic/37/wPwtBi27aH+OE9/8lrXvNKnvmsZ/LQIw/j+T6O47C4uMhpZ5xBe6XFlk3raa+0WFpaYtu2bdz/o3vpWwOuvPJKdu/ezZ133snExASDwZCJ5hSB6/Lgffdx5513cs4553DHHXfw72T3kqgAACAASURBVHd8B8dxcF0f01BpNqtphpyTDu6f/OQnDCyLfq+PGwQM+gN832f37t1UK9VDf8ETHPvr1+xvLJVKJTwv3anJskwYhmmott2iVChRr9Xz92Xu8UKhQK1So1FrnLD9NkMcx2zZsoXt27fTbreBlF81PT39pMvMjDHGE2E1x0o3jHzsLS0tYds2tVqNJI557LHHcF2XvXv3Ui6XKZVKzM7Oout6Kgpaq/Hrv/7rbN68mUcffZQkSfA8j89+9rN8//vf58orr+SrX/0qxWKRIAhyA+Dv/u7vePe73803v/l/uOWWW9L6faRE/iAI8o1MFEXs3bsXIKdoaJpGfzhgy+ZNdDs94pHWlaZpXHXNB7nvu//JF7/4RWIRp7X6FAVJUuh1B+iaSbfb51//7dvohsnWrVv5ySOPMD8/z9TUFB/60DX4fsjKygphGBKGMZ4bUKvW0FQNQzO47LLLcD2bhaUF6o0GYRRz+eWX88u//Mspr7Bco1KuUK1UueKKK7j00kuJ45hCoUCn08nLRhmGgSzJBEEqRwPpmjs7e2B6wylv9ERRRKlUwrIsYJ81GYZhvhvMOshwOESSJOr1ekrqlWWq1SqKolAqldi9e3ca0xwVGs0k8k/chSOhUa8RRQErK8uYpk4UBegFnUqljG0P6XQ6zE+tQ5X1VNiuaCLCVCE31XuJsfoDphtTTDVTj8Lv/OZvoWsa/f6QbqdPvd7ADwMU3eAHd/+QUrHC9df/CdVqlW3btlEuFikUDFwvTIlto1TlXj/N2jEMg0Skk8RKawVZkpmcmCSKn5zO0omOg5VqkCSJRr2R6uuM3MCqoo6yDB0SkfJzDM3I90BxHGM5Fq7vPo64uRonwuRRq9W4//77mZqaYnZ2Ftu287BWuVw+zmc3xokOdeQxIY5J4pggCBAj42FqaopHHnkEeVSId3JyEllOQzuZqKYsywghcF2Xq666ih//+MfMzMzkXMXbb7+dTqfDxz/+cWBfBYAsKUKWZT7ykY8gy3Dbbbexc+dO3vve97J582Y2bNjAG9/4RmzHTjcytRqGYaCqKt1ul26nT7VaRwDFUgVFTz05iiTz33/9N3j1W97ERz/6Ub7+9a8z2ZzAt2xKlQqFUrpGNptNfu7i52NZFtu3b+f5F1/Mjh072LVrF1dffTW1ZpPJyUlUVcWyLOr1OkNryPLKMksrS/zH97+HoqqcffbZaJoyKpET4jhOXlbG90PCKCQMwzzs7jgOzWYzl4VRZI3+IE02qlTS8H0cxznvNk3KEQiR5xif2shSWyuVSs6ahzSOWKvV8H0f27axLCuvlJ6x6HVdJwgC9uzZw6ZNm3KeT+bq8zzvcQvFiWP8pOfZ6XYQQjA3O4eqqthOujvuD7ooqsz8/HpWum16/R66boIAZ2gx1ZwgCkPiKGB6agI/chlaA1RJ5m//9u+ZmpyhWq1SLBbZtv1RTLOAZVlcc801vPCFL+TCCy/kOc++iD/6oz/iP+++G0jDZ4PeEJmUqzE/N51nN8hSGrYoFAq0O20WFheetLjkyYjV2kCQim+GUcpH6/a66JpOsVBElmSSMAKRkMQRYeBTNEyqxTIlo4AsQEoEsiBvkhAnzMTRarUol8v5GC4Wi3lG1zi9fIzDRTTy5qMoyCO+TEaytW2bLVu2YA2HeUjJsixe+MIXous6U1NTuZjlmWeeyc033wzAu9/9bgqFAsvLy3z729/m4osvZjgc5gZS5pHNDKd2u821117LPffcQ6lU4vrrr2fPnj3s2LGDz33uc5SKJXzfZ2ZmhihKicPNZpNms4nv+ywutxBCsLBnL67rUi6X0TSN9//h+1BlhU9/+tP5d+r3eriuj+N4aIqeb/KHA5tup49pmtRqNRRd58H778e2bbrdLq94xSsol8s06hNs2XIG55zzNN7xtt/jqquu4tkXPYeBNcQsmFRqVVzfQ1JUqplHSjVyB4IsQ5JEQMpZDIKIQqGQauppek5FURQl5z7tjxNl7jpqKJfLI4vSR9O03IPjOKnGiWEYNBqNXN8jaxs2bKDX69Hv91m3bh3btm3LOQRZ/DOLm544hs5+kBKq1SqVcplOt4PnO9SbE9jDXpp9oCgMLRvdKFCqVJGldPeR1SIzVI3TNmykUKiwYX4dW886g2ZzkptuuolfedObeMPrX4WiaGzecjqtVovt23awY8cCv/CSl6JrJn/8x3+cX1PPC9DUtIJ9JgaZuY+bzSaVaoV6vc7MzAxnnXUW/X4/v/6nCg60iKuKShil8gmyLFMpV/LXhdE+jRpZ2pf5kSaiCxzXWePpORExNzdHkiQ5gTP77qqq5gbhGGP8rMg8PUkYQhyjmyaFYpFSqcRgMMCyLOQRxydT6W+328RxnFMjMhX0K664gm63i6qquYTK3NwcpVIpF93MakUCeQRiYmKCbdu20Ww2GQ6HeemlUrGUellsi1KpxI9//GMMw8i98Lbnpn+Xq5imytz6eRqNBv1BF9d1OfeMc7n++uv5j+/8Ox//+MdRNZNSqYKq6GzafBor7RYSUK+lxYzvvPPOVIpDlvnxffdx9tOelq+de/fuzedj3/dT54Ik8e1//w7FokGxWMTzUm5tFEUMh0OiOEGW1Zx+kpV4ykSEZVnGNEz6/SG6ZpAkIEmpt6c/6D6hxtYpb/RA6plZXUMre261rkocx+i6ThRFBEFAp9NhcnKSqakphsMhxWKROI5T7RhJyqu7Z++HA0tiHwqZvH6v18v1OrJOn3GGjjSy05KQ8pi1oiiUCiUQSc6DkmWF4dDG8yKU0QAkAaNSIo4CAs9LNWQS8D0P4gTDMNj92GM8+OCDOI5A0SSGlk2jPsHHPvYxJAle9KIX5dkNqqryhS98ASkRhOFIlVbX8b10dwGpFyOOY+IgyAdItnhnP8cLx8qb8LhK3+wzXtboA4nUkE1EkpOXFUUhTuJ8hxQnqXK5YRhrSiys/i65pPthFs89FjL4y8vLa2pxGYaB67p5osGJatCNceyxeowpigJxDJk6tqIQBQGMMoFLpRKapqHrOuVymV6vR7lcZseOHSRJguM43HHHHQwGA84991yuvvrqfEFXVZVisciePXtyfg7s23yoqpqvB1lB3ZWVNnNzc+nnlMpEcYSu6Xn2a6VSyevqlUolwjBE14yR7EoIMcRhhO/7TE9PExDwG7/2Zi699FJuuOEG/vPOO/F9H8/zeGzXHuqNCaI4JoxiisXiKAusQBILzjn3XEgSgiDC90MW9i6xvNwiiiIsy2IwGPDd73+f733ve7zsFa/ADXy8MMByPDSjgEhSfap2t0MsUo7UWWedhSRJ2LaNYWij9TWVQRGIXPssDMM0W821RiGzdB1Ol3ZpbPQ8GcRxnHt+SqUSpmniOE5+kZ/3vOfx0EMPpe6/fh/PS6tjr87s+lmzc3Rd57HHHqNerxMEQZ5dBoeW+D58yCOjSxoJLcq4joOiaHnJDUXR8MMIL0yQFDkVZXYDfDdN619ZWcEedLAGFsuLyzzwwAN88/Zvcscdd3D55ZfT7VpUyhV+dN+93Hb77TQmGmzatAXdLDA3tx7f9/nm7f+Hhx9+GF2TUVUZe1QzrVIq0O22abVaOLZDlKS7gfvvv5+ztp6VeiqOc8bRU3lBPVTfPBnCP47jMDs7iyzLuTcX9o2dp/L9GePEwRONlSy5JQtLqaq6JnHmwgsv5B//8R+59957+b3f+z127NiBLMuUy2X27NnDK1/5Sh566CFM0+SRRx7JxSoty8oTanRd5xvf+AYvfemLc7FcWNvHM3HL1cVwkyRhYXmJ4dBOleGV9LWGpuN7Lr7vY0gGf3L9R5EFvPWtb6VYLFKu1TGKRR57bDcI+XHfffXfSZLg+V5OMM6LA+smZ5+zlbf97u/w/bvuxAv83KDMigcrssbU5BS9Xo/p6VkeeughFhcXU5X1UWKG67lIkkTgR7iumzskMg2k1eM7+3Vs9DwJyLJMpZIqTS4uLiLLcp65JYRg9+7dbNiwAUmSeMYznpELRWW7gScqRrh61/BETVVVnv/85yNJElNTU9TrdSYmJlhYWDikRP7hIe24mQcsI39KKKiqRuBHtNtd4gSKxTKGJuN5PrGfIElKWucsjnGsAa5j4Xkug0Gf6ckpXvKSn+e1r30td911V6or4fl86Utfxvf9kTct3UA1GnUqlRqd5WW+8pWv0O0NkSUoVapUyxWiIMz5GWEUIkgLTc7OzDIYDvJUxzFSHLBwpzh4k5EO2o7EOR1NoyvzhmaKt1l4OvP2ZHgi4+dYeKLGOIFxiD6aEeczr2JGmcg8Frqu87KXvYz3vOc9/Ou//itf+MIXKJfLuK7L+vXrueCCC9i1axfXXHMN69evp91uUygUct5NtVrlU5/6FDt37uSSSy7JVcZ7/R6yJOcekKytruMmhGDDhk1UqyUkCTw7wLKs3IOrqzJ9u8d5Z5/HH/zBH+C6Lh/84IcYDNK5dfOmDaMxOhJRlVaZE0IGIefzca1WQ5IkhkMbRUk3Hrqup7wkEdHutalUyjz9/Gew87FdaGYBN/BJkvQa9no9fN8fZWQlqIqazj9C5jff+tv8y7/8PxhGWiuzVquxtLQ0uj8Jgjj1HCWAGBs9h0TmXckmy+npaVqtFoqiMDMzgyRJ/PjHP84nwW3bttHpdHLrPrNssxaP5Ll/mvbv//7vuViVZVksLS0xNzeXiykePUgoskYQRsRxWv9EllVEkup6l0v1lBEvpcUIDN1AMWTQFaREEMcxRTMlmZmajqaqKLKC50VoqoFtu6nmka7x9X/6J55z0UXcd999JElAEKTKuffddx/rTzuNT3/60xQKBcIwot9u0+/3SZIk373LcuqVyhYyVVWZmpw65Req/UN7J4P35qdBo9FY432FfYZ8lt57oD5xKvaVMQ4f+4+v0qqyEpmysm3b2LZNqVTKM5U+/vGPc+GFF/Inf/In/OQnP0mTNgYD3v3ud3PJJZdwyy23cNlll+VenKy+4+tf/3o+9KEPMTs7y9ve9jaAPCzd7XUPeb4LCwsMLB8hyItxu25IEAQko7p/3WGXP7zqKp7znOfwV3/1Vzi2y9TkDLsXVlZ97wN8f4l8g7G0tEQcx1QqFUzDZGlliR/cfTef+aubefazn83c3ByDUTiq12px66235uTlqz/4YX70ox/liURxEmMNh0iyzCc+8Qm+9rWv5eM1K/VRKpXW0D/2cRPHRs8hkSRJHgvNiGiZ1dputxFCMD8/z969e/P6PpnOT7vdRlGUNe1gXp8n2ulu2rQpjb/qek5SC4LgmNT2imOBomiYRhkhZHwvQpI0NLVAszlBrdHEtl28AIZDm9CNIEjVfqulMqZZQFM1kCSKxRJhEHDXnXdy06du4qKLLkJWNe78/n+yd+8i73rXe6hWawwHAzQ1VfScmZ7iuuuuw3c9bv3SX6PpKoah0W632bhx44jdr+WdOlPjTJKEwXAwXrzgcbymkyV09WSxmkiaTYTD4TD31GY40UnbYxwn7D+WVs3fiwupBk1aGiElEU9NTa3R27Ftm1arxTve8Q5kWeZd73pX6mkZUSRuvfVWKpUK3/rWt2g2mxSLRdatW0ehUOCrX/0qkiRx++2353IrmQJ5sVhMR/5B1pdavU6plJKAfd9ncnI6lSbxA1zbwfZtapUag26Xj3zkI+lm20vrUa6fmzrINUkfnnbu09m56zEuuugiqtUq5XKZeqPOxg2n8Qu/8GK8wYB3v/ddxHFMuVDmlf/tMmRd57ff+lYajQk0Vefhhx/OM31FkuA5LqZp8NCDD3Lffffxghe8MOeZ1ut1XNel0Wg8bp4T4ggZPSe7+ze1fNP4ZrPZRFXVXLRQ0zS63W6eDpgx72VZzpUoV3tsVrsZn2zLqr9nBDJJSmuB9fv9Y/L9kyRBkVNukucFqKqOJKssLq6wfduOfICZOtRqJTRVBT015pZWWlTLdQpGHUMrUzRMGo0GL/r5n6daqvKe97yHclnnmmuuIUkSLr74YpAkKtUqC4sLqQhhEPK0pz2NWq3Gl7/8ZeIowSyVqFar9Hq9nKTmeV6ulB0nMeVSmWqlelCdmVMNB/L6HG47XBzt+aPVauWh5xe84AXMzaXSC/PzaabK6vNY/TjGGE8K+1wcB/x31p/a7TbdbpdGo5HrvWVk5kKhwOTkJG9605v4xV/8Rb7xjW/wuc99Ls/Ump6e5oc//CF//ud/DqS8mMFgQKFQ4LrrruMHP/gBGzZswDAMer1eXvza0I3RqT3R+FXo94coCmgm+RozOztLr9fLN/dhGFAplzh961be9773USgUcX2PTt9Gkh5/CVZfip/85CfMz84ThuGa7GdFUTBNk2/8v7dzySWXIEkSbuCmqfuf/xzmSEPr557/fG677TZ+4RdeTLlcJgiCnIz9rne9i7e//e2YpsmePXtQFCUPmbmum2dr7kskStvRJIWcFIiiVAfANM28BIWiKLkic6ZuCal2TBAEBEGQ3kTXzV3oPyuyrDDTNOn3+2tIcUcGa6us7w9Ny2qdpJwI3TBJooAkhjPPPAt7+05WVtrMTzaQBdi2R1FLjaSJRp2h20NOQDE1+oMQTY+Zn53nf//5J/nFV76cbT/Zw913/xcf+tCHmJycxLYsFEVmdnaWOJEwdJXzznsaL3jBC/iXf/4n7vre93nes5+JiGMsy8qJqeVSOkgyLRoZcu6VEGLNgp/FrE9FZBldTxUcysg43Ps0OTlJr9fLxUbL5TK6ngpp1uv1XMr+QJ/zZAygU7UfjXFg7N8fZmdn6fd6TE5OcuWVV3LZZZcxOztLEAR5mZwsMysIAj7zmc9w66230u2moSlZlnPJhd/+7d/myiuvBMg3eEHg5Vo5e/fuZePGjQghcDwbSZIomAdff2ZmZrCsCD+IqZRrvOq1r+ZZz7mAmS3rcCMPXVNQUUn8BEWReO2b3shr3/xG+iFEB6hdt+brS/CGN7yBt7zlLUiqgqprRFGAqmsgy9iuAwoUjCLLnRbTzWkKkwXe+LrXc/FzL6FarlA0DUolg+uuu45KpYBZKOB7DrfddhsXXHABF174bAYDi8nJydSztrjIxMQEmqYgRPy4DdpJYvQcrGjg4RsGURShaVquopkZNbVaLY0vjhbfTL5bVdVcEyXz1sDjB8O+m3DwiTXLEqtUKnnoZvfu3axfv35NsdMjDXlVzZI4FvtSNAU4jse60zbx4Q9/mNgoMNms47mCoikRqiAVNX79N3+LN/zKGyg3ykSRj1oqEwYxqmIiyTIkEMWwccM6VpYXsPoDNEVHLSokcUgUJqiaRgJ02h3++su3EHoRCmlM9y3//a286nWvB8McVRMmH+CVcoUoDNA1nTAK84yHU2uBkknHxv6PT61rcLQ9K1lquizLNBoNXNdFlmXq9Xq+cYERcXv/8xo9IQ5Uz/WpYzeOcdwggxSP+om86nHfurO6f1uWxczMTC6bkEmPZBvqcrmcz1HNZpN+v5+Tcuv1eu7h8H2fLDVb05TcgMrqe0VRRLFUXKvDlcmQjBTtpSQVHfWsIZos05xQcfseztBm45bNLHWWaTQn8HwH1dBRDAnfckHSMEomgedhFs3RsTOJkFTSNrsMkIr8FqslhgMLRVPzzLNSqUSpUCSMA/zQo2gWAEEUxSiyyqZN6wiDGNeygYTJyeYocUdw3wP384UvfJG/vvXLRFFEs9lkMBigqmqaah8EaJqWRyEkSRp9cRkh0gvwMyFJEhHHsfA8T8RxLIQQYjAYrHmN7/ui1+uJJEmE7/v588PhUIRhKPr9vgjDUIRhmP/P87w174/jWCRJIpIkWfPZ6eeHIggdIUQgHLcvotgVQoRi12PbhRCh6Pe7wnEs0et1xMrKSv7+7PNGpy327NmT/y8IAiGEEL1eT0xNTYn5+XmxY8eO/Lv6vi927dr1s162pyDi/dpaZNc6u95xHIpk1KIoEkEiRJAIEcVCxJEQyaiJUDzuyfQ4Im1x2uIkbfnzqz4vGR03a/GoJVF67CSKRZLsO8bP0o4VVvdxYE1/PnqID/B48Pu9P6Ioyn9PkkQ4jiNs2xaWZYlPfOITolAoCFVVBSBM0xQf+chH0n4RBCKKIuG6bvrJcSy63a4QIh3jtm0LIUT+/zAMhed5a+5/NhesrKyI97///aJWqwlAGIYhZFkWv//7vy+EEMK2bbG4uCh83xevfvWrxfT0tBAinT+y87dtWwRBkM9DjuOIOI5FEHjCdSzh25bwh0Pxhc9+VhQURZQ0QyiSLJAQ5XpNoKoCXRd6uSw6g6FIhBBBEK0536MBRlN0HMdr7sUYTw2k60UsRCKEELFwLFs4jiMuu+wyUa/XBSCuvfZaYVmWECLtdxmGw+Fhf342Jz9RGw774tZb/1rUahVRKJni2c++UCQi/d9rXvdaIRtFoZdq4n1/+EfCGqbjrd/vCz8MRDqNJyIWa+fkOEmn91Bkc3eyau5eO4eLgwyLZHT8x7d9x/aDSCRCCNf3RCKEGNqW+Oj114mZmSkBiEKhIABRrVbFtddeK2666SYBiEajIc4//3wRRdGqlogwjMVhu0IMw8hjaJVKhSiKaLVaQJqSVigU8vhlZqVm1VhVVcVxnLwyayo6tC+V9Ml4MRRFRhAjy6DIEkNrwPr162h32lSrZRRFoVqtMjk5mVvWnufRbqfuwyiK8hTBTAOn3++zYcMGtm/fzne/+92cSJxVcm00GgRBcNTEAY8vkoO0FGLUJEmgCFCyTbGU7oqFBIkMiSQjJAVB2tbspdMEsOyBx/1j9Ozav0afL2XHlp9CgZoDQxxXjoh8gMf928EhSVKuHmvbaQ2fpaUlLr30Ut7xjnfgum4+lj3P46Mf/ShTU1Ps3Lkz19vwPG9UGbme1mcbjaPBYJCXCvE8D8MwcJxUBTqrXwdw+umnc/311+fhqTAMaTab/Omf/ikXXHABkiQxMzOD4zj0ej0uuOACLMvK55HHHnssV1rP+HaFQgHHcVIvbaGAbpropokI0wxLWZZBJJQrFRzPBZFQbTYwTZOdO3fi+2Ee+h3j1IWmaSQJo6QJiUKpmCet9Ho9NC1NyMhCWFmWKRyb2m/lcplut0u/P0TEacRgYe9iqndTraAimG7WKRZNbNdCAIViGUXWSKIEeTShC7KWIi9Jkz+z/+MIB3Es70t2378JZFLNDE1LxVIty8JxHUrFEu973/t54MGHSEZyMb/0S7/EjTfeyPvf//58bkmS5ADUkgRJEofv6cl+z3ZuYRjmuzfXddd4eMIwzN8jRGolW5aVP2bHyHZ42WcczNOTenm6IoptIYQnhAhGLRQrrQUhRCxseyh++MMf7nfOQoRhLMIwFEmSiG63m++k+v1+fn7Z34PBQAyHw/wcoyjKfz+xcaDd/76WJNGatv9OYp+H5vi0w/HyHAtPT9Zvj4+n58ghO3/P88R73/teIUmSePnLX77Gu9tqtcQVV1whNE0T5513nrBtW7TbbeG6rkiSRERRJOI4XnMthEjHWTYHJEmSe39t2xa33HKLkGVZXHXVVcJxnHzst9tt8bGPfUwA4mMf+1g+t/T7/Xz+yOae7Fp7nic6nY6IokgsLi6OxnssAt8VO7f9RIg4Fp//5KfEVLkiuksrQiRCOJ4r+q4thlEoeoEvrCDdATuuL3q9wdjTc4pjdf/3fV90u12RJInodDpCiLTPZf3e933h+37eV1avhT8r9p+f92/ZPN5urwghYrF3724RRal3avfuXcJxfdHtDYTj+iKKhbAdTziuLxKRemIONX+u9cw/vh0K8ciTdLCWCCGCKBSWYws/DITl2KLT64qBNRRRFInXvOY14jOf+UzuRfM8T7Rardybm7XM43PYnp4sM6lYLDIcDlFVNd/dZZoC1113XVonwzRzUvD1119PkiR5hXPDMDBNM5e/z7KdDvn5SVr6QZGVvF5QEAa88/9+J89+9rOpVCqUShVe+tKXcsMNNxBF0UjjJeXjXHrppZx33nmpSN7IAq9WqziOgyRJdDodoiiiUqnk1WLFKIYpToFMj4OpbT659x9eG+P4ItOWyoQwP/OZz3DjjTfywQ9+kH/4h3+gUqkwGAxotVpUq1W+9rWv8YlPfILHHnuMG264IRfqtCwr1Q4ZZThmGShAzpMrlUoEQZB7lorFIv/1X/9FkiR84AMfoFAo5N4hSZJ4z3vew3nnncfdd9+N67osLS3xlre8hec973m5t6bb7SJJEvfee2/O61mtsZVl/W3cvJlht5vPU5kGlmmYFM0iuqIiSRKaptHudImiiGq1ctzuyxhPDVQqaR8YDof4vk+9Xs/TxW3bzvt5VjBU13UkScp12442wjDM1zJIif2ZYOL8/PxIgqWCaerIMhQKRpqyHiV4XnDI4x/t7M4gCIiTGFVR0wLJo/GZiTDKsszNN9/Mb/zGb+yruq78/+29e5RkVXn//TnXOnWv7q6+zPRcmIFBEA2Kt/gi6AKiRIJJvMSAqFFjgkbRyFooLpcXolETE3SF12hQ/PmqvxB+0VeMLl+ShRGDiASDBg0yMAPTM9PT3VVdXfdzP+f949TeUz3MTM+9Z5jznXVW93RX1zlVdfbez36e7/P9alQqFVll2vdajzroUVUV308IU4IU2Ov1sCyLPXv2sGXLFj70oQ9RrVYJwxDf9ymXy9x4441MT0/zX//1X1QqFWkA2Ov1JAFJBE0Hg+/7qIpK3+7LNvIXvvCFfP3rX2d2dnag0ZGl0+lwww038NKXvhTf9weutwaWZTE+Pi51PACWlpakjkK5XKZSqUjhJkGUEpYUpwP2vYFPN52X0xnCFBGg1Wrx3e9+l5GREd7znvdgmqYk01er1UGqP+KKK65g48aNfPWrX6XVamGaJsVikU6nI2Uc4jimVCrR7XYl+b/bTcTJxBzhui4vfOELmZ6e5uabb5blKMMwZLv5Aw88wOc/v7O2wQAAIABJREFU/3ny+Txr1qzB933ZxaHrunS7fvazn41hGHieJ9t6HceRDQrdVoviyIgs0+m6TrvVorHUwHZtZufnEv0tYGx0hKxl0Vo6MbIRKU5eiIVWbOgBSdPI5/Pk83lGRkYS5/GBIrht21KH50RcnwgUhJBrJpORGnGGkWxmfD+k17MJw2Qjn/zN8b++lSDa7v3Ax/M9SUOJ4xhN0/B9n2KxKFWvhUCtpmlyU7VvEHbUQY8IBoQLrOjB73Q6fOhDH2JmZoZLL72Uhx56iE6nQ7fb5eGHH+byyy9ncXGRG264gT179siAqFgsJoHMUDB1MFgZi26vK63l/+7v/o5HHnmEt771rezcuZN6vc78/Dy2bXPddddx//33c+uttzI+Pobvh9x1113ccccdLC0tMTk5SRAEjIyMyNfheR6qqtJut2VdFk6E79XJh/1lfY53pibNBK0uBO9AyNbv2rWLCy+8UHJixAan1WrRarVk1+Lv/u7vsmPHDqIokuO4UCjIwCaOY3w/cX8XCubC+LdQKMjJ+vd///fpdDp85CMfoVqt8uIXvxhVVXn/+9+ftORms5TLZXl+27bZuHGjzFCVSokDtJhfhIBZt9sll8sxMjJCvlBIzFddl2arRbfb5fzzz2d0dJTJyUk2btzIpg0bWDc9zRM7dsj3RnCOUpzeEF5aIhsqRAJF5UDwWeM4JpPJyAyEWJSPBitlWkRlRfDlYG9yIjHFjojjRJokn8+iaYfWVXyiEBPjui5xHGMaJoV8gWw2u8wAudVqoWkauVwO0zTl+18qlZ4S8ByTTM9wqSce+HpYlsXtt9/ON77xDT796U/z3e9+V5r+qarKxMQE3//+9/mHf/gH7r77br72ta/JSWoYh1Le8nyPQr6AgkKtXqNWq7F+/Xo++MEPMjkxCSCf99Of/jTPeMYzuOuuu3jiiR0YhsZrXvMa3vzmN5PP55mdnaXZbEpPFKHxAlCpVGQbnNhBDnv3nC5IMzynF6IokqVmwzBkYNNoNBLzwYE0vGEYlMtl2u0269ev59e//vWQKW2SKYrjmJGREUZHRymVSnLyeslLXoJpmvLxe/bskc7QlmXx5JNPcv3111MsFpmbmyOTyfBXf/VXbNq0iQsvvJB+vy8VWCcmJti6dSsbNmyQKq21Wo1KpUK5XGZkZIRcLse5556bmAfnsiwsLJArFNAyGZ7znOdI3RNVVQkH5XDNNOk1m4yPjxP6oQzKUpzeEGuBruv4vk+73ZbrVjabxfM8mZUQkidiE1AqlY779e3evZt2uy2dBGAvJSWTyaDryT0cRckRBIkzehiGeN7xL7+tBDG3AARhQBiFMhsMSSmrXC7LKpEgkbdarafYNB2z8lYikOTJwEdMGF/4whc4++yzufbaa+WHns1m0XVd+o+84Q1v4Mwzz+Sb3/ymtFcQ0vAiKl4JYhHu233Gq+OsX7+eWq3GZz/7WfwgKXdls1lqtRqmaXLvvffywx/+kE2bNjIzs4t+vy8n8qmpKarVKvl8XgY0wxGyUEgWUebRCg+mSHGyI9kNhrJDS/gHjY6OSqdnkaVpNpuUSiVs2+b8888nCAI5XiDhPfi+T7PZZGlpSWZ8fvzjHxPHMbZt02g0JO/AdV0ZsNx000386le/wvM85ubmsCyLer3Offfdx3vf+14WFhYolUrLlM/FdY+PjzM/P0+r1aLdbtPv93niiSdot9s4jsP4xASu59Lvdnjov39BJpflwQcfxPN9oihmz55ER6reWCKbSV6/oemHtClL8fSGyOKoqipLRyLYFgbK4v7XdV2qBIv783hjenqaTCazLNjSNE2um0mwE6OqoKoMym46pqnL0tdqwvd9DN3ANBIulDDhFmuwKC/GcUw+n8f3fTqdDuVyWYo/7osjCnpE9mM4ZSRIgcIobc+ePdJvI3HODiRJMQxDGYz8wR/8AQ899JAMcoSQWKvVkkHSvr5V4v+6nuwuNT1J3y3UFnjHO97BxMQEf/u3f0sul0PXdaampvjGN75Br9ejWq0OIu6A6elpmWYU7eyzs7Pk83nWrl0riYuFQfrbMAyKxeKyaxHBj/h+enp6GUlTBHAnS7rwQOh2u8uUQcWgHL7+/b0OsUNYrcP3AzzPJwwjFAVs20FRYPfuWcIwwrYdut1ELr3X6xPHSVms0VhCUY7/53OqZ8ZM05TcgyiKmJiY4Ic//CG+78tASPxO2LP4vs+tt97Kli1bGBkZkUFIqZTYggxLWUCiWiuyxCIlLZyoBbm50+nIsZvL5bBtm1arxate9Sq+/e1vy1J0u92WgdUwUVTMBaZpEoYhpmlKcVHHdeTOd82aNSy1WmzatInA9wmjUMrxJ2NfxTB0NE0lX8gdU9JmisPH8OcsKAgi4BBzuu/72LYtN9UiWBUbW6F+LMw/DweKosiNvLi3xSZffC8gvh9ez04EhKyMYez1KBRrsSBg+34SgCU2EUlwFATHPyhbCaZpEg/+ifdL8H3FPAF7S81ijYYDU1CO+l0X6ofDA79araJpGvV6XRIFhd6H6KoQ5aFeL5HLbjabOI6DZVmDzogS9Xp9BQfygEajQbu9KMla3W6XX/ziF7z97W8fpL1iSWIuFApcdNFFzM3NSa6B0PyIB9YOa9euZfv27SwtLRHvxyV9f67pi4uLMnX54IMPJmnxQ+w+W234vk8URTKwA6TOgbixDnaIHcJqHebAgFS813Ecs7i4xLp1awddhdZgQoJ8Pie1lcbGRmi1Osf9/T3Zg92VoOu6DFqy2SzXX389S0tLfOELX5AGuELlWFim3HnnnQRBwCWXXHLU59+4cSNvf/vbmZiYwLZtqd8TRRH1ep1NmzZJjg4kE12xWJQ8hv0FteLejRVQ9aQrKzu49tnZWYr5PK1Oe+8keyDpESFY9TTG/jY9w8ehegger6NSqUh+mPi8hG6cZVlSK0esN5ZloaoqTz75JMIqaGRkhH6/Lzkhgr/W6Rz/+eF4Q2STxOsWa5ZlWYPSUBFVVdm1axdRxCBbZdDp9J62OlTHpLwFyeDIZrOEYYjrunKHJhZTQTQSJCPhaSWcyEVqULSxCyO2lRZdK2PJEluhkIgR5rI5PvnJTzIzM0Mch8zMzDA+Po6iKNx33328+93vlux5IQcudgadTofJyUnm5+dl2e7gi766LNpcs2ZNIvxUqZwSNX/RUQBJ14FIgYqfHTzoDAnDeFUPXTdRFY2xsTHm5hbI57MUCgWefHKGTMZgaalFqVSg1+vLzI7vJ9ctdgQpDgyR0XQcB8/z+J3f+R0uuugiPvjBD3LxxRcTx7HkCjiOw6te9Sre9KY3cfbZZ/P+97//qM6tKAoXXngh3/ve9/jt3/5tVFWlUCgwNzdHEATs3LmT2267jQ0bNshSs9i5iozziudAIYgjuekRma0wDA/eUvw0D3YEVpr/VvsQnJlms8nk5CSZTEauM7VajUKhIG0bisWiDAKq1SqWZcnMTrfblTQGQcZ/uswPvu/L90kkKCDJbHU6PXbv3s1ll13GN7/5TRRFodvtUyzmqdUWV/nKjw+OuminqipxHOM4jgx6wjDkmc98Jvfddx/tdptSqTRIofky01MsFnEchwcffJCpqSlZ7lpYWAD2RqYHr3tGOG4PTUuCnyiOyGVzNFtNKuWkpdXzPKrVKvfffz9r1qzhD//wD/ne976H7/vMzc09pZQmWvvEBLhS3VWkyvv9PqZp4jiOND9bWFhgfHz8aN/i4woRkHqeJ0sLgFxEVpYNWN20vmVZFAoF6vU6mzdvlveM6zhMrVnD7OyupzxeVcF1fTIZ47RZvI4Uw/e/aZrMzs5yzz33cNZZZ/HAAw9gGAb5fJ52u83IyAitVotcLscXv/jFw+a87a9EdNNNN/GKV7yCe+65B8uyKBaLsiQ9Pj6Obdt84AMfYGJiQpKoRUZoZGTkoJk2RVEIB6aESaZAYbQ6xuJAssLMZAjiva9fiY+Fm9+phZM9Uyn4HePj4/i+T7VapV6vL+sAFJ6I9XpdbqzFZy424RMTE/I5oyjCdV35u4PhZC9rapomKxYiGybeM8uyUFQd3x+h1+th27aUi/G8gPHxMU7yj/+IcNRjWAiFqaoqI+pSqcRrXvMa5ufn+cpXviJT0oVCgVKpJDs+/vmf/5nHHnuMP/qjP6JWq9FsNpmYmKBarcobTtQ/D3Tkc0k7akzywU6vm+aqq65i566dACwuLqLrOuvWrUPTNNauXUupVGJxcZHx8XGpxTMsSAbJTuBQzi94AaZpSv6RCJaGB9LJirm5OUzTpNPpoCiJGKOofx+KzUYcr+4BsDA/L8unxWJRZtjm9uxBVTRGRsZYu3YtmmZQq9Xk6xaaFCkOjE6nI+9127ZZu3Ytruvyq1/9is9//vMYhrFMD0NIRUxOTh6QSHgoEDv5c845h61bt/Kxj31MXk+73WZiYoIzzjiDxcVFLr30UllqabfbjI2NoWkai4uLB+RricXKtm0s08IcaJd0Oh1MXWfnzp1EB9jwnE5moytlWlYbQtqkVqvJ7qlsNivlT/L5PI7jyMyNoiiMjY3xjGc8gx07dqBpGo1GA9d16ff7UsMtl8vRap36OkxCEyibzZLP5+VnJqoY7XaXRqNBs9kcGPAa5PPZQabz5KdnHAmU+AhC+eE/cV0Xy7Ik6VUQGtvtNn/2Z3/G7bffzkUXXcQdd9wh67CqqnLVVVfxk5/8hGc+85ncfffdUowsk8mwtLSEYRjLmO/7R4SiRmiqQhAG6JrOO975Z9x222384R9elYiW5ZKMUq9n87Of/YxXvepVbNq0iQceeJBer8dVV70ex3H4zne+Q6lUWtYxJsScDgYR7AnPMLFDECTofbkEJx8iduzYwcaNG6WQ3Jo1a6TC9r5tf0/F6jL89cEuLgxDCoUCi/U6hmkyNTXFzpkZALQBb0MQaBfrddasXctjjz1GLrv38z4en4+QdAiCQJaCFUWRu82THcN8vCiKpJ6VGMfdblf6Yc3NzTE1NUW322VkZOQpbd3i9R7ode8boMRx4sFVLBbZvXs3U1NTMvMourUEj0+Ux0W5XNd1CoWC5Hrte844jhP3dAXa3TZOr8/EWJU4CFms1Zlct544igiVmAiIFRUVBY2BY7Wwk36qedwxhaIocl4VBNkTiZUEWFc7EyTIyJs3b6bZbNJsNomiSFIUcrkc/X5fugQMi9BOTEywtLREtVrlscceQx+aJ8S9fPLjEFwLwlCKdCpKoha9sLBAoVBAN7K0Wi1e9rKXcf3113PNNdfQ6XSwLGvAhzz4c6tHee9HR5lqV49g8B110CMmlSAIpH2EWPh37NjBS1/6UhqNhuTKRFFErVYjk8lQqVS4//77WbduHa1Wi7GxMWAvOVqQaQ+MCAhxPZuMmaHZavLkkzO88Y1v5PHHtyWltiAmiuCMM87gySefZO3atdxxxx1ceOGFeF7AW9/6R8zMzPBP//RPjI2NSSKbMBhdCaJkJwjYYmEDJC9J4GRc5J54YhubNm2SAwOgXq9TqVQkN+vgWN2Ev5XN4zoO2VwO3/cZHx9nz+ysDIYmJyfZMRCUMwyDrVu3snHjeiBRITX0py7KxxKnetAzzG0Rr0V0aYlUuOMk3U9jY2N0u4lQqNDKGOZFHErQM/wVkvlFvG/C2kZY1YgOsm63K8etaAt2HEeWL/Z3XhH0OIFLxshIO9zI81F1g16ni+N5lMdGTuugZyWsdtATx7FUBRfc0CAIyOVyMmgeGxsbymy0yefzFItF7rnnHjZt2kS73ZaqviJwrlarMqA/ubFy0CMahMT7sbi4yKtf/WoefvhhUAwMw6DX7aIObRbOPvtsvvWtbzE5efBqxakY9Bz1Nn2YUCbqpyK6npqa4pe//CWf/exn+dSnPsX8/DwAY2NjfOADH+C6666TWSFh+9BoNGQLq23bKyy6MX7gkzGzhFFIpTzKc84f5V//9d/40pe+xIc/fBNWJpHKf/LJJ7nooou48847JZ8ojmOWlpawbZupqSk5uQvyJqw8qEW9WGR7RCugeB9We1JYCRs2bJB6Kr7vMzIyQqlUWta1c2CoxHHIagY+cRxjDSQDoihibm4ORVUplUps3boVTdPIZDKDDg6FXs+m17MH6qMaKann4IhjRQYYQpzQdV1KpdKy0nYURVLQTxCfD4UTsT+IhR5gcnKS7du3k8/nEfpelUpFKtz2+30KhYLkFAqXdsHNW/Fcg8N2bELPxzKSUm+pVCFfKklOjyKCnNMMK3Wgrvb8FgSB/KyFMvf4+DiLi4uyo9B1Xfbs2SPvR8/zZDZQURRJSRAWSEIn6lA2vasPMfce6HMa9i+P0TSDUqk0aO8PUPUYz3cwMqIDO6bba5PNZSgUj2z8nuw4okzPMGKg1W5RLiUdHL1+LylNGebg9wd/+iOJ1JYj4qkf+PJFWET5hmHQaDTIZrNks1lc11/mf3IkO++V3r5TYTd/KkPXdSqVCktLSzz++OMyayVS2ScLjlumZ9/bT9n/j8UYOfgZnxq8OnZAxtKJY7DtHqOjo7iuzY4dO5iYmCCbPbL3WJSyREZVpNRF9kaImYrysRhntm2TzSZeeoKsKjI6YkcrjB7L5TJBENDpdCSfQ6T5hQCpaSULm+DpDPN1YmXQqDF03cva1Zf94PjgZM/0rDaWlpZkE4pQCDcMg/vvv59Nmzat9uUdAsTadYCN436D7eH1Tt3n58PPp+59DgFl+WODIOLRRx/lyiuv5BOf+AS/93u/J725fN9H0xJ6x75z1Yla1566vh54rT/UazrqLXrfTnZa3V6XMArJ5/KYhkmr3SIIT5SMtbrPsRdBEDA3NyfJlsL1eW5uTvqMpDh10e/3qdfrzM7OLpvkhGTCauO474RX0IrZ35bgwI8YeuTgeU1TZ/euObrdLpOTk5IPsXHjeqL46Me3aZrYti3LC7lcDsMwqNfrUopiampKSikYhkGz2aRQKMgyuCgtizJiPp9n06ZNMrNcKpXo9/sycBAlkGw2ixI/NdARh8B+q1jHuayV4tAwMjKCZSWyJY1GgyeffJInn3yS6elpqd10SmJ4XO93fEdPfdyyPz7AqN/nsbquks1lqNXniQnJZjMIGl7CZ115BjnVcNRBTy6bQ1MT2W1N1ej1e9iOzXnnnYeurb6Mta7rvPCFL2RsbIxWq8XS0pK0nDgdvbOebmi327RaLSYnJ+l0OrLsAakh5LGYqlQV1q1LCJ0iW9XpdKjVa+RzxyaTJjyKhOCg67o85znPkZ0norlBqO1WKpVBp0liESPU3hMvIV124ExOTkqpjFKpJDO+QqZBBEonc3dSioNDBMMi8yeaFeI4PgX4OMcbB5sBIiBOGoAGUi2i29J27JO4c+3ACY7DeYajwlIzkfBWVZW+3Sefy1Mul9m+fTuef3LstGu1mkx3G4axzAvlaJFOmquLarUqu7dEu7qu67JT4XTEQfZ5hw3XDXGcgAsuuIDt27cDyFbgYwFFUeh0OlLctFqtSgkFSMbvfffdx8TEhORv+L4vO8pEyUp4fw1rsNi2jWmacjJvt9vSjysIglNCMT3FwSG6CgVPU5hCG4Zxamd6jhf2mRIVRZHyLfPz83R7XbJWVgqOPh1xTDg9w7ydWq3Gi170Ip7Y/gSO66xIBjs2nJ6DXF8cs379enbu3CnJjpDo94yNjREP5bFP10Xy6YBWqyUJrfl8Xi6Iq62Kfdy7t8Ttr+z9ur+gR92X0yO5AvtyCp7KA5iZmeXsZ5yF4yTyBZ1OCyubdMuoyl5O3OFAcHqGJR/m5uYYGxtjamqKRqOBpmlSCqNWqw34RK60TRm2H2g2m1Sr1QEPQZMZv0wmg+u6tNttqtWqDHqazaa0MDgYVntOSDk9K8O2bbrdrjScFcT6IyXSn1iI8tE+4+9Q/yYePF4Z/rkY3INsyFM4PXsfF4Qhuqaz2FhkbDTpnu71e2hqkiUXnFdFWX7frR6n58A4YZyemEQCXCEZnNPT09x7773J706CziVFUdi9ew+Kokil1iiKZHt8ilMbIr2dz+cTscqBDkcYhidxivYYYphbohy8F+1IpqkwhA0b1i7zISoWi7RarWOWKclkMgRBwNTUFK7rynOJrOz8QHxSmDQWCgVpNyEye2NjY8zPz0ttICGh0el0yGQyrF+/ntnZWak1JEpkaab21IbjOFJwUFhQnDo4Er7MyiWrw4GqqrQ7bcZGx2gsNfB8j3wuj2VZJ4QesJK32/HAUQc9MzMzlEolur0ujuMwOTnJ9NppgjA4KVr+wjDknHPOljtFkdoGDu6tk+KUgNBzGt4NB0GAYRiMjIys9uWtOkTl+0iXb1VN3OwTgc/Em63X61Edqx4Tzp7IyARBIDVVLMuiXC5LWYnJyUniOGZmZkaWLUTZSpgG9/t9JicnZSZXjG3RtVWv15menkZVVSmceDSK0SlODojFOYoi6Zc4LJtyauBICtKDkb1fQr0Ifg5Nw0dkD8V76biJfMmJWR+jfY6VoOxzHD6OurzleK5M4Y+Pj1Ov12Vd9VBSsce7vAVJis51XVqtFpVKRarJJiWGvdeY7uxOPQhhMtjrriyyPb7vU6lUVvX6jnt5a6ildXgg71u0UvYdJ7Ll+uDlrVarR7mcl+dIfIlsMlay0OjakQUOw7s5ITioquoy7zeh/SNKVsJXTXRfeZ4n29tFK7qwgBFmkp7nsWXLFnbv3i3b40V24GTYlK2EtLx1cLRaLcrlslxvhDzBvkKxJyf2LUfBygTdA7WrAwTsDXbEVmfwHiyTWNh73mhICiKOYwr5Ap7v4Xsh+Xx+SNH8+JS34nhfq5eV8jD7nvfwHQ/2e4bhCUl0OIlWVUAK8AFkzExSOzczbN26FdNIJh1d03Ec55Au4nhCxHRRFMkavuB5pKnsUx/DOkuqqkqCbT6fX/WAB05AIL2fpw9Jys4xMVEcJV8HiyZxTOh6fON/fZVcJoOVyZCxMmiahqJo5HIFstk8pdIorVZv0AkzeN4wxPd9qcgszIaPJBUt+FaqqkphUxGIlEolfN+X4pjJtSUvVCxkuq6TzWaXNSbk83l0XZemkkJd9uGHH0ZVVWkVs2/AI3a0wn9JvFaRaTqeqfYURwdBuBXBoFAAP1EBjxhXnufJAF1A3DPChHv451J9nAg/cBEjNnnOQN77ooIsSNmO49FqJeXfJMsZDr7fK8TpB3uvAaDfT9Zh2977+DAK8HyPdruNqqh7xzKxVLYW5WMxDkS3o4BY34czavsz6B6OFyAZb71eT3ZTOu7eMrNt93Bde5nTQxiGeF6A43goCriuJ6c9wfkT13UoY3XF8taw23av18NxHDlBOY6D4zpkrSyLjUUmJiYIo1AGSlnr8FyWTzTSiSzF8caJusfEWQ6W91SGHzhALpfD95PJdXQ0UToWhPCxsTG2b9+O4/jE8V6RT03TyJiZY8LpURSFXq+H67qMj49L0nEURZJTsL+NyYHe132DTFEy27NnD46TNFYIcjMgW9pFFkUow7fb7bT8lWJFCCkF0zSlxlSv15OdhLDXtFoER8OyGnIzQoTrOkRxIDfmIrPZ6fSkv52qqpTLZRYWFgZjJAn2DMPADzyiOMDQDfzAT7TzwpBcziKKIJszMAyNbrdLEASYhk6pVKLZaqKqKsVCUY5xkRUV4yCOY3Q9SWQIQVAxPoa5P8PjT2RjTdMkCAIZwMRxPDA/3StOKrrwhgVJhfO767rLNj7J+wZBcGRuACv+hed57Nmzh0wmI8miImqzLAtFUdi1exflcjmZEFVNRtknQ8t6ihRPZ6ygTbhfKHHiH6XECSev3V4ijkOeeOIJGo0GTzzxBDfeeCOZTIYf//jHdLtdoig5iyjVie+PBcIwpFKpUKvVmJhIvH6KxeIhczJWug5FURgdHZVt7o1GA8/zZKYom83KRoelpSXp45QixUooFouSiN9oNGR5vVKpoGma1J+KoogwDDFNU2YnHcdBUxUUde8IVhVVBki2bWMYmnR8NwwD27Zl52GSjfFlFsjQDVRFldo7hXyBIPAIgohOpyezRoaZrNGe70l/RdM0CcJAZm8ymaSCUyqVZDZWGLcahoHv+7KTcjjo2ddgWGxqhPm26KrtdDqyVO15HooaYzs9+R6JDs1SqSTpMq7rQgxWxkRVj3z+WTHo+epXv8p5550nTQTz+bzUu1EUhXPOOSeprWs6CgqNpUaSXo6jU6CmmiLF6YGn2CcMUCgWsSxLupkrikKhkOPaa69l8+bNPProowO+hCJLiWJiPBZyAI7jMDo6KsnnCwsLyWXGMZVK5SlZnkOVwx9+fLvdlp1chmGwceNG2b0VRZHMYBeLRSqVCt1ul0wmk+q8pFgRpmnSarVkYB3HSTezCApM05QZG5HpELAsEz/w0TSFMPbRdZW+3aPbaxNFiWJ4GMZomkKxWJQim5VKZVBxgUzGoFAoJIFVHOEHPkHooRDT6XYGfpAO5UpS9m82m5JDl2Q3VQzdoNPp4Ps+5VIZ207KS57nEccxrusuM84Wvnr7KxEPfy8yXPl8XgZOwvdMCEm2O02sTJI8yefyMrgpFArMzs7Sbrfp9/uYpjGQIgHPi+j3PXTtOIkT5vN5lpaWyOfzklwoUlGQ7BSf9axnsW37NgBGR0blbjDtjkqR4sTgSMXid+3cSaPRIJfLsbi4ONhlwec//3m2bt3KmjVrJE9q33r9sShv6bouu+yEpQQkE+u2bdsOGvAcCMOPN01TqjGPjY2Ry+WkyfCePXuIokh2ggm+T6FQkHygFClWQi6XW0b/qFQq/OxnP+MFL3gBMzMz1Go1oijCsiyZ/RHcnyiK+OIXv8jo6CjZbIHR0VGmp6cH5R+Fl7/8Mmq1GqqqSikOSKxVarWa5Pc4bsInMnQjMU/t9/jkJ/8SRdHYsGED3/nOdyXRX9d0fN8lY2ZQFIVXXvFKyuUxXve619G9foBlAAAeoUlEQVRqJwGc4MYpSmImLgI4x3FkwNTtdiUXaPj1iNKx2FDccMMNqKrK9PQ069atwzAMPvzhDwOCixXjOA5X/M4VXHTxhTRbDaIo4L777uPss8/mzDO3oGsZDCODZWUpFArkCwUymSMTSF0x6Gk0Gpx11ln88Ic/pF6vs7CwIJ2M4zjmxhtvpFKp8O1vfxuAMApl26AwHU2RIsXJiQ0bNnPWWWehKBrPeMYz2LJlC4VCgU9/+tNks1kuueQSisXEnFfw+URgciw2NbVaDc/zKBQK0lJC7GpFSQqOPJWtaRq+78u0er/fZ2FhAdM0Wbt2rXSP3759u7TDELth4deXIsWBMLzgiyqIbds88sgjbNu2jfHxcSqVyrKGC5H98QOfjJmUutptn3IlRxBEtNtJAJPPZ/nBD37A5s2b2bp1K4qi0O12ieOYxx9/nGq1SrFYlN19gswseDPtdptcziKfz/PrX/8ayzKT7sYolI1JO3bs4MEHHySbNZienqZcKpPL5pY1ISXZIk+WooTXncj+DPPrBNk5iiK2b9/OhRdeyC233EImk6HVasms2N/8zd/w/Oc/n16vR7fXlZwd0zQpl8u0222WlhaZn68tyyiJYExV1ONX3hLpu9HRUSzLki62nudRr9f5+F98nFarJSWsNVWT9fATZziaIsXpiyPNtwgqQS6XwzQT644dO3Zg2zZvfOMbmZmZ4ZnPfCZBkBB+h32r/MA/JuWtM888k7GxMZrNpiQ8irZjwek5kslN/E2n05HeQt1uF8/zWLt2Ldu3b5evCZCLk6Io0sW9VCod9etL8fSG7/vkcjmpMyUyOd1ul/Xr11Ov12V3kfi56Eg0dIN2t025XGbz5jXce++9BL5HFLk4jkO9XufGG2+k2+2ydetWLMuSHanCUHVxcZF2u00hnzQftDttDC3J9ui6jmEYvOhFL+KOO+6QpWNIuEie73HnnXfyvOc9j/HxcRzHodtLSrpC8kG0/guj31KphG3bUt9HKGALKovQvwqCgAceeICHH36Yd73rXTSbTZkoaTQavPOd7+TnP/8FX/va1zBNE9Mw+Jd/+Q533303pmlSqVRwXZfzzjuPH/zgB4ShSxz5NJstdu7cRbvdxnGOrPx8SEGPMAEEZF3OMAyq1Sp/8qd/wsTEhEwJJzXKZHf1VPGy/bg5p0iR4qgxrLKjxsvVPqSL+LAcCBApSavr1kcfp9vt8uijj6FpCueffz5fvu2LZCwDw1Do9tooirIsw+M6PoZ+9Do3QRCwe/duYG/5TNT/BW/waFAs7u1IKRQKUpV948aNZDIZLMuiVquxefNm5ubmpJLz4RCpU5y+kNpbcbJ52L1zFx/4wAd4z3XX8eijj3L+s3+DT33qUyzW6okZasYaSEckreVJCTVm58496JoJKHh+oh+XsXK8853vxMpleeSRR4CITqfFy152MZdccgmqqjI+PkI2m2GhtsC73/0e3vve91JfbKLrJlEUk8lkefWrX8vWrVvpdDp0Oq0kW5OxiKKIn/3sZ1x99dXEcSw5b1HEIJAxOXPTWWiaQS5X4Lzznk293iCTyVIsFul2+zLbK8jMQm8rCAJ+9atfkc/n+fM//3PZkeV5HsVikY9//OOcffYW7rrrLiJiev0el738t3jFK17B9ieeIAxDSpUyc3NzZHM5ogg6vSTTXKrkyedNej13/x/KCthv0DNMHhRtclu2bCGXy1EsFtm4cSOGkRCLvnTrrXQ6Hd72trfJuqPneZiGPtAf2Fdx8XAVGA/lJRz4UBQN3w/RNIM4VgiCiKWlFqAShmnLeorjC5H6FVkR0Y56rDqfhMPOsq9KIvqpoqApKgoKChq+6+PaLoqmo2cs3CBgdvcchUIJw8iwYcMGHnroIbZvf5znPe95iWaG55PJGGSzSYdK0j5qYJrWMt+6A0Gk/oUFhJgkZ2dnOfPMM+X7I3R3hjs+dF1fUZ5+JQn7KIpkd43neYMW/WRjtrCwgKZpnHvuuezYsQPLsshms7IrZV9Lg5Uk84/kkO13BzgMTYcohihGUzXiMCIOo4EG3bG/nvQ4tPtMdGSpKIPPJIQYdFVFRcFQNRQg9H3sXp+cZUEMs7t2oakavuMkm5EopLG4yOTEOO12jyjW0Q0Lzwc/hP/zz98ik83yzGedi5HRMTM62VyGMPDwXBu738E0NfLZLHOzewANXcvgugqKYtHpOlx62cvJZrPcfvvtjIyUyWYy+L5HvVbjnv/4ES9/xStotjromkkUAnHMrx7+H3JWntpcjek16yBWWGq0WDe9kUe3biMGrGwO00w2PqIULILATCbDOeecg+u63HrrrbRaLSkVsbi4iGVZPPzww3z7zjtxPA8rl8UPQ2zHYaQ6BqqCH4V4vk+2kCeIYjTTQDchiMDxInTTQNNUKeAJe2OXg2HFTI8wcRMGf5DU4cMwpN/v89a3vY2dO3cmbGzDpFKuoKoqMztnMPRh7459szzHKug5OOr1OmeeeaZUZNY0TSp2rrYZZYoUxwLKPl8BuWhGQYjvJdIRhmWRsSx6vR49u4+ZsaSQn+jUWLt2Le973/v49a9/zV//9V8PAp6s1LIRashwaGUn0apaLBZlacxxHNauXct//Md/MDs7i6ZpsmsqjmMKhYLk4Bz1e6MoNBoNdF2XRMxyucyOHTvYsmUL7Xabu+++WxK5+/2+zDClLuwpVoLT7ye6x7pO6HlMrl3LJ/7iL/jLv/xLNq5bzwMPPMAnP/lJsoUCoeex/owzIIowLAs1TkQHrUyWXbtqvOp3fx9NNdH1PKVKlYxu8bGPf4I3v/nNXPrySwnikG63g2kaA5IxZC0Tp5dkb/L5Ao7tkc0WMU2TOFYxBrza1772tTz00M/wXBeUGF1R+f73v89znvMcquMTWJZFu9vBymTo9Xq8593vJvA9vvSl29i1ayeB5/PAA/9JPl/kda99Pc22SxBBGCbE5VKpxNLSEr1ej3q9jqZpvPKVr6RQKHDrrbdyxhlnoGka55xzDl/4wheS+URJtPwymQzdfj/p8jIG1SElIUh37T5r164lX0o6K/PFUTKmRalSYa62cOAP5iBYcdUXrsTz8/My/Xv//fdTqVS44IILuOWWW2g2m3iDiTWMQgzdYP369Sw1l47ooo4lqtUq27ZtwzAMKpVKUnbTdbnLS5Hi6Qx10DbK0K51OOMiHMlFG+vIyAjXXnstZ511Fp/61KfYsWMHURTR7XaxbRtN05IavGlKEdKDQai5FotFab2haRqNRoOpqSlJHp6ZmcG2bUZGRoiiiFardUyI0kEQSHf2paUlqXmyceNGWq0WxWKR888/H8dxsCyLXC4ny2tp92mKlWBZVrKpGGRv4yCgMjYm769NmzYR+j4InZkwpD8gEScaN3uFMqWacxgSRhEYOp7v84uH/1tqTJVKJUzTRFEUFhcXWWo0iONYZkkdx6HX79NstimVSnLM/dFb3sKDDz44SFgkZOPbb789KW0NdCzy+TzKoFqzc+dObvroTbz61a8mcENUDdasWcOXv3wrnW5LZm51XZWbg5GREcbGxqhWq4M2c5O5uTkuv/xyHMdB13VmZ2f50Ic+hGmaXHbZZdQX65i6ie8HaAMXB8dx8MOk+SAOAiqVRDTVdxxspw9xSLFYPOJGgxWDnoWFBXK5HI1Gg3K5jKZpbNy4kW984xs89NBDXH755UltsToOJDoArufiui4jldU3fOx2u4yPj6OqqnRcBhgdHV1mrZEixYnEcOr8eEMdBD2B60IcS42NOI6lB50QRBNu5zfeeCNRFPGRj3yEmZkZSfTt9XosLi4CLNPuOBBEp0oURdRqNanHo+s6rVZL/l4osf7nf/4n7Xabbrd7THS+RIlMaH8MS+w7jsOOHTtkVkl4Dblu4ic43HFzsuBE3jcpDgGqKoMVdSCi12216HQ6qKrK4uIiqqryla98hUqlkgjulUvoqsJHP/pRKdNw5pkb+MEPfkgYeXihQ7vdxra7fP3rX+cnP/kJ1113XcJz0w0WFxfpdDqsWbOGkWoVTUvGkx8GqKoug3fbtmWG9vzzz0fVNe677z6IVWZmZpiZmeGiiy6i1+8xNjaWSM34Ps1mk507d/LxT9zE5OQ4Vs6ikK+wZcsWXv3qV7OwsDAoPyfhg0geJORiR5K7xTxzyy23SNX1n//854P2/Cz/8aN7uf7666k36jLTrGma9MfrdW3ypQKPPvoonucQRD6B72APNklnnnnmkX1kKz1gzZo1BINoa+fOnSwsLDA+Ps4ll1zC29/+dn70ox9x8803y04tIcWtqipRvPrp4TiOpSy4ZVk0m02ZvRL6IylSPF0RhSGe69LtdpNy0cC4U0yIlmUtK/PGcaIE+7rXvY53vetdfOtb3+Lee++lVqtJoTGhX3MoRF9BavQ8j2q1KoOrUqnEyMgIpmnKYMg0TTZs2MDc3BxnnHHGMREHFB5aQtm12WxKKwrHcdiwYQNhGEopfMFhTLPAKQ4FURCQG6wjnm2jZzIUyuVlooSKrkuCfBiGZAY8GF3XWVpawnVdZmZmBhkcUBTIWKBrcOWVr+Sqq17Pl7/8ZXzfp9lqMjU1NbCygFazzVxtQa5nQkvPtHT6ro2eMbA9F8PQuPzyV/L1r/9vNF3n/3zrmzz3ggtYP71e+tQJw+Zut4vnJyKClmVh6jqOa9Nut5icnMRzXbLZDIoKrutLb61SqYRlWcvKwqKJQCQbzj33XBYXF9m2bRtXv+Eqvva1/42mJVpd/X4f1/WxrByGnpEyFrbdI4oiGktNuj0HTVNAiY+YnrLiXzWbTZk6y2azTExM0O12qdfr3HLLLWzcuJE77riDZrPJY48/Jvv09/XKWC0Ui0UajQaVSsI1Ei7ruq4zNze32peX4jTFiRobnudhDiZizTRpDnaJf/KOd2DbNtlcDl1P2tWFKaeYoG644QaeeOIJrrnmGhRFYc+ePTI4gUMzdRTGoYZhyBbXpaUlWTJrtVqMj4/LrtAoipiampKblKOFIEi3Wi36/T7lcpkgCJifn6dUKskyASCFCgWn52TMBJ8Mc2qKvYgAVDUx8hXinWEoW9PFxvrqq6+m2WzSaDRot9v0uj0++tGPUqlUKJUqZLO5QQkLhqlk0YA4XSqVpEbNunXrqdcbNBpNypUKGzZs4tFHt/Lwf/8KVdfo9/s0W12mpqbI5/MDMcSQq6++mrt/8AOWGkt8+//9Dq997R8AeyUaRBl6ZGSEMzaewc0338zPf/5z+o6N77sEgcPWrVuJYo/169fT69lkMoZc88V6mslk+OlPf8rk5CRXX301pmnS6XRYWFiQqtTZbJazz9qCqiYBkambUvRYxA/ZbFYGiqqqMjpSoZC3iONkM5PRj5NOjzDf63a7FItFmSZet24druvytre9Ddu2ueqqq9i0aRPFQpF6vY5t2/t1XD3REJGmEBzr9/tyRzc5Obnal5cixXGFlc0S+D79TqLcWhkbozxQQLZtG+LESHB4rIouzPXr1zM2NgZAoZCoxeqDXavjOMs8dw4EITgGCb/HdV1GRkZQVVWKubXbbVkCEwGXKIEdLQRfolwuk81m5cQ8NjYmS0VCj0dYBYjrTjPBKVZCHMe4jkMUx2QHGVAvCDAyGcojI/x661YAcoUCtuuSLRSIANt1CYnp9/t0Oh02bNhAp9MhimIUBWzbo9d3uffeH/H/3Pa/uOCCC5KWdytHPp9nfr7GT37yExzbYdvj27j1y1/isce2DQjNeVlySyxkEr7ec5/7XLLZLH/3f99Cv2/zm7/5YpqtJoaWQdO0ZD5QFNatW8eWLVv42Mc+xu7du3H6duL51Wrz1re+hXy+TK/fpVjI8uCD/8UFF1xAsVjkWc96Frfffjuu6/Lc5z6Xl7zkJfzLv/wL11xzDcViURr6ttttHnnkET760Zt4/vOfz/zsHtqtNsVckZFSGV1RicOQXqeD0+9THR0lDkICLyAOkzJ9MZeR7vGHixWDntHRUcbGxmTd3/d96Xyay+V43/vex7nnnss999zDP/7jP9JsNRkdHaWQL+xHp+fEQ0y6QtRJdKsMO92mSPF0ReD76IZBbjAhR76PPwgExCYA9vJzHMfBtm1KpRLz8/NSgl5I6AuTQEGmXAlijGmaJlPwwtxTlNLELlYEUYITIAKWo4Fwiu50OiiKwsjIiNw9Ct0QsUgIvg881XIjRYr9wRiUsVRVJQwCwiDAHGRL5+bmuPjii/nIhz+MMiA62wMBQ13X0XSTcnkUx3H4n//5NRdffDGZTIZstsDIyAjj4+NcdtllmHmT17/+D1AUhfpinVe8/LcpFUu88Zo3Mz4+ybOf/Wzu+v/+jUsuuQTH9vDCgPHqCHNzc5LHqigKVibHb/zGc/ibz9zM5s1nMTIyQqlUISaWYzwMAjKWxU033cTc3ByXXnophVKBLVu2cNZZZ3HXv36fd7/73VQqFWZ27uJP//Tt3HbbbXQ6HX7605/yx3/8xzQaDQzD4Oabb6ZYLHLnnXdSKBSoVquoqsr69et52cteRjab5XOf+xxnbj5T8gsdx6Hb7WKaJoVCQdrDCDd5gGw2g+/Hg0zw4a/hKwY9b3jDG9izZw+Tk5PSj0aknQQB8e6778Z1Xa655hrK5XLixzH4p6zw73hj392oiDYFcTJFiuMJcY/V63Vgr96HMLuEvQusSP3W6/VlbeT7aoYcDjRNI46ipHsrilA1DcM0YaBDIzgAwzLwYmMwPj4uAxxBMhReO8PaGCudf6+5oSZfixh/lmU95blFhudYEIlFyl5IbggCt2maZLNZyWXQdX2ZLpA497Bm2f6Oo0Xg+xDHtJpNwmHTRt9PjjBISB4k/CxRLhSvLcXxxYHGnvj8A9/HMM0BH8WV4/2yyy5jcnKSfD7PPffcw8L8PPmBm4HQgIqjiH6/h+N4rFu3lu4gQEnGgoKmK6xZM8nnPvc53vjGN6LrOqOjo/zmb/4mn/nMZyRn6LLLXs5dd/0bnudJ54QohiDyCeMA13eIFDBNgyuvvBLTNLnyyivxveR+qtVrVKtVOp0Oi4uLxFHEueeey8zMDI7bRyGm1VrCcfp8+cu38ud//h6sjM4vf/lLxsbGeMlLXkK322Xz5s1cd9113HPPPcRxTLVaZWZmhje/+c2yQ1RwbF//+tfz2GOPDcjIqnR6N00L102yVEEQsGnTJnbu3ElMTK0+PzBDTSqKwm5DfB6HCiU+ypETHTDSSgbm3sBm/6RmhdXPBqVIcbyQiPlpsp1UVdVkwhvSvBLuzLqu02g0GB0dlX87vPAf1iI7GJZxJMbhAR/CwTQGD2sy2c9jxQJ9IHf01V64DzRpHurrPtrrV1DYMzvLmrVriURbM5AdCCMaus6uXbvIZrOUyuXhEyf8hyN0mk5xbBD6ScUgDEOsQbZ0qdFgZHSUmR07mJycZM+ePZyxaRPdTkeS5g3DwHZ6FIoW/X6PMFLIFyooKPSdEMdz0HSFQs4CQqI4pNfvoAQKlfIoxCq9bp98IcdCbY6JialErxKwHRfLyhCRdFRVSiUUoG87FLIWCtBptSmWC+yZn2NicgrXsclaWRTAc11Mc9CZOdiQub5PvbHI9PQ0nV6XXL5AFEcETuLALjZC2WyWf//3f+cFL3iBbAawbVvaU4jsrnBat90+O3fuZOPGjQO1dIc1U2sAiOKIhYUFJicnpZ1MLpuj3e5iGIlgajzgAKVBT4oUJxE8z5PCeKKMEwSBJPj2+33Z4SC4LZCUeY426OEQhvchCCsfEtKg5wgwUFW2bRvTNJNdvqYRDLrI1qxZw7Zt2ygUiwB02m0KhQKKUPg+gvR+imMHkSUVWVpI1MaHzUDb7cRfq9vtys5HgH6/S6u5SLFYJJcvoag6UTQYj4PbLybEdruYuoGhaWhoBEGEEicZyjBOgom5uQUmpyaIgE63RyZrYWgaQRQlRGASYn7eymJZJq1Bo4Buaiws1pkan0BBoTY/n7SbZyzZ3JAvlfA8F22QgXV9D0XX0FQDLU6yufV6nTe96U381m/9Ftdee63034KnVlsERKBk27YsrwvqiTA0VRRlwHWKKA+CfsdxlpmgHm7Qc9TbhNUuX6VIcTJDiHaKmrkoowy3RIvMTxiGzM3NycBntQMCOP7lndMdtVoNVdMS3yPTTDSVSO4bVdOo1WtJiWUQPBYKBUlSFUrbKVYP7hA/zvM8MpkMZ5xxBr7vs7i4SKPRkOR8Ma6XlpZwHIcwDJmcnKQwUCv3/ZA4ltVM/NBHQSGXyWFoGrbr0monLuWarmKYOvV6gyAImJicoF5vEEYxhUI+8bryfTRVJWMYdLtdRiplLMvE90MqlQrtbgdNTcRGe70erXaLUqmUXI9hUKxUyA9I/iK40zSNrJUEKI2lRHm5Vqtx3nnncfnll/OWt7xFBivCrqPX60kOXxzHOI5Dv9+X93E2m5UBYxiGdDqdvSKFvk8mk5EBT6/XO+rO8KPO9Bz4j/fN7KSZnhSnH4Z3d7ZtS3+nXq8nVYCbzSZjY2NSFE9khkQ6WGA1Mj0rnXOl60szPQeH2Bj2ez2p99JptymWSjQWFznjjDNodzp02u1Epl/TaDWbFAqFRD7AOnrT1xRHjiiKcBxHctREt5RQJPY8j2w2S7+fmHOWy2U5viGi004yLoZpEQ9yEEEMYZzYNClqiOe5ZEwdDYM4DPG9GF01ABUjo9JqdSiVEwNQM2vheMk8ks3liEgER7O6gQJ024noZ8Y00XSVWn2eXLGAZSSNCZqiEvg+ShSjmSa+4yRZaWXQCRoENJpL5EuJ1UVtdoELL7yQv//7v+eKK67AdV0ymQy7du1ienp62TgXAaIgVkOSzTYMQ86FkMyTw40NgGxnF5tFIXIqskWHMzemEUeKFMcRQmBL13U5ORYKBWZnZ1m/fr0kKwvuj67rMjXc6XSWpcOPCIcwGaQJm9VDODBxzeXz9AeB8OjYGIv1OmPVKt1eItBYLJWSYEh4mA0I2ClWF2LMikVX6EuJrI743bB5rch2hKFPcZBJgYTDEgaJ0aZmqOjqwLzTzCDywqqqYpoamqoRhRAGAysMPySTSzZTppVwhvwoxFA12v0+er4gNbYsy8SxXaJYZ7w6iRMkUhK5bA7XcQYNDRlCz8OwLAwABdkIkM/nieOYRx99lJf+Xxfzmc98hiuuuIJ6vU61WsX3fdatWwckmRnDMKTytICQjRHle9M0payMaDCwbTtxhN+ncxSQpa0jQcqCS5HiOKLb7crBXSqVqNfrLC4u8qxnPYtMJkOpVOLFL34xlmUxPj7O1NQU9XqdIAgoDngcKZ6+EK3zGdNkcnKSDRs2oGsaW7Ykwm3r161n186dAFJPSdwXXlreWnWI8ovgr+TzeamMrOs6vu/jOHv1ZPYGHlaiAxXHBL6P67oDjp+CldHRVBU/dImIUAfLtBd4kgScnDtRZdZUA8/z0FRFyi+4QeJd5fgehUIh6bTOZGR5y9CTbIvjOnhuIEtwsDx76fR6BK6LY/dYai7iuH2KhTxRFLB9+3ZarRY33XQT4+PjTExMoCgKX/va12RZS0hUiNcnNniKogyCIJVut08UQaVSkfe24PmUy2UymYzssux0WkCEZZkoypFlWU9geUv8TB36Ckoad6V4GkOkbYWlgnAQ7/V6cvfXbDapVqt0u13Z2eH7vuz0EDii8tZKOMosT1reOrrr991EMVt0Y3W7XSwrIZGKDqANGzfKdnZ14PXkOA6lcjklMq8yhKVRs9mUWnCCiyIWcFHqEpIMe4nPPqoSJxISqICKH0QouopCQmJWiHF9F01TMVUDYoU4VlBR8YMYw1CIYlBUaLe7FEoF/IHcRc6yiAHbcchZFq7rYWo6uq7SaXcplgqEUTgYoxFREMpsTDAw5iaKQU34OYoKvZ4NakwuW6Bv98lnCywtLRHHsfT8CoJAtu6L1yu+h71jKwiCQSAfo2kKYRjjOH055wnpiqWlJSqVCoqiEEWBHAOJxMTh8wuPOug5PDw16EmRIsWR43CHrxInHB7xNUWKFMcPw3pW+y76yVeRHBjyvxv6+5i9IplJYkM8bu/gjffJeByo6HmgFfdgCRMFZehUx379PmpO3BHU5k8wp0fd52uKFClOJESgkwY8KVKcDHjqWrhsaMYHWisHgdR+xvHhrK4rVoiWPf/TY/0+ta8+RYoUKVKkSJHiEJF2b6VIkSJFihQnIVaUjDhKTtdqa22txvnTTE+KFClSpEiR4rRAGvSkSJEiRYoUKU4LpEFPihQpUqRIkeK0QBr0pEiRIkWKFClOC6RBT4oUKVKkSHEcsK945zBxd7WFOU9XpEFPihQpUqRIkeK0QBr0pEiRIkWKFClOC6RBT4oUKVKkSJHitEAa9KRIkSJFihQpTgukQU+KFClSpEiR4rRAGvSkSJEiRYoUKU4LpEFPihQpUqRIkeK0QGo4miJFihQpUpyCUFldw9BTEf8/KtyfeZk0+1kAAAAASUVORK5CYII=) 生成的醇銨鹽有較強的親核性,如果分子內有鹵代烷或OMs等基團,可能會發生親核取代反應。這些保護基用來保護羥基的有 TES (三乙基矽基)、TBDMS (叔丁基二甲基矽基)、TBDPS (叔丁基二苯基矽基) 和 TIPS (三異丙基矽基) 醚等。二醇可用環狀 DTBS (di-tert-butylsilylene) 和 TIPDS (1,1,3,3-tetraisopropyldisiloxyany-lidene) 的衍生物形式保護。三烷基矽基保護羧酸和胺很少見, 因為它們對水解反應過於敏感。但是合成實踐中又發展了許多含矽原子的保護羧酸的試劑,如 TMSE (b - 三甲基矽基乙基), 它被 TBAF 除去的機理與前麵不同,是一個五價矽中間體分解成乙烯和三甲基氟化矽烷的過程,同時釋放出相應的羧酸銨鹽。 這種碎片化的去保護方式還可用於一些羥基的保護基上,如SEM[(2-trimethylsilyl)-ethoxymethyl]醚、TMSEC [2-(trimethylsilyl)ethyl carbonate] 酯等。類似的氨基保護基為 Teoc [2-(trimethylsilyl)ethyl carbamate]。
來源:現 代 有 機 合 成 化 學 |