In the veteran's affairs topical trentinoin chemoprevention trial, topical trentinoin was associated with an increase risk of all-cause mortality. (在退伍軍人醫院的一個預防試驗中,A酸使用與全因死亡率風險增加有關)。這個試驗被提前停止。 根據這一點,老年男性,有吸煙史用A酸需要謹慎。不過這個人群用A酸護膚的本來也不多。希望有更多這方麵的研究。
ref:
1. Topical Tretinoin Therapy and All-Cause Mortality
2. Topical Tretinoin, Lung Cancer, and Lung-Related Mortality