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Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum ...

https://www.hindawi.com/journals/mi/2017/4856095/
by PJ Tsai - ‎2017 - ‎Related articles
Oct 10, 2017 - 2Department of Food Science, Nutrition and Nutraceutical ... effects of methanolic flower extracts of Osmanthus fragrans (OF) and ..... The intracellular lipid content of mesangial cells was also evaluated by Oil Red O staining ...

Abstract

The excess influx of free fatty acids (FFAs) into nonadipose tissues, such as those of liver and kidney, induces lipotoxicity leading to hepatic steatosis and renal dysfunction. The aim of this study was to investigate the protective effects of methanolic flower extracts of Osmanthus fragrans (OF) and Chrysanthemum morifolium(CM) against FFA-induced lipotoxicity in hepatocytes (human HepG2 cells) and renal glomerular mesangial cells (mouse SV40-Mes13 cells). The results showed that OF and CM significantly suppressed FFA-induced intracellular triacylglycerol accumulation via partially inhibiting the gene expression of sterol regulatory element-binding protein-1c (SREBP-1c) and glycerol-3-phosphate acyltransferase (GPAT) in HepG2 cells. Both extracts inhibited reactive oxygen species (ROS) generation by FFA-stimulated HepG2 cells. OF and CM also suppressed the mRNA expression of interleukin- (IL-) 1β, IL-6, IL-8, tumor necrosis factor- (TNF-) α, and transforming growth factor- (TGF-) β by HepG2 cells treated with conditioned medium derived from lipopolysaccharide-treated THP-1 monocytes. Furthermore, OF and CM effectively inhibited oleate-induced cellular lipid accumulation, TGF-β secretion, and overexpression of fibronectin in mesangial cells. In conclusion, OF and CM possess hepatoprotective activity by inhibiting hepatic fat load and inflammation and renal protection by preventing FFA-induced mesangial extracellular matrix formation.

In conclusion, both flower extracts of O. fragrans and C. morifolium ameliorated FFA-induced lipid deposit and ROS and possessed anti-inflammatory activity in HepG2 cells. In addition, both extracts inhibited lipid accumulation, induction of TGF-β, and extracellular matrix accumulation in OA-overloaded mouse mesangial cells. These results demonstrate that both flower extracts of O. fragrans and C. morifolium may have a protective effect on nonalcoholic steatohepatitis and renal fibrosis.

 

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100% Natural&Pure Osmanthus fragrans /sweet osman Hydrolat pure dew with Free Shipping, reducing phlegm& relieving cough 

Abstract

With supercritical CO2 fluid extraction(SCFE), essential oil was extracted from three cultivars of Xianning osmanthus. The fresh osmanthus flower was processed with a petroleum ether digestion method to produce the extractum. The yields of essential oil and extractum were 0.19 % and 0.13 % (m/m) respectively. The essential oil and fragrance composition and content extracted were analyzed with gas chromatography-mass spectrometer (GC-MS). The result showed that essential oil contained 36.99%(area/total area) of ionone, ionol and 13.11% of linalool; ionone and ionol contained in extractum were as high as up to 33.33%, while linalool up to 21.92%. Whether essential oil or extractum contains only about 40% fat acid and other ester matters. None of environmental estrogen (phthalic ester) was found in fragrance ingredients. The result also showed that the quality of O. fragrans Albus group fragrance in Xianning is better than that produced in Hangzhou and Anhui districts.

© Wuhan University and Springer-Verlag Berlin Heidelberg 2011

 

Analysis of fragrance composition in three cultivars of Osmanthus ...

https://link.springer.com/article/10.1007/s11859-011-0761-8
by F Li - ‎2011 - ‎Cited by 4 - ‎Related articles

Aug 26, 2011 - The essential oil and fragrance composition and content extracted were ... Whether essential oil or extractum contains only about 40% fat acid and other ester matters. ... XianningOsmanthus fragrans supercrifieal CO2 fluid ...

 

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Botonical Name: Osmanthus fragrans Method of Extraction: Steam Distillation The fascinating Osmanthus Oil has originated from China. It is a yellow to brownish color liquid having sweet floral and apricot kind of fragrance. This oil is extremely effective in soothing and relaxing both mind and body. It is extracted from the flowers of Osmanthus by the solvent extraction method. Osmanthus plant is botanically known by the name of Osmanthus fragrans. It is a genus of around 30 species of flowering plants that belongs to the family Oleaceae. Osmanthus vary in sizes from shrubs to small trees, 2-12 m (7-39 ft) tall. The leaves of Osmanthus are simple, opposite and evergreen with an entire, serrated or coarsely toothed margin. The flowers of this plant are produced in summer, spring or autumn season, each flower is about 1 cm long, white, with a four-lobed tubular-based corolla. The fruit is small in size about (10-15 mm), hard-skinned dark blue to purple drupe containing a single seed. This absolute oil due to its sweet, pleasing and highly refreshing aroma used as a fixative or base note in the perfumery industry for the production of aromatic products such as exotic perfumes, scented candles, incense sticks, room fresheners, soaping baths and many other products. It is effective in treating oily skin. It contains several skin friendly agents which lead to healthy, soft and glowing skin. It is highly effective in removing harmful substances from the body such as uric acid, excessive bile as well as salts. It is also helpful in preventing the inflammation in the urinary bladder.

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